蛋白质翻译后修饰在心血管疾病中的研究进展

陈哲; 李飞

doi:10.14188/j.1671-8852.2026.0103

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蛋白质翻译后修饰在心血管疾病中的研究进展

综述 | 更新时间：2026-11-05

- 蛋白质翻译后修饰在心血管疾病中的研究进展
- Research progress on post‑translational modifications of proteins in cardiovascular diseases
- 武汉大学学报（医学版） 2026年47卷第10期页码：1415-1420
- 作者机构：
  
  华中科技大学同济医学院附属协和医院心血管外科湖北武汉 430022
- 作者简介：
  
  陈哲，男，1999—,医学硕士生，主要从事主动脉瓣钙化的基础与临床研究，E‑mail：cz09150806@163.com。
  李飞，E‑mail：lifei_union@hust.edu.cn。
- 基金信息：
  
  国家自然科学基金资助项目(82322007);国家重点研发计划资助项目(2022YFC2503401)
- DOI：10.14188/j.1671-8852.2026.0103
  中图分类号： R541
- 收稿：2026-01-29，
  
  纸质出版：2026-10-25
- 稿件说明：
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陈哲,李飞.蛋白质翻译后修饰在心血管疾病中的研究进展[J].武汉大学学报（医学版）,2026,47(10):1415-1420.

CHEN Zhe,LI Fei.Research progress on post‑translational modifications of proteins in cardiovascular diseases[J].Medical Journal of Wuhan University,2026,47(10):1415-1420.
陈哲,李飞.蛋白质翻译后修饰在心血管疾病中的研究进展[J].武汉大学学报（医学版）,2026,47(10):1415-1420. DOI： 10.14188/j.1671-8852.2026.0103.

CHEN Zhe,LI Fei.Research progress on post‑translational modifications of proteins in cardiovascular diseases[J].Medical Journal of Wuhan University,2026,47(10):1415-1420. DOI： 10.14188/j.1671-8852.2026.0103.

摘要

蛋白质翻译后修饰（PTM）是蛋白质合成后通过共价连接功能基团调控结构与功能的关键机制，其动态平衡与心血管系统稳态维持密切相关。本文系统综述了传统修饰（磷酸化、乙酰化等）与新兴酰化修饰（琥珀酰化、乳酸化等）在动脉粥样硬化、心肌梗死、高血压、心力衰竭等心血管疾病（CVD）中的作用机制，并总结靶向PTM的临床转化潜力与研究瓶颈，为CVD的精准诊断与治疗提供新思路。

Abstract

Post⁃translational modifications (PTMs) are key mechanisms that regulate protein structure and function through the covalent attachment of functional groups after protein synthesis. Their dynamic balance is closely linked to the maintenance of cardiovascular homeostasis. This review systematically summarizes the roles and mechanisms of both classical PTMs (e.g.

phosphorylation and acetylation) and emerging acylation modifications (e.g.

succinylation and lactylation) in various cardiovascular diseases (CVDs)

such as atherosclerosis

myocardial infarction

hypertension

and heart failure. It further summarizes the translational potential of targeting PTMs as therapeutic targets in clinical practice

addresses current research bottlenecks

and aims to provide new insights into the precise diagnosis and treatment of cardiovascular diseases.

关键词

Keywords

references

GBD 2021 Causes of Death Collaborators . Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990‑2021: A systematic analysis for the Global Burden of Disease Study 2021 [J ] . Lancet , 2024 , 403 ( 10440 ): 2100 ‑ 2132 .

WU X M , XU M Y , GENG M Y , et al . Targeting protein modifications in metabolic diseases: Molecular mechanisms and targeted therapies [J ] . Signal Transduct Target Ther , 2023 , 8 ( 1 ): 220 .

GEFFEN Y , ANAND S , AKIYAMA Y , et al . Pan‑cancer analysis of post‑translational modifications reveals shared patterns of protein regulation [J ] . Cell , 2023 , 186 ( 18 ): 3945 ‑ 3967.e26 .

WU X , WANG B , LI J X , et al . Inhibition of PRMT5 attenuates cerebral ischemia/reperfusion⁃induced inflammation and pyroptosis through suppression of NF⁃κB/NLRP3 axis [J ] . Neurosci Lett , 2022 , 776 : 136576 .

DENG Y , LIU X , XIE M , et al . Obesit y enables NLRP3 activation and induces myocardial fibrosis via hyperacetylation of HADHa [J ] . Diabetes , 2023 , 72 ( 11 ): 1597 ‑ 1608 .

MAGALHÃES A , DUARTE H O , REIS C A . The role of O‑glycosylation in human disease [J ] . Mol Aspects Med , 2021 , 79 : 100964 .

LEE J M , HAMMARÉN H M , SAVITSKI M M , et al . Control of protein stability by post‑translational modifications [J ] . Nat Commun , 2023 , 14 ( 1 ): 201 .

WEI H M , HUO P , LIU S , et al . Posttranslational modifications in pathogenesis of PCOS [J ] . Front Endocrinol , 2022 , 13 : 1024320 .

VALENCIA‑SÁNCHEZ M I , DE IOANNES P , WANG M , et al . Regulation of the Dot1 histone H3K79 methyltransferase by histone H4K16 acetylation [J ] . Science , 2021 , 371 ( 6527 ): eabc6663 .

LI X X , WANG L X , WANG M , et al . Global analysis of protein succinylation modification of Nostoc flagelliforme in response to dehydration [J ] . J Proteom , 2021 , 237 : 104149 .

SOSLAU G . Platelet protein synthesis, regulation, and post‑translational modifications: Mechanics and function [J ] . Crit Rev Biochem Mol Biol , 2023 , 58 ( 2/3/4/5/6 ): 99 ‑ 117 .

ZHANG Y J , HU W G , LI H B . RNA modification‑mediated translational control in immune cells [J ] . RNA Biol , 2023 , 20 ( 1 ): 603 ‑ 613 .

KOKKINIDIS M , GLYKOS N M , FADOULOGLOU V E . Catalytic activity regulation through post‑translational modification: The expanding universe of protein diversity [J ] . Adv Protein Chem Struct Biol , 2020 , 122 : 97 ‑ 125 .

WANG S , OSGOOD A O , CHATTERJEE A . Uncovering post‑translational modification‑associated protein⁃protein interactions [J ] . Curr Opin Struct Biol , 2022 , 74 : 102352 .

王玲玲 , 谢慧仪 , 陈绮泠 , 等 . 动脉粥样硬化发病机制与治疗药物的研究进展 [J ] . 广东医科大学学报 , 2023 , 41 ( 5 ): 589 ‑ 594 .

WANG L L , XIE H Y , CHEN Q L , et al . Advances on pathogenesis and drugs of atherosclerosis [J ] . J Guangdong Med Coll , 2023 , 41 ( 5 ): 589 ‑ 594 .

刘润民 , 吴克寒 , 杨高伟 , 等 . 血管细胞自噬功能失调在动脉粥样硬化发病机制中的研究进展 [J ] . 解放军医学杂志 , 2024 , 49 ( 10 ): 1201 ‑ 1206 .

LIU R M , WU K H , YANG G W , et al . Research progress on autophagy dysfunction of vascular cells in the pathogenesis of atherosclerosis [J ] . Med J Chin People's Liberation Army , 2024 , 49 ( 10 ): 1201 ‑ 1206 .

CAI Z J , DING Y , ZHANG M , et al . Ablation of adenosine monophosphate‑activated protein kinase α1 in vascular smooth muscle cells promotes diet‑induced atherosclerotic calcification in vivo [J ] . Circ Res , 2016 , 119 ( 3 ): 422 ‑ 433 .

LOWENSTEIN C J . Nitric oxide regulation of protein trafficking in the cardiovascular system [J ] . Cardiovasc Res , 2007 , 75 ( 2 ): 240 ‑ 246 .

胡彩英 , 文斌 . 组蛋白修饰调控急性心肌梗死发病机制的研究进展 [J ] . 华中科技大学学报(医学版) , 2024 , 53 ( 4 ): 535 ‑ 538 .

HU C Y , WEN B . Research progress on histones modification regulating the pathogenesis in acute myocardial infarction [J ] . Acta Med Univ Sci Technol Huazhong , 2024 , 53 ( 4 ): 535 ‑ 538 .

董磊 , 江新泉 . 急性心肌梗死的发病机制及诊疗研究进展 [J ] . 山东第一医科大学(山东省医学科学院)学报 , 2021 , 42 ( 6 ): 476 ‑ 480 .

DONG L , JIANG X Q . Research progress on pathogenesis, diagnosis and treatment of acute myocardial infarction [J ] . J Shandong First Med Univ Shandong Acad Med Sci , 2021 , 42 ( 6 ): 476 ‑ 480 .

BOYLSTON J A , SUN J H , CHEN Y , et al . Characterization of the cardiac succinylome and its role in ischemia⁃reperfusion injury [J ] . J Mol Cell Cardiol , 2015 , 88 : 73 ‑ 81 .

CHOUCHANI E T , PELL V R , GAUDE E , et al . Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS [J ] . Nature , 2014 , 515 ( 7527 ): 431 ‑ 435 .

YAO L Y , HE F N , ZHAO Q Y , et al . Spatial multiplexed protein profiling of cardiac ischemia‑reperfusion injury [J ] . Circ Res , 2023 , 133 ( 1 ): 86 ‑ 103 .

王华 , 刘宇佳 , 杨杰孚 . 心力衰竭流行病学 [J ] . 临床心血管病杂志 , 2023 , 39 ( 4 ): 243 ‑ 247 .

WANG H , LIU Y J , YANG J F . Epidemiology of heart failure [J ] . J Clin Cardiol , 2023 , 39 ( 4 ): 243 ‑ 247 .

BRAGAZZI N L , ZHONG W , SHU J X , et al . Burden of heart failure and underlying causes in 195 countries and territories from 1990 to 2017 [J ] . Eur J Prev Cardiol , 2021 , 28 ( 15 ): 1682 ‑ 1690 .

LI M H , SUN G Z , WANG P B , et al . Research progress of Nedd4L in cardiovascular diseases [J ] . Cell Death Discov , 2022 , 8 ( 1 ): 206 .

YUAN L , BU S C , DU M , et al . RNF207 exacerbates pathological cardiac hypertrophy via post‑translational modification of TAB1 [J ] . Cardiovasc Res , 2023 , 119 ( 1 ): 183 ‑ 194 .

OH J G , WATANABE S , LEE A , et al . miR‑146a suppresses SUMO1 expression and induces cardiac dysfunction in maladaptive hypertrophy [J ] . Circ Res , 2018 , 123 ( 6 ): 673 ‑ 685 .

TANG X , ZHAO S , LIU J Q , et al . Mitochondrial GSNOR alleviates cardiac dysfunction via ANT1 denitrosylation [J ] . Circ Res , 2023 , 133 ( 3 ): 220 ‑ 236 .

DUBOIS‑DERUY E , BELLIARD A , MULDER P , et al . Interplay between troponin T phosphorylation and O‑N‑acetylglucosaminylation in ischaemic heart failure [J ] . Cardiovasc Res , 2015 , 107 ( 1 ): 56 ‑ 65 .

MENDLER L , BRAUN T , MÜLLER S . The ubiquitin‑like SUMO system and heart function: From development to disease [J ] . Circ Res , 2016 , 118 ( 1 ): 132 ‑ 144 .

王嘉怡 , 曲艺 , 张增磊 , 等 . 高血压性心脏病的诊断及治疗研究进展 [J ] . 中国分子心脏病学杂志 , 2025 , 25 ( 2 ): 6753 ‑ 6764 .

WANG J Y , QU Y , ZHANG Z L , et al . Advances on diagnosis and treatment of hypertensive heart disease [J ] . Mol Cardiol China , 2025 , 25 ( 2 ): 6753 ‑ 6764 .

中华医学会心血管病学分会 , 中国医师协会心血管内科医师分会 , 中国医师协会心力衰竭专业委员会 , 等 . 中国心力衰竭诊断和治疗指南2024 [J ] . 中华心血管病杂志 , 2024 , 52 ( 3 ): 235 ‑ 275 .

Cardiology Branch of Chinese Medical Association , Cardiology Physicians Branch of Chinese Medical Doctor Association , Heart Failure Professional Committee of Chinese Medical Doctor Association , et al . Chinese guidelines for the diagnosis and treatment of heart failure 2024 [J ] . Chin J Cardiol , 2024 , 52 ( 3 ): 235 ‑ 275 .

DÍEZ J , BUTLER J . Growing heart failure burden of hypertensive heart disease: A call to action [J ] . Hypertension , 2023 , 80 ( 1 ): 13 ‑ 21 .

ZHANG Y , ZHANG N J , ZOU Y M , et al . Deacetylation of Septin4 by SIRT2 (silent mating type information regulation 2 homolog‑2) mitigates damaging of hypertensive nephropathy [J ] . Circ Res , 2023 , 132 ( 5 ): 601 ‑ 624 .

ZHU L , LIU Y P , HUANG Y T , et al . Cellular and molecular biology of posttranslational modifications in cardiovascular disease [J ] . Biomed Pharmacother , 2024 , 179 : 117374 .

PARK J , CHEN Y , TISHKOFF D X , et al . SIRT5‑mediated lysine desuccinylation impacts diverse metabolic pathways [J ] . Mol Cell , 2013 , 50 ( 6 ): 919 ‑ 930 .

SREEJIT G , ABDEL‑LATIF A , ATHMANATHAN B , et al . Neutrophil‑derived S100A8/A9 amplify granulopoiesis after myocardial infarction [J ] . Circulation , 2020 , 141 ( 13 ): 1080 ‑ 1094 .

STASTNA M . Post‑translational modifications of proteins in cardiovascular diseases examined by proteomic approaches [J ] . FEBS J , 2025 , 292 ( 1 ): 28 ‑ 46 .

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