扫频光学相干断层扫描及血管成像技术在评估不同屈光度学龄期儿童黄斑区视网膜、脉络膜参数的应用

瞿婕; 王漫; 吴国欢; 王姗; 秦惠; 张莹

doi:10.14188/j.1671-8852.2025.0228

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扫频光学相干断层扫描及血管成像技术在评估不同屈光度学龄期儿童黄斑区视网膜、脉络膜参数的应用

临床医学研究 | 更新时间：2026-11-05

- 扫频光学相干断层扫描及血管成像技术在评估不同屈光度学龄期儿童黄斑区视网膜、脉络膜参数的应用
  增强出版
- Application of swept‐source optical coherence tomography/optical coherence tomography angiography in evaluating macular retinal and choroidal parameters in school‐age children with various refractive errors
- 武汉大学学报（医学版） 2026年47卷第10期页码：1336-1344
- 作者机构：
  
  武汉大学附属爱尔眼科医院（武汉爱尔眼科医院）湖北武汉 430064
- 作者简介：
  
  瞿婕，女，1998—，医学硕士，主治医师，主要从事眼底疾病相关研究，E‐mail：qj11341373357@163.com。
  张莹，E‐mail：7814141@qq.com。
- 基金信息：
  
  国家自然科学基金资助项目(62176190);湖南省自然科学基金项目(2024JJ904)
- DOI：10.14188/j.1671-8852.2025.0228
  中图分类号： R77
- 收稿：2025-03-15，
  
  纸质出版：2026-10-25
- 稿件说明：
移动端阅览
瞿婕,王漫,吴国欢等.扫频光学相干断层扫描及血管成像技术在评估不同屈光度学龄期儿童黄斑区视网膜、脉络膜参数的应用[J].武汉大学学报（医学版）,2026,47(10):1336-1344.

QU Jie,WANG Man,WU Guohuan,et al.Application of swept‐source optical coherence tomography/optical coherence tomography angiography in evaluating macular retinal and choroidal parameters in school‐age children with various refractive errors[J].Medical Journal of Wuhan University,2026,47(10):1336-1344.
瞿婕,王漫,吴国欢等.扫频光学相干断层扫描及血管成像技术在评估不同屈光度学龄期儿童黄斑区视网膜、脉络膜参数的应用[J].武汉大学学报（医学版）,2026,47(10):1336-1344. DOI： 10.14188/j.1671-8852.2025.0228.

QU Jie,WANG Man,WU Guohuan,et al.Application of swept‐source optical coherence tomography/optical coherence tomography angiography in evaluating macular retinal and choroidal parameters in school‐age children with various refractive errors[J].Medical Journal of Wuhan University,2026,47(10):1336-1344. DOI： 10.14188/j.1671-8852.2025.0228.

摘要

目的

评估不同屈光度学龄期儿童黄斑区视网膜及脉络膜参数，并探究其与眼轴长度（AL）、等效球镜（SE）、角膜曲率（CC）的相关性。

方法

本研究纳入2021年4月至6月武汉大学附属爱尔眼科医院就诊的学龄期儿童305例（305眼），根据SE分为低度远视组（64眼，+0.50 D≤SE<+3.00 D）、正视组（37眼，-0.50 D<SE<+0.50 D）、低度近视组（158眼，-3.00 D≤SE<-0.50 D）、中度近视组（46眼，-6.00 D≤SE<-3.00 D）。所有受试者均行验光、AL和CC测量及扫频光学相干断层扫描及血管成像（SS‐OCT/OCTA）检查，采集以中心凹为中心6 mm内的视网膜厚度（RT）、浅层毛细血管密度（SVD）及深层毛细血管密度（DVD）、脉络膜厚度（CT）、脉络膜毛细血管密度（CVD），采用广义估计方程比较组间差异，Spearman分析相关性。

结果

不同屈光度组儿童中心凹及旁中心凹RT、SVD、CT，及部分方位DVD、CVD差异显著（

0.05或

0.01）；中心凹RT、SVD、DVD与AL正相关

、与SE负相关，旁中心凹上述参数与AL负相关、与SE正相关，且相关性存在区域差异。

结论

学龄期儿童近视度数增加时，中心凹RT及视网膜毛细血管密度代偿性升高，部分旁中心凹RT及毛细血管密度显著降低；中心凹与旁中心凹CT随近视进展降低，CVD无明显改变。

Abstract

Objective

To evaluate macular retinal and choroidal parameters in school⁃age children with various refractive errors

and to explore their correlations with axial length (AL)

spherical equivalent (SE) and corneal curvature (CC).

Methods

A total of 305 school⁃age children (305 eyes) who underwent ophthalmic examinations at Wuhan Aier Eye Hospital from April to June 2021 were enrolled in this study. According to SE values

the subjects were divided into four groups: low hyperopia group (64 eyes

0.50 D≤SE<3.00 D)

emmetropia group (37 eyes

-0.50 D<SE<+0.50 D)

low myopia group (158 eyes

-3.00 D<SE≤-0.50 D)

and moderate myopia group (46 eyes

-6.00 D<SE≤-3.00 D). All subjects underwent refraction

AL measurement

CC measurement

and swept‐source optical coherence tomography/optical coherence tomography angiography (SS‐OCT/OCTA) examination. Parameters within a 6 mm diameter centered on the fovea were collected

including retinal thickness (RT)

superficial vascular density (SVD)

deep vascular density (DVD)

choroidal thickness (CT)

and choroidal vascular density (CVD). Generalized Estimating Equations were used to compare differences among groups

and Spearman correlation analysis was applied to explore correlations.

Results

Significant differences were observed in RT

SVD

and CT at the fovea and parafovea

as well as in DVD and CVD at some parafoveal locations

among children with different refractive errors (

0.05 or

0.01).At the fovea

SVD

and DVD were positively correlated with AL and negatively correlated with SE. At the parafovea

these parameters showed inverse correlations with AL and positive correlations with SE

with regiona

l differences.

Conclusion

With increasing myopia severity in school⁃age children

foveal RT and retinal vascular density demonstrate a compensatory increase

whereas certain parafoveal RT and vascular density decrease. CT at both the fovea and parafovea decreases with myopia progression

but no significant change was observed in CVD.

关键词

Keywords

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