C反应蛋白结构活性与应答特征研究现状与展望

李正钧; 段文杰; 张迪; 张培蕾; 潘兹书

doi:10.14188/j.1671-8852.2024.0835

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C反应蛋白结构活性与应答特征研究现状与展望

综述 | 更新时间：2026-11-05

- C反应蛋白结构活性与应答特征研究现状与展望
- State of the art and prospects in the structure, activity, and response characteristics of C⁃reaction protein
- 武汉大学学报（医学版） 2025年46卷第10期页码：1370-1373
- 作者机构：
  
  1.郑州方欣生物科技有限责任公司河南郑州 451100
  2.河南杰瑞生物科技研究院有限公司河南郑州 451163
  3.武汉大学生命科学学院湖北武汉 430072
- 作者简介：
  
  李正钧，男，1973—，主要从事体外诊断产品研发和质量管理等工作，E⁃mail: 1018681184@qq.com
  潘兹书，男，1961—，理学博士，教授，博士生导师，主要从事感染与免疫和生物技术开发等研究，E⁃mail: zspan@whu.edu.cn
- 基金信息：
  
  国家自然科学基金资助项目(92374108)
- DOI：10.14188/j.1671-8852.2024.0835
  中图分类号： R446.1
- 收稿：2024-10-31，
  
  纸质出版：2025-10-25
- 稿件说明：
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李正钧,段文杰,张迪等.C反应蛋白结构活性与应答特征研究现状与展望[J].武汉大学学报（医学版）,2025,46(10):1370-1373.

LI Zhengjun,DUAN Wenjie,ZHANG Di,et al.State of the art and prospects in the structure, activity, and response characteristics of C⁃reaction protein[J].Medical Journal of Wuhan University,2025,46(10):1370-1373.
李正钧,段文杰,张迪等.C反应蛋白结构活性与应答特征研究现状与展望[J].武汉大学学报（医学版）,2025,46(10):1370-1373. DOI： 10.14188/j.1671-8852.2024.0835.

LI Zhengjun,DUAN Wenjie,ZHANG Di,et al.State of the art and prospects in the structure, activity, and response characteristics of C⁃reaction protein[J].Medical Journal of Wuhan University,2025,46(10):1370-1373. DOI： 10.14188/j.1671-8852.2024.0835.

摘要

C反应蛋白（CRP）是一种主要由肝脏合成的多功能蛋白质，与炎症反应相关的组织损伤事件会引起CRP血液浓度迅速变化。作为机体病理生理反应的重要生物标志物，CRP水平变化与人体健康状况密切相关。血液CRP浓度测定已在疾病临床诊断中广泛应用。本文综述了CRP结构、活性及应答动力学特征，并讨论了高敏C反应蛋白及其在预测心血管疾病等发病风险及预后评估中的意义。

Abstract

C⁃reactive protein (CRP) is a multifunctional protein primarily synthesized by the liver

blood CRP levels change rapidly and significantly in response to tissue⁃damaging events associated with inflammation. As a biomarker of pathophysiological response

the CRP levels are closely related to human health status and have been widely utilized in clinical diagnosis of diseases. This review will primarily focus on our current understanding of the structure

activity of CRP

as well as the kinetics of its response. In addition

the characterization of high⁃sensitivity CRP (hs⁃CRP) and its clinical significance in predicting the risk of cardiovascular diseases and in prognostic assessment are discussed.

关键词

Keywords

references

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