基于孟德尔随机化的血浆脂质与结直肠癌因果关系及代谢物中介研究

陈鑫; 王尤; 周福祥

doi:10.14188/j.1671-8852.2024.0212

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基于孟德尔随机化的血浆脂质与结直肠癌因果关系及代谢物中介研究

临床医学研究 | 更新时间：2026-11-05

- 基于孟德尔随机化的血浆脂质与结直肠癌因果关系及代谢物中介研究
- A Mendelian randomization study on the causal relationship between plasma lipidomes and colorectal cancer, and the mediating effect of metabolites
- 武汉大学学报（医学版） 2025年46卷第5期页码：619-624
- 作者机构：
  
  武汉大学中南医院放化疗科/湖北省肿瘤医院临床研究中心湖北武汉 430071
- 作者简介：
  
  陈鑫，男，1998—，医学硕士生，主要从事消化道肿瘤的研究，E⁃mail：xin.chen@whu.edu.cn
  周福祥，男，1968—，医学博士，主任医师，教授，主要从事恶性肿瘤综合治疗、肿瘤生物治疗、放射损伤机制及其防护等相关研究，E⁃mail：happyzhoufx@sina.com
- 基金信息：
  
  武汉大学中南医院转化医学与交叉学科研究联合基金资助项目(ZNJC202006)
- DOI：10.14188/j.1671-8852.2024.0212
  中图分类号： R735.3
- 收稿：2024-03-27，
  
  纸质出版：2025-05-25
- 稿件说明：
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陈鑫,王尤,周福祥.基于孟德尔随机化的血浆脂质与结直肠癌因果关系及代谢物中介研究[J].武汉大学学报（医学版）,2025,46(05):619-624.

CHEN Xin,WANG You,ZHOU Fuxiang.A Mendelian randomization study on the causal relationship between plasma lipidomes and colorectal cancer, and the mediating effect of metabolites[J].Medical Journal of Wuhan University,2025,46(05):619-624.
陈鑫,王尤,周福祥.基于孟德尔随机化的血浆脂质与结直肠癌因果关系及代谢物中介研究[J].武汉大学学报（医学版）,2025,46(05):619-624. DOI： 10.14188/j.1671-8852.2024.0212.

CHEN Xin,WANG You,ZHOU Fuxiang.A Mendelian randomization study on the causal relationship between plasma lipidomes and colorectal cancer, and the mediating effect of metabolites[J].Medical Journal of Wuhan University,2025,46(05):619-624. DOI： 10.14188/j.1671-8852.2024.0212.

摘要

目的

孟德尔随机化探讨血浆脂质与结直肠癌之间的因果关系，并评估血液代谢物在血浆脂质对结直肠癌风险的中介作用。

方法

基于全基因组关联分析(GWAS)数据库，对血浆脂质与结直肠癌进行双样本孟德尔随机化分析。设置最显著因素磷脂酰胆碱（20:4_0:0）为结局进行反向孟德尔随机化分析和并估算代谢物中介作用，采用5种孟德尔随机化分析方法（逆方差加权法、MR⁃Egger回归法、加权中位数法、加权模型法和简单模型法）。

结果

33种血浆脂质和结直肠癌具有潜在的因果关系（

0.05），亚油醇乙醇胺、N⁃乙酰天冬氨酰谷氨酸在磷脂酰胆碱（20:4_0:0）与结直肠癌风险的机制中起到中介作用。

结论

33种血浆脂质可能与结直肠癌存在因果关联。

Abstract

Objective

To investigate the causal relationship between plasma lipidomes and colorectal cancer based on the Mendelian randomization method

and to evaluate the mediating role of blood metabolites in the association between plasma lipidomes and colorectal cancer risk.

Methods

A two⁃sample Mendelian randomisation analysis of plasma lipids and colorectal cancer was conducted based on genome⁃wide association analysis (GWAS) database. Inverse variance⁃weighted method

MR⁃Egger regression

weighted median

weighted model

and simple model were adopted for Mendelian randomization analysis

with the most significant factor

phosphatidylcholine (20:4_0:0)

set as the outcome for reverse Mendelian randomization analysis and estimation of metabolite mediation.

Results

It was observed that 33 plasma lipids showed potential causal relationships with colorec

tal cancer (

0.05). Linoleoyl ethanolamide and N⁃acetyl⁃aspartyl⁃glutamate mediated the effect of phosphatidylcholine (20:4_0:0) on colorectal cancer.

Conclusion

Thirty⁃three plasma lipids have a potential causal relationship with colorectal cancer.

关键词

Keywords

references

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