硼中子俘获治疗现状及发展方向

马佳; 柏预立; 韩光

doi:10.3971/j.issn.1000-8578.2026.25.0967

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硼中子俘获治疗现状及发展方向

特约来稿 | 更新时间：2026-11-05

- 硼中子俘获治疗现状及发展方向
- Current Status and Future Development of Boron Neutron Capture Therapy
- 肿瘤防治研究 2026年53卷第4期页码：243-250
- 作者机构：
- 作者简介：
  
  马佳，女，博士，主治医师，主要从事肺癌、食管癌等常见恶性肿瘤的诊疗，ORCID: 0000-0002-2383-7706
  柏预立，女，硕士，主要从事恶性肿瘤放射治疗的临床研究，ORCID: 0009-0006-0500-2023
  韩光，男，博士，主任医师，主要从事各种常见恶性肿瘤的放疗为基础的临床及机制研究，E-mail: hg7913@163.com，ORCID: 0000-0001-5500-3338
- 基金信息：
  
  湖北省肿瘤医院启航人才项目（2025HBCHQHRC011）
- DOI：10.3971/j.issn.1000-8578.2026.25.0967
  中图分类号： R81;R730.55
- 纸质出版：2026
- 稿件说明：
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马佳, 柏预立, 韩光. 硼中子俘获治疗现状及发展方向[J]. 肿瘤防治研究, 2026, 53(4): 243-250.

MA Jia, BAI Yuli, HAN Guang. Current Status and Future Development of Boron Neutron Capture Therapy[J]. 2026, 53(4): 243-250.
马佳, 柏预立, 韩光. 硼中子俘获治疗现状及发展方向[J]. 肿瘤防治研究, 2026, 53(4): 243-250. DOI： 10.3971/j.issn.1000-8578.2026.25.0967.

MA Jia, BAI Yuli, HAN Guang. Current Status and Future Development of Boron Neutron Capture Therapy[J]. 2026, 53(4): 243-250. DOI： 10.3971/j.issn.1000-8578.2026.25.0967.

摘要

硼中子俘获治疗（BNCT）作为一种精准肿瘤治疗技术，国际上以日本为代表已进入成熟临床阶段。中国起步虽晚，但凭借自主研发，在加速器中子源设备、硼药国产化及临床疗效验证等方面实现快速发展，部分指标达到国际先进水平。未来需聚焦第三代硼药研发、治疗规范、治疗成本的降低与可及性的提升，以构建具有竞争力的BNCT临床应用与技术创新体系。

Abstract

Boron neutron capture therapy (BNCT) is a precision radiotherapy technology for tumors. On the international stage

Japan stands out as a representative country where BNCT has progressed into a mature clinical phase. Although China started relatively late

it has achieved rapid advancements through independent research and development in accelerator and neutron source equipment

domestically produced boron drugs

and clinically validated therapeutic efficacy. In several key indicators

China has now reached internationally advanced levels. Looking ahead

efforts should be prioritized toward the development of third-generation boron-based drugs

the standardization of treatment protocols

and cost reduction to enhance treatment accessibility

ultimately aiming to build a competitive BNCT clinical application and technological innovation system.

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references

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