预后营养指数对皮肌炎合并间质性肺病的预测价值

王玲; 王振发; 张佳瑞; 张固琴

doi:10.14188/j.1671-8852.2024.1026

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预后营养指数对皮肌炎合并间质性肺病的预测价值

临床医学研究 | 更新时间：2026-11-06

- 预后营养指数对皮肌炎合并间质性肺病的预测价值
- Predictive value of prognostic nutritional index in dermatomyositis complicated with interstitial lung disease
- 武汉大学学报（医学版） 2025年46卷第12期页码：1610-1615
- 作者机构：
  
  武汉大学中南医院呼吸与危重症学科湖北武汉 430071
- 作者简介：
  
  王玲，女，1999—，医学硕士生，主要从事呼吸疾病的研究，E⁃mail:wl773610@163.com
  张固琴，女，1982—，医学博士，主任医师，硕士生导师，主要从事呼吸疾病的研究，E⁃mail:zgqxiaoxiao@126.com
- 基金信息：
  
  中华国际医学交流基金会资助项目(Z⁃2017⁃24⁃2110)
- DOI：10.14188/j.1671-8852.2024.1026
  中图分类号： R563.1⁺3
- 收稿：2024-12-26，
  
  纸质出版：2025-12-25
- 稿件说明：
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王玲,王振发,张佳瑞等.预后营养指数对皮肌炎合并间质性肺病的预测价值[J].武汉大学学报（医学版）,2025,46(12):1610-1615.

WANG Ling,WANG Zhenfa,ZHANG Jiarui,et al.Predictive value of prognostic nutritional index in dermatomyositis complicated with interstitial lung disease[J].Medical Journal of Wuhan University,2025,46(12):1610-1615.
王玲,王振发,张佳瑞等.预后营养指数对皮肌炎合并间质性肺病的预测价值[J].武汉大学学报（医学版）,2025,46(12):1610-1615. DOI： 10.14188/j.1671-8852.2024.1026.

WANG Ling,WANG Zhenfa,ZHANG Jiarui,et al.Predictive value of prognostic nutritional index in dermatomyositis complicated with interstitial lung disease[J].Medical Journal of Wuhan University,2025,46(12):1610-1615. DOI： 10.14188/j.1671-8852.2024.1026.

摘要

目的

探讨预后营养指数（PNI）对皮肌炎（DM）患者合并间质性肺病（ILD）的预测价值。

方法

本研究纳入了2013年4月至2023年4月武汉大学中南医院初诊为DM患者共59例，其中36例合并ILD。回顾性分析PNI对DM患者合并ILD的预测价值，并探究了PNI与DM合并ILD患者血清学指标的相关性。

结果

ILD组PNI明显低于非ILD组（

=0.001）。Logistic回归表明，PNI是DM合并ILD的独立保护因素（

=0.792，95%

：0.641~0.978，

=0.030）。PNI（曲线下面积=0.753，

=0.001）对DM合并ILD具有良好的预测价值，截断值为38.68。在合并ILD患者中，PNI与C反应蛋白（CRP）、红细胞沉降率（ESR）、天冬氨酸氨基转移酶（AST）和铁蛋白等血清学标志物呈负相关（

0.05）。

结论

PNI对预测DM患者是否合并ILD及反映其肺部炎症反应程度方面具有一定临床价值。

Abstract

Objectives

To explore the predictive value of the prognostic nutritional index (PNI) for dermatomyositis (DM) patients with interstitial lung disease (ILD).

Methods

This study included 59 patients initially diagnosed with DM at Zhongnan Hospital of Wuhan University from April 2013 to April 2023

of whom 36 had concurrent ILD. We conducted a retrospective analysis to assess the predictive value of PNI in DM patients with ILD

and further analyzed the correlation between PNI and serological indicators.

Results

We discovered that PNI decreased in the ILD group (

=0.001). Logistic regression demonstrated that PNI was an independent protective factor (

=0.792

95%

: 0.641⁃0.978

=0.030). Also

PNI (area under the curve=0.753

=0.001) showed an effective diagnostic value for ILD. Additionally

there is a negative correlation between PNI and serological markers such as C⁃reactive protein (CRP)

erythrocyte sedimentation rate (ESR)

aspartate aminotransferase (AST) and ferritin in patients with ILD (

0.05).

Conclusion

PNI is clinically useful for predicting ILD occurrence in DM patients and for reflecting the degree of pulmonary inflammatory response.

关键词

Keywords

references

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