1.安徽医科大学第二附属医院急诊外科,安徽 合肥 230601
2.安徽医科大学微创介入研究中心,安徽 合肥 230601
袁春雨,硕士,住院医师,主要从事急腹症和创伤方面的研究,Email:1176708313@qq.com
李贺,Email:422600897@qq.com
收稿:2024-05-03,
纸质出版:2024-12-22
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袁春雨,尹纯林,李贺.急性阑尾炎伴穿孔的相关危险因素分析[J].腹部外科,2024,37(06):413-417.
Yuan Chunyu,Yin Chunlin,Li He.Analysis of risk factors correlated with acute appendicitis with perforation[J].J Abdominal Surg,2024,37(06):413-417.
袁春雨,尹纯林,李贺.急性阑尾炎伴穿孔的相关危险因素分析[J].腹部外科,2024,37(06):413-417. DOI: 10.3969/j.issn.1003-5591.2024.06.004.
Yuan Chunyu,Yin Chunlin,Li He.Analysis of risk factors correlated with acute appendicitis with perforation[J].J Abdominal Surg,2024,37(06):413-417. DOI: 10.3969/j.issn.1003-5591.2024.06.004.
目的
2
探讨急性阑尾炎病人并发穿孔的相关危险因素。
方法
2
以安徽医科大学第二附属医院2023年1月至6月期间收治的212例急性阑尾炎病人为研究对象,结合手术中观察阑尾有无穿孔和术后送检阑尾病理结果,分成急性阑尾炎未穿孔组(
n
=169)和急性阑尾炎伴穿孔组(
n
=43)。收集病人入院时一般资料(年龄、性别、院前发病持续时间等)、血液检测指标(血常规、总胆红素和D-二聚体等相关指标)和影像学指标(阑尾是否含有粪石和是否合并腹腔积液),进行两组间比较,对有意义的指标进行多因素logistic回归分析和绘制受试者操作特征曲线。
结果
2
212例急性阑尾炎病人中穿孔43例,占20.3%,对各指标进行单因素和多因素logistic回归分析得出症状持续时间、体温≥38 ℃、阑尾是否有粪石、是否合并腹腔积液以及血C-反应蛋白(CRP)水平是急性阑尾炎伴穿孔的独立危险因素(均
P
<0.05),并进一步绘制受试者操作特征曲线显示,单指标预测中症状持续时间、是否合并腹腔积液和血CRP水平曲线下面积依次为0.827、0.853和0.810(均
P
<0.05)。各指标联合预测阑尾炎穿孔风险时曲线下面积为0.962,敏感度为0.884,特异度为0.893。
结论
2
急性阑尾炎病人发病时症状持续时间、体温≥38 ℃、阑尾是否含有粪石、是否合并腹腔积液及入院时血CRP水平是急性阑尾炎伴穿孔病人的独立危险因素,各指标联合预测阑尾穿孔风险价值更高。
Objective
2
To explore the risk factors of acute appendicitis (AA) with perforation.
Methods
2
From January to June 2023, a total of 212 hospitalized AA patients were selected as study subjects. According to the observation o
f appendix and pathological results, they were assigned into two groups of non-perforated (
n
=169) and perforated (
n
=43). Demographic profiles (e.g. gender, age
&
duration of onset), blood test parameters (e.g. blood routine, total bilirubin
&
D-dimer) and imaging findings (whether or not fecalith within appendix and ascites in abdominal cavity) were compared between two groups. The influencing factors of perforated AA were examined by multivariate Logistic regression analysis and receiver operating characteristic (ROC) curve.
Results
2
There were 43 cases of perforated AA with a perforation rate of 20.3%. Longer symptomatic duration, fever (axillary temperature ≥38 ℃), appendiceal fecalith on imaging, ascites on imaging and elevated level of C-reactive protein (CRP) were independent risk factors for perforated AA were examined by single factor and multiple factor Logistic regression (
P
<
0.05). The area under the ROC curve of longer symptomatic duration, ascites and CRP level were 0.827, 0.853 and 0.810 (
P
<
0.05). When all parameters were combined for prediction, AUC was 0.962 with a sensitivity of 0.884 and a specificity of 0.893.
Conclusion
2
Longer symptomatic duration, fever (axillary temperature ≥38 ℃), appendiceal fecalith on imaging, ascites on imaging and elevated CRP level are independent risk factors for perforated AA. There is a higher value when all parameters are combined for assessments.
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