急性脑梗死患者血清circ_0003204和miR‑532‑3p水平变化及其与炎性因子水平的相关性

郝旭苗; 马海峰; 郝光

doi:10.14188/j.1671-8852.2025.0883

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急性脑梗死患者血清circ_0003204和miR‑532‑3p水平变化及其与炎性因子水平的相关性

临床医学研究 | 更新时间：2026-11-05

- 急性脑梗死患者血清circ_0003204和miR‑532‑3p水平变化及其与炎性因子水平的相关性
- Changes in serum circ_0003204 and miR‑532‑3p levels in acute cerebral infarction patients and their correlation with inflammatory factor levels
- 武汉大学学报（医学版） 2026年47卷第10期页码：1359-1365
- 作者机构：
  
  河北北方学院附属第一医院神经内科河北张家口 075000
- 作者简介：
  
  郝旭苗，女，1998—，主要从事神经内科临床研究，E‑mail：18531189983@163.com。
  郝光，E‑mail：haoguang‑2008@163.com。
- 基金信息：
  
  河北省2023年度医学科学研究课题计划(20231410)
- DOI：10.14188/j.1671-8852.2025.0883
  中图分类号： R741
- 收稿：2025-08-04，
  
  纸质出版：2026-10-25
- 稿件说明：
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郝旭苗,马海峰,郝光.急性脑梗死患者血清circ_0003204和miR‑532‑3p水平变化及其与炎性因子水平的相关性[J].武汉大学学报（医学版）,2026,47(10):1359-1365.

HAO Xumiao,MA Haifeng,HAO Guang.Changes in serum circ_0003204 and miR‑532‑3p levels in acute cerebral infarction patients and their correlation with inflammatory factor levels[J].Medical Journal of Wuhan University,2026,47(10):1359-1365.
郝旭苗,马海峰,郝光.急性脑梗死患者血清circ_0003204和miR‑532‑3p水平变化及其与炎性因子水平的相关性[J].武汉大学学报（医学版）,2026,47(10):1359-1365. DOI： 10.14188/j.1671-8852.2025.0883.

HAO Xumiao,MA Haifeng,HAO Guang.Changes in serum circ_0003204 and miR‑532‑3p levels in acute cerebral infarction patients and their correlation with inflammatory factor levels[J].Medical Journal of Wuhan University,2026,47(10):1359-1365. DOI： 10.14188/j.1671-8852.2025.0883.

摘要

目的

探究急性脑梗死（ACI）患者血清circ_0003204和miR‑532‑3p水平变化及其与炎性因子水平的相关性。

方法

选取2023年2月—2025年2月于河北北方学院附属第一医院就诊的ACI患者189例为梗死组，190例健康体检志愿者为对照组。比较两组间一般资料、circ_0003204、miR‑532‑3p和白细胞介素（IL）‑6、IL‑8、C反应蛋白(CRP)、肿瘤坏死因子（TNF）‑α水平。Pearson法分析circ_0003204和miR‑532‑3p水平与IL‑6、IL‑8、CRP、TNF‑α相关性；分析发生ACI的影响因素。根据改良Rankin量表（mRS）将ACI患者分为预后良好组（

=122）和预后不良组（

=67）。比较两组间一般资料和circ_0003204、miR‑532‑3p、IL‑6、IL‑8、CRP、TNF‑α水平。受试者工作特征（ROC）曲线分析血清circ_0003204、miR‑532‑3p水平对ACI患者预后结局的预测价值；决策曲线分析（DCA）评估circ_0003204、miR‑532‑3p及二者联合预测ACI患者预后不良的临床实用性。

结果

与对照组比较，梗死组空腹血糖、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL‑C）、高密度脂蛋白胆固醇（HDL‑C）、circ_0003204、IL‑6、IL‑8、CRP、TNF‑α水平升高，miR‑532‑3p水平降低（

0.05）。circ_0003204水平与IL‑6、IL‑8、CRP、TNF‑α呈正相关（

=0.516、0.467、0.471、0.502，均

0.05），miR‑532‑3p水平与IL‑6、IL‑8、CRP、TNF‑α呈负相关（

=-0.498、-0.439、-0.455、-0.483，均

0.05）。高水平的circ_0003204、IL‑6、IL‑8、CRP、TNF‑α和低水平miR‑532‑3p是发生ACI的危险因素（

=2.763、1.633、1.725、1.626、1.531、0.737，均

0.05）。与预后良好组比较，预后不良组空腹血糖水平、发病至入院时间和血清circ_0003204、IL‑6、IL‑8、CRP、TNF‑α水平升高，miR‑532‑3p水平降低（

0.05）。circ_0003204和miR‑532‑3p联合预测的敏感性为73.13%、特异性为90.16%、ROC曲线下面积（

AUC

）为0.882，二者联合预测的价值高于单独预测的价值（与circ_0003204比较：

=2.534、

=0.011；与miR‑532‑3p比较：

=2.701、

=0.007）。高风险阈值在0.22~0.91时，circ_0003204、miR‑532‑3p二者联合预测ACI患者发生预后不良风险的净获益率较高。

结论

ACI患者血清circ_0003204水平升高，miR‑532‑3p水平降低，且其水平与炎性细胞因子水平密切相关。

Abstract

Objective

To investigate the changes in serum circ_0003204 and miR‑532‑3p levels in patients with acute cerebral infarction (ACI) and their correlation with inflammatory factor levels.

Methods

From February 2023 to February 2025

189 ACI patients who visited the First Affiliated Hospital of Hebei North University served as the infarction group

and 190 healthy volunteers who underwent check ups served as the control group. The general information

circ_0003204

miR‑532‑3p

and levels of IL‑6

IL‑8

CRP

and TNF‑α were compared between two groups. Pearson method was used to analyze the correlation between circ_0003204 and miR‑532‑3p levels with IL‑6

IL‑8

CRP

and TNF‑α; the influencing factors of ACI occurrence were analyzed. Complying with the modified Rankin Scale (mRS)

ACI patients were divided into the good prognosis group (

=122) and the poor prognosis group (

=67). The general information and levels of circ_0003204

miR‑532‑3p

IL‑6

IL‑8

CRP

and TNF‑α were compared between two groups. ROC curve analysis was performed to evaluate the predictive value of serum circ_0003204 and miR‑532‑3p levels for the prognosis of ACI patients. In addition

DCA curve method was performed to discuss and evaluate the clinical utility of circ_0003204

miR‑532‑3p

and their joint prediction for poor prognosis in ACI patients.

Results

Compared with the control group

the infarction group had higher fasting blood glucose

LDL‑C

HDL‑C

circ_0003204

IL‑6

IL‑8

CRP

TNF‑α

and lower miR‑532‑3p (

0.05). The circ_0003204 was positively correlated with IL‑6

IL‑8

CRP

and TNF‑α (

=0.516

0.467

0.471

0.502

all

0.05)

while miR‑532‑3p was negatively correlated with IL‑6

IL‑8

CRP

and TNF‑α

(

=-0.498

-0.439

-0.455

-0.483

all

0.05). High levels of circ_0003204

IL‑6

IL‑8

CRP

TNF‑α

and low level of miR‑532‑3p were risk factors for ACI (

=2.763

1.633

1.725

1.626

1.531

0.737

all

0.05). Compared with the good prognosis group

the poor prognosis group had the fasting blood glucose level

time from onset to admission and higher levels of serum circ_0003204

IL‑6

IL‑8

CRP

TNF‑α

and lower level of miR‑532‑3p (

0.05). The sensitivity

specificity

and

AUC

of the joint prediction of circ_0003204 and miR‑532‑3p were 73.13%

90.16%

and 0.882

respectively

the value of joint prediction of the two was relatively higher

(vs

. circ_0003204 prediction

=2.534

=0.011;

. miR‑532‑3p prediction

=2.701

=0.007). When the high‑risk threshold was between 0.22 and 0.91

the joint of circ_0003204 and miR‑532‑3p had a higher net benefit rate in predicting the risk of poor prognosis in ACI patients.

Conclusion

Serum circ_0003204 is elevated while miR‑532‑3p is decreased in ACI patients. And the difference in their levels is closely related to the levels of inflammatory factors.

关键词

Keywords

references

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