敏感抗生素联合普朗特敷料治疗感染性创面的临床疗效分析

王欣; 柳昌焕; 周敏; 方雪; 张旺; 王维兴; 杨夏晴

doi:10.14188/j.1671-8852.2024.0694

您当前的位置：

首页 >

文章列表页 >

敏感抗生素联合普朗特敷料治疗感染性创面的临床疗效分析

临床医学研究 | 更新时间：2026-11-05

- 敏感抗生素联合普朗特敷料治疗感染性创面的临床疗效分析
- Clinical efficacy analysis of sensitive antibiotics combined with Polyhexanide dressing in the treatment of infectious wounds
- 武汉大学学报（医学版） 2025年46卷第9期页码：1179-1184
- 作者机构：
  
  1.武汉大学中南医院创伤与显微骨科湖北武汉 430071
  2.巴东县人民医院湖北恩施 444300
  3.武汉大学中南医院老年髋部骨折诊疗中心湖北武汉 430071
- 作者简介：
  
  王欣，男，1969—，医学博士，主任医师，主要从事四肢骨折修复与重建研究，E‑mail：wangxinznyy@whu.edu.cn
  杨夏晴，男，1989—，医学博士，主治医师，主要从事四肢骨折及软组织显微修复与重建研究，E‑mail：2018103030020@whu.edu.cn
- 基金信息：
  
  湖北省自然科学基金计划项目(2024AFC004);湖北省骨外科学科能力建设项目(YYXKNL2022009)
- DOI：10.14188/j.1671-8852.2024.0694
  中图分类号： R63
- 收稿：2024-09-11，
  
  纸质出版：2025-09-26
- 稿件说明：
移动端阅览
王欣,柳昌焕,周敏等.敏感抗生素联合普朗特敷料治疗感染性创面的临床疗效分析[J].武汉大学学报（医学版）,2025,46(09):1179-1184.

WANG Xin,LIU Changhuan,ZHOU Min,et al.Clinical efficacy analysis of sensitive antibiotics combined with Polyhexanide dressing in the treatment of infectious wounds[J].Medical Journal of Wuhan University,2025,46(09):1179-1184.
王欣,柳昌焕,周敏等.敏感抗生素联合普朗特敷料治疗感染性创面的临床疗效分析[J].武汉大学学报（医学版）,2025,46(09):1179-1184. DOI： 10.14188/j.1671-8852.2024.0694.

WANG Xin,LIU Changhuan,ZHOU Min,et al.Clinical efficacy analysis of sensitive antibiotics combined with Polyhexanide dressing in the treatment of infectious wounds[J].Medical Journal of Wuhan University,2025,46(09):1179-1184. DOI： 10.14188/j.1671-8852.2024.0694.

摘要

目的

探讨敏感抗生素联合普朗特敷料治疗感染性创面的临床疗效。

方法

回顾性分析武汉大学中南医院创伤与显微骨科2016年1月至2020年1月期间收治的78例感染性创面患者资料。根据治疗方法的不同，将患者分为普朗特组和对照组。普朗特组39例，采用敏感抗生素联合普朗特液体伤口敷料或普朗特凝胶换药治疗；对照组39例，采用敏感抗生素联合常规换药治疗。评估两组患者创面细菌培养转阴时间、清创次数、Bates‑Jensen伤口评价工具(BWAT)和住院时间。

结果

术后随访6~12个月，平均随访（7.51±1.46）个月。普朗特组患者创面细菌培养转阴时间为（7.62±1.70） d，显著短于对照组患者（8.82±1.30） d(

0.05)；普朗特组患者的清创次数为2.00（2.00

3.00）次，显著低于对照组患者的清创次数4.00（3.00

4.00）次(

0.05)；普朗特组患者BWAT评分下降幅度（17.21±2.31）分，对照组患者BWAT评分下降幅度（12.15±1.71）分，普朗特组患者BWAT评分下降幅度显著大于对照组(

0.05)；普朗特组患者住院时间为（11.82±1.96） d，显著低于对照组患者的时间（17.15±2.35） d(

0.05)。

结论

敏感抗生素联合普朗特敷料治疗感染性创面效果良好，不仅有助于创面快速愈合，还可缩短创面细菌感染时间，减少清创次数，降低BWAT评分，减少住院天数，改善创面外观，具有较高的临床应用价值。

Abstract

Objective

To investigate the clinical efficacy of polyhexanide in the treatment of infectious wounds.

Methods

The data of 78 patients with infectious wounds admitted to Zhongnan Hospital of Wuhan University from January 2016 to January 2020 were retrospectively analyzed

and according to different treatment methods

the patients were divided into two groups. The polyhexanide group (39 cases) received sensitive antibiotics combined with polyhexanide liquid wound dressing or polyhexanide gel dressing change

and the control group (39 cases) received sensitive antibiotics combined with conventional dressing change. Time to negative bacterial culture conversion

debridement times

Bates‑Jensen Wound Assessment Tool (BWAT) and length of hospital stay were evaluated in both groups.

Results

The average follow‑up was (7.51±1.46) months for 6⁃12 months. The time for wound bacterial culture to turn negative in polyhexanide group was (7.62±1.70) d

which was significantly shorter than (8.82±1.30) d in control group (

0.05). The debridement frequency of polyhexanide group was 2.00 (2.00

3.00) times

significantly lower than the 4.00 (3.00

4.00) times in the control group (

0.05). The decrease of BWAT score in polyhexanide group was （17.21±2.31） points

and that in control group was （12.15±1.71） points

with a statistically significant difference (

0.05). The hospitalization time of polyhexanide group was (11.82±1.96) d

which was significantly lower than (17.15±2.35) d of control group (

0.05).

Conclusion

Polyhexanide is effective in the treatment of infected wounds

as it can not only help the wound heal quickly

but also shorten the time of bacterial infection and hospitalization stay

reduce the debridement times and BWAT scores

and optimize wound presentation.

关键词

Keywords

references

刘毅 . 提高感染性创面诊治水平需要关注的几个问题 [J ] . 中华烧伤与创面修复杂志 , 2024 , 40 ( 2 ): 119 ‑ 124 .

LIU Y . Several issues that need attention to improve the diagnosis and treatment level of infectious wounds [J ] . Chinese Journal of Burn and Wound , 2024 , 40 ( 2 ): 119 ‑ 124 .

于家傲 , 高欣欣 . 细菌生物膜与慢性创面感染 [J ] . 中华烧伤杂志 , 2019 , 35 ( 12 ): 842 ‑ 847 .

YU J A , GAO X X . Bacterial biofilm and chronic wound infection [J ] . Chin J Burns , 2019 , 35 ( 12 ): 842 ‑ 847 .

魏敏 , 金莉 , 季怡虹 .“ 伤口感染临床实践: 最佳实践原则(2022)”解读 [J ] . 创伤外科杂志 , 2023 , 25 ( 6 ): 408 ‑ 412 .

WEI M , JIN L , JI Y H . Interpretation of Wound Infection in Clinical Practice: Best Practice Principles (2022) [J ] . J Trauma Surg , 2023 , 25 ( 6 ): 408 ‑ 412 .

ZHOU M , LIU Y P , FANG X , et al . The effectiveness of polyhexanide in treating wound infections due to methicillin‑resistant Staphylococcus aureus : A prospective analysis [J ] . Infect Drug Resist , 2024 , 17 : 1927 ‑ 1935 .

YANG L T , WANG W J , HUANG W T , et al . Photo‑responsive ascorbic acid‑modified Ag(2)S‑ZnS heteronanostructure dropping pH to trigger synergistic antibacterial and Bohr effects for accelerating infected wound healing [J ] . ACS Appl Mater Interfaces , 2024 , 16 ( 9 ): 1 2018‑ 12032 .

LI X Y , JING X , YU Z Q , et al . Diverse antibacterial treatments beyond antibiotics for diabetic foot ulcer therapy [J ] . Adv Healthc Mater , 2023 , 12 ( 23 ): e2300375 .

WU Y F , LI J G , ZHU L W , et al . Photosensitive AIEgens sensitize bacteria to oxidative damage and modulate the inflammatory responses of macrophages to salvage the photodynamic therapy against MRSA [J ] . Biomaterials , 2024 , 309 : 122583 .

BELLINGERI A , FALCIANI F , TRASPEDINI P , et al . Effect of a wound cleansing solution on wound bed preparation and inflammation in chronic wounds: A single‑blind RCT [J ] . J Wound Care , 2016 , 25 ( 3 ): 160 , 162 ‑ 166 , 168 .

LI T T , REN X B , LUO X L , et al . A foundation model identifies broad‑spectrum antimicrobial peptides against drug‑resistant bacterial infection [J ] . Nat Commun , 2024 , 15 ( 1 ): 7538 .

GUPTA S , SRIVASTAVA A , MALHOTRA R , et al . Wound assessment using Bates Jensen wound assessment tool in acute musculoskeletal injury following low‑cost wall‑mounted negative‑pressure wound therapy application [J ] . Indian J Orthop , 2023 , 57 ( 6 ): 948 ‑ 956 .

HURLOW J , BOWLER P G . Acute and chronic wound infections: Microbiological, immunological, clinical and therapeutic distinctions [J ] . J Wound Care , 2022 , 31 ( 5 ): 436 ‑ 445 .

BARRETO R , BARROIS B , LAMBERT J , et al . Addressing the challenges in antisepsis: Focus on povidone iodine [J ] . Int J Antimicrob Agents , 2020 , 56 ( 3 ): 106064 .

RICCI E . The management of chronic ulcers with an acidoxidising solution [J ] . J Wound Care , 2016 , 25 ( 8 ): 443 ‑ 450 .

WONGKIETKACHORN A , SURAKUNPRAPHA P , WITTAYAPAIROCH J , et al . The use of hypochlorous acid lavage to treat infected cavity wounds [J ] . Plast Reconstr Surg Glob Open , 2020 , 8 ( 1 ): e2604 .

SANDOZ H . An overview of the prevention and management of wound infection [J ] . Nurs Stand , 2022 , 37 ( 10 ): 75 ‑ 82 .

刘文雅 , 钱文慧 , 苏华 , 等 . 复方愈创洗液对细菌性感染创面修复的影响研究 [J ] . 中国药师 , 2019 , 22 ( 7 ): 1246 ‑ 1249 .

LIU W Y , QIAN W H , SU H , et al . Effect of compound Yuchuang Lotion on wound healing in mice with bacterial infection [J ] . China Pharm , 2019 , 22 ( 7 ): 1246 ‑ 1249 .

OLUWOLE D O , COLEMAN L , BUCHANAN W , et al . Antibiotics‑free compounds for chronic wound healing [J ] . Pharmaceutics , 2022 , 14 ( 5 ): 1021 .

LIVINGSTONE J P , HASEGAWA I G , MURRAY P . Utilizing negative pressure wound therapy with instillation and dwell time for extensive necrotizing fasciitis of the lower extremity: A case report [J ] . Cureus , 2018 , 10 ( 10 ): e3483 .

王晨 , 李廷 , 罗鹏飞 , 等 . 液体伤口敷料在治疗慢性溃疡创面中的临床应用 [J ] . 中国修复重建外科杂志 , 2016 , 30 ( 12 ): 1507 ‑ 1511 .

WANG C , LI T , LUO P F , et al . Clinical application of liquid wound dressing in treatment of chronic ulcer wounds [J ] . Chin J Reparative Reconstr Surg , 2016 , 30 ( 12 ): 1507 ‑ 1511 .

SOWLATI‑HASHJIN S , CARBONE P , KARTTUNEN M . Insights into the polyhexamethylene biguanide (PHMB) mechanism of action on bacterial membrane and DNA: A molecular dynamics study [J ] . J Phys Chem B , 2020 , 124 ( 22 ): 4487 ‑ 4497 .

杜玉青 , 连晓彤 , 李创 , 等 . 液体伤口敷料联合负压滴灌治疗糖尿病足感染的临床效果观察 [J ] . 中国中西医结合外科杂志 , 2021 , 27 ( 1 ): 52 ‑ 57 .

DU Y Q , LIAN X T , LI C , et al . Clinical observation of liquid wound dressing combined with negative pressure drip irrigation in the treatment of diabetic foot infection [J ] . Chin J Surg Integr Tradit West Med , 2021 , 27 ( 1 ): 52 ‑ 57 .

王欣 , 谢哲 , 李宗焕 , 等 . 外固定支架结合普朗特治疗合并多重耐药菌感染的开放性骨折的疗效分析 [J ] . 中华创伤骨科杂志 , 2022 , 24 ( 6 ): 503 ‑ 509 .

WANG X , XIE Z , LI Z H , et al . External fixation combined with Prontosan management for open fractures complicated with multidrug‑resistant bacterial infection [J ] . Chin J Orthop Trauma , 2022 , 24 ( 6 ): 503 ‑ 509 .

CIPRANDI G , RAMSAY S , BUDKEVICH L , et al . A retrospective systematic data review on the use of a polihexanide‑containing product on burns in children [J ] . J Tissue Viability , 2018 , 27 ( 4 ): 244 ‑ 248 .

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

糖尿病患者的感染易感性及其生理学机制

448例儿童烧伤患者病原菌分布调查及抗菌药物敏感性分析

感染对慢性阻塞性肺疾病系统性炎症反应的影响

儿童急性荨麻疹发病与隐匿性链球菌感染的相关性

静脉血栓栓塞症预防健康教育的研究进展