未缺血脑区对脑缺血核心区的保护作用及其调控机制：围术期脑缺血防治

吴科帆; 王宇轩; 邱珍; 侯家保; 赵博; 雷少青; 夏中元

doi:10.14188/j.1671-8852.2025.0049

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未缺血脑区对脑缺血核心区的保护作用及其调控机制：围术期脑缺血防治

综述 | 更新时间：2026-11-06

- 未缺血脑区对脑缺血核心区的保护作用及其调控机制：围术期脑缺血防治
- Protective effects of remote brain regions on the ischemic core and their regulatory mechanisms: Perioperative prevention and treatment of cerebral ischemia
- 武汉大学学报（医学版） 2025年46卷第12期页码：1645-1652
- 作者机构：
  
  武汉大学人民医院麻醉科湖北武汉 430060
- 作者简介：
  
  吴科帆，男，1996—，医学博士，主要从事围术期重要器官灌注保护研究, E‑mail：wkf7788@whu.edu.cn
  夏中元，男，1966—,教授，一级主任医师，博士生导师，主要从事围术期重要器官灌注保护研究, E‑mail： xiazhongyuan2005@aliyun
- 基金信息：
  
  国家自然科学基金资助项目(82172160;88202408);国家重点研发计划资助项目(2020YFC2009002)
- DOI：10.14188/j.1671-8852.2025.0049
  中图分类号： R614
- 收稿：2025-01-12，
  
  纸质出版：2025-12-25
- 稿件说明：
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吴科帆,王宇轩,邱珍等.未缺血脑区对脑缺血核心区的保护作用及其调控机制：围术期脑缺血防治[J].武汉大学学报（医学版）,2025,46(12):1645-1652.

WU Kefan,WANG Yuxuan,QIU Zhen,et al.Protective effects of remote brain regions on the ischemic core and their regulatory mechanisms: Perioperative prevention and treatment of cerebral ischemia[J].Medical Journal of Wuhan University,2025,46(12):1645-1652.
吴科帆,王宇轩,邱珍等.未缺血脑区对脑缺血核心区的保护作用及其调控机制：围术期脑缺血防治[J].武汉大学学报（医学版）,2025,46(12):1645-1652. DOI： 10.14188/j.1671-8852.2025.0049.

WU Kefan,WANG Yuxuan,QIU Zhen,et al.Protective effects of remote brain regions on the ischemic core and their regulatory mechanisms: Perioperative prevention and treatment of cerebral ischemia[J].Medical Journal of Wuhan University,2025,46(12):1645-1652. DOI： 10.14188/j.1671-8852.2025.0049.

摘要

围术期脑组织缺血是常见的神经系统并发症，严重影响患者的预后。脑血管病变和血流动力学改变是导致脑组织灌注不足的主要病因，这一过程会引发持续的缺血状态，随着缺血时间的延长，神经细胞损伤逐渐加重，最终可能导致不可逆的神经功能丧失。近年来，研究者逐渐关注未缺血脑区对缺血核心区的保护作用，发现各脑区之间存在紧密的功能性和应激响应联系。当局部缺血发生时，未缺血脑区能迅速调动保护性机制，通过神经保护作用有效缓解缺血核心区的损伤。如何进一步增强未缺血脑区的保护效应，以改善患者围术期的短期恢复并促进长期康复，成为当前研究的重要方向。本文综述了未缺血脑区在缺血状态下的保护机制及其激活方式，分析了其在围术期临床脑缺血治疗中的潜在应用，并为未来相关研究提供理论支持。

Abstract

Perioperative cerebral ischemia is a common neurological complication that significantly affects patient prognosis. Cerebrovascular lesions and hemodynamic changes are the main causes of insufficient brain tissue perfusion

leading to a sustained ischemic state. As the ischemic time increases

neuronal damage gradually intensifies

potentially resulting in irreversible loss of neurological function. In recent years

researchers have increasingly focused on the protective effects of non⁃ischemic brain regions on the ischemic core. It has been found that there is a close functional and stress⁃response connection between brain regions. When local ischemia occurs

non⁃ischemic brain areas can quickly activate protective mechanisms and effectively alleviate damage in the ischemic core. How to further enhance the protective effects of non⁃ischemic brain regions to improve short⁃term recovery and promote long⁃term rehabilitation during the perioperative period has become an important direction of current research. This article reviews the protective mechanisms of non⁃ischemic brain regions under ischemic conditions and their activation methods

analyzes their potential applications in the clinical treatment of cerebral ischemia during the perioperative period

and provides theoretical support for future related research.

关键词

Keywords

references

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