经导管缘对缘修复术短期疗效与安全性的单中心回顾性分析

谭戈; 熊乐财; 陈星; 王艺; 刘金平; 张力

doi:10.14188/j.1671-8852.2025.1383

您当前的位置：

首页 >

文章列表页 >

经导管缘对缘修复术短期疗效与安全性的单中心回顾性分析

临床医学研究 | 更新时间：2026-11-05

- 经导管缘对缘修复术短期疗效与安全性的单中心回顾性分析
- Short‑term efficacy and safety of transcatheter edge‑to‑edge repair: A single⁃center retrospective analysis
- 武汉大学学报（医学版） 2026年47卷第10期页码：1391-1398
- 作者机构：
  
  武汉大学中南医院心血管外科湖北武汉 430071
- 作者简介：
  
  谭戈，男，1999-，医学硕士，主要从事瓣膜疾病相关研究，E‑mail：1317227600@qq.com。
  张力，E‑mail：zl0104@whu.edu.cn。
- 基金信息：
- DOI：10.14188/j.1671-8852.2025.1383
  中图分类号： R654.2
- 收稿：2025-11-18，
  
  纸质出版：2026-10-25
- 稿件说明：
移动端阅览
谭戈,熊乐财,陈星等.经导管缘对缘修复术短期疗效与安全性的单中心回顾性分析[J].武汉大学学报（医学版）,2026,47(10):1391-1398.

TAN Ge,XIONG Lecai,CHEN Xing,et al.Short‑term efficacy and safety of transcatheter edge‑to‑edge repair: A single⁃center retrospective analysis[J].Medical Journal of Wuhan University,2026,47(10):1391-1398.
谭戈,熊乐财,陈星等.经导管缘对缘修复术短期疗效与安全性的单中心回顾性分析[J].武汉大学学报（医学版）,2026,47(10):1391-1398. DOI： 10.14188/j.1671-8852.2025.1383.

TAN Ge,XIONG Lecai,CHEN Xing,et al.Short‑term efficacy and safety of transcatheter edge‑to‑edge repair: A single⁃center retrospective analysis[J].Medical Journal of Wuhan University,2026,47(10):1391-1398. DOI： 10.14188/j.1671-8852.2025.1383.

摘要

目的

评价经导管缘对缘修复术(TEER)对中度至重度二尖瓣反流(MR)患者的短期有效性及安全性。

方法

回顾性分析2022年4月至2025年8月在武汉大学中南医院心外科行TEER的二尖瓣反流患者的临床资料，包括术前基线临床及超声心动图资料、术中资料及术后1个月随访资料。

结果

共纳入49名患者（男性30例，女性19例），均完成1个月随访。主要疗效结局是30 d时MR≤2+；纽约心脏病协会(NYHA)心功能改善≥1级或6 min步行试验距离(6MWD)增加>50 m；安全性结局是术后30 d内新发生的主要不良心脑血管事件(MACCE)，定义为心血管相关性死亡、非致死性卒中、心肌梗死、心衰、瓣膜功能再障碍和肾功能障碍的复合。在手术的49名患者中，术后30 d复查二尖瓣反流≤2+者为100%；术后30 d内新发生的MACCE发生率为4.08%，全部因不稳定心绞痛、心衰而再次住院，无心血管死亡、卒中或心肌梗死事件发生。

结论

TEER可有效减少二尖瓣反流，并具有良好的短期安全性。

Abstract

Objective

To evaluate the short‑term safety and effectiveness of transcatheter edge‑to‑edge repair (TEER) in patients with moderate‑to‑severe mitral regurgitation (MR).

Methods

A retrospective analysis was conducted on clinical data from patients with moderate‑to‑severe MR who underwent TEER in the Department of Cardiovascular Surgery of Zhongnan Hospital of Wuhan University

between April 2022 and August 2025. Data were collected including pre‑operative clinical and echocardiographic parameters

intraoperative records

and 1‑month postoperative follow‑up information.

Results

A total of 49 patients (30 male

19 female) were enrolled

and all cases completed 1‑month follow‑up. The primary efficacy endpoint was MR grade ≤2+ at 30 days. Secondary efficacy outcomes included an improvement of ≥1 class in New York Heart Association (NYHA) functional classification or an increase of >50 meters in the 6‑minute walk test distance (6MWD). The safety endpoint was the occurrence of new‑onset major adverse cardiac and cerebrovascular events (MACCE) within 30 days post‑procedure

a composite of cardiovascular mortality

non‑fatal stroke

myocardial infarction

heart failure rehospitalization

valvular dysfunction

and renal dysfunction. Among the 49 patients

100% achieved MR grade ≤2+ at the 30‑day follow‑up. The 30‑day MACCE rate was 4.08%

with all events being rehospitalizations due to unstable angina or heart failure. No cardiovascular deaths

strokes

or myocardial infarctions occurred.

Conclusion

The results indicate that TEER effectively reduces mitral regurgitation and has a favorable short‑term safety profile.

关键词

Keywords

references

BARTKO P E , HEITZINGER G , PAVO N , et al . Burden, treatment use, and outcome of secondary mitral regurgitation across the spectrum of heart failure: Observational cohort study [J ] . BMJ , 2021 , 373 : n1421 .

STONE G W , LINDENFELD J , ABRAHAM W T , et al . Transcatheter mitral‑valve repair in patients with heart failure [J ] . N Engl J Med , 2018 , 379 ( 24 ): 2307 ‑ 2318 .

OBADIA J F , MESSIKA‑ZEITOUN D , LEURENT G , et al . Percutaneous repair or medical treatment for secondary mitral regurgitation [J ] . N Engl J Med , 2018 , 379 ( 24 ): 2297 ‑ 2306 .

LANCELLOTTI P , DULGHERU R E . 2025 European (ESC/EACTS) guidelines for the management of valvular heart disease: Updates and perspectives [J ] . Rev Med Liege , 2025 , 80 ( 10 ): 628 ‑ 635 .

谢雅舒 . 经导管二尖瓣反流治疗评估的现状与展望 [J ] . 复旦学报(医学版) , 2020 , 47 ( 5 ): 778 ‑ 782 .

XIE Y S . Evaluation of transcatheter mitral regurgitation therapeutics: Current situation and prospect [J ] . Fudan Univ J Med Sci , 2020 , 47 ( 5 ): 778 ‑ 782 .

中国医师协会心血管内科医师分会 , 中国康复医学会心脏介入治疗和康复专业委员会 , 中国医院协会心脏康复管理专业委员会 . 经导管二尖瓣缘对缘修复术患者心脏康复中国专家共识 [J ] . 中国介入心脏病学杂志 , 2023 , 31 ( 4 ): 252 ‑ 265 .

Cardiovascular Physician Branch of Chinese Medical Association , Cardiac Interventional Therapy Rehabilitation Professional Committee of Chinese Association of Rehabilitation Medicine , Cardiac Rehabilitation Management Committee of Chinese Hospital Association . China expert consensus statement on cardiac rehabilitation management of patients with transcatheter mitral valve edge‑to‑edge repair [J ] . Chin J Interv Cardiol , 2023 , 31 ( 4 ): 252 ‑ 265 .

KAR S , VON BARDELEBEN R S , ROTTBAUER W , et al . Contemporary outcomes following transcatheter edge‑to‑edge repair 1‑year results from the EXPAND study [J ] . JACC Cardiovasc Interv , 2023 , 16 ( 5 ): 589 ‑ 602 .

马云龙 , 李瑞锋 , 何明俊 , 等 . 经导管缘对缘修复术治疗中重度二尖瓣反流患者的近期临床疗效 [J ] . 浙江大学学报(医学版) , 2025 , 54 ( 2 ): 204 ⁃ 212 .

MA Y L , LI R F , HE M J , et al . Short‑term clinical efficacy of transcatheter edge‑to‑edge repair for moderate to severe mitral regurgitation [J ] . Journal of Zhejiang University (Medical Sciences) , 2025 , 54 ( 2 ): 204 ‑ 212 .

KASSAR M , OVSENIK A , MADHKOUR R , et al . Hyperacute effects of mitral transcatheter edge‑to‑edge repair on left ventricular volumes and functions [J ] . Am J Cardiol , 2025 , 241 : 9 ‑ 16 .

GRAYBURN P A , SANNINO A , PACKER M . Proportionate and disproportionate functional mitral regurgitation: A new conceptual framework that reconciles the results of the MITRA‑FR and COAPT trials [J ] . JACC Cardiovasc Imaging , 2019 , 12 ( 2 ): 353 ‑ 362 .

KONSTAM M A , KIERNAN M S , BERNSTEIN D , et al . Evaluation and management of right‑sided heart failure: A scientific statement from the American heart association [J ] . Circulation , 2018 , 137 ( 20 ): e578 ‑ e622 .

RICCARDI M , PABON M A , BHATT A S , et al . Heart failure with improved ejection fraction: Definitions, epidemiology, and management [J ] . J Am Coll Cardiol , 2025 , 85 ( 24 ): 2401 ‑ 2415 .

ONO S , KUBO S , MARUO T , et al . Predictors and clinical impact of worsening left ventricular ejection fraction after mitral transcatheter edge‑to‑edge repair [J ] . EuroIntervention , 2024 , 20 ( 22 ): 1430 ‑ 1441 .

LIDVIHURIN A S , FIKRI Y A . The predictive role of N‑terminal pro‑B‑type natriuretic peptide in assessing outcomes for atrial fibrillation patients, with or without heart failure: A comprehensive systematic review and meta‑analysis [J ] . Cardiol Plus , 2024 , 9 ( 1 ): 32 ‑ 40 .

ROBLES‑MEZCUA A , JANUZZI J L , PAVÓN‑MORÓN F J , et al . Effects of sacubitril/valsartan on cardiac remodeling in heart failure with reduced ejection fraction: An integrated study of molecular biomarkers and imaging techniques [J ] . Biomed Pharmacother , 2025 , 183 : 117874 .

AGUIRRE‑URRETA M I , RÖNKKÖ M , MCINTOSH C N . Too small to succeed: Small samples and the p‑value problem [J ] . SIGMIS Database , 2024 , 55 ( 3 ): 12 ‑ 49 .

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

超声⁃CT多模态融合成像构建器质性二尖瓣关闭不全个体化计算流体动力学模型的可行性研究

47例酒精戒断震颤谵妄合并肺部感染患者药物治疗的临床分析

新型冠状病毒对睾丸功能的影响

中华精神科杂志10年间药物疗效研究资料分析

胃癌前状态和癌前病变随访现状及影响因素研究进展