支架植入术对症状性颅内外大动脉重度狭窄患者认知功能及生存质量的影响

李强敏; 杨黎辉; 郭耀强; 周艳丽; 石见

doi:10.14188/j.1671-8852.2024.0551

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支架植入术对症状性颅内外大动脉重度狭窄患者认知功能及生存质量的影响

临床医学研究 | 更新时间：2026-11-05

- 支架植入术对症状性颅内外大动脉重度狭窄患者认知功能及生存质量的影响
- Effect of stent implantation on cognitive function and quality of life in patients with symptomatic severe intracranial and extracranial arterial stenosis
- 武汉大学学报（医学版） 2025年46卷第11期页码：1475-1480
- 作者机构：
  
  1.郑州人民医院神经内科河南郑州 450002
  2.郑州卫生健康职业学院河南郑州 450100
  3.河南科技大学第一附属医院神经内科河南洛阳 471099
- 作者简介：
  
  李强敏，男，1978—，医学硕士，副主任医师，主要从事脑血管介入治疗研究，E⁃mail:laige95213@163.com
  周艳丽，女，1973—，医学硕士，主任医师，主要从事脑血管病研究，E⁃mail:Y204003@126.com
- 基金信息：
  
  2020年河南省医学科技攻关计划联合共建项目(LHGJ20200575)
- DOI：10.14188/j.1671-8852.2024.0551
  中图分类号： R743
- 纸质出版：2025-11-25
- 稿件说明：
移动端阅览
李强敏,杨黎辉,郭耀强等.支架植入术对症状性颅内外大动脉重度狭窄患者认知功能及生存质量的影响[J].武汉大学学报（医学版）,2025,46(11):1475-1480.

LI Qiangmin,YANG Lihui,GUO Yaoqiang,et al.Effect of stent implantation on cognitive function and quality of life in patients with symptomatic severe intracranial and extracranial arterial stenosis[J].Medical Journal of Wuhan University,2025,46(11):1475-1480.
李强敏,杨黎辉,郭耀强等.支架植入术对症状性颅内外大动脉重度狭窄患者认知功能及生存质量的影响[J].武汉大学学报（医学版）,2025,46(11):1475-1480. DOI： 10.14188/j.1671-8852.2024.0551.

LI Qiangmin,YANG Lihui,GUO Yaoqiang,et al.Effect of stent implantation on cognitive function and quality of life in patients with symptomatic severe intracranial and extracranial arterial stenosis[J].Medical Journal of Wuhan University,2025,46(11):1475-1480. DOI： 10.14188/j.1671-8852.2024.0551.

摘要

目的

探讨支架植入术（PTAS）对症状性颅内外大动脉重度狭窄患者认知功能及生存质量的影响。

方法

选取2021年1月—2023年12月郑州人民医院收治的100例症状性颅内外大动脉重度狭

窄患者，按照治疗方案将其分为常规组（

=49）和支架组（

=51）。常规组给予常规药物治疗，支架组在常规组基础上给予PTAS治疗。比较两组认知功能[简易精神状态评价量（MMSE）、蒙特利尔认知评估量表（MoCA）

]

、神经功能[美国国立卫生研究院卒中量表（NIHSS）

]

、血管狭窄程度、临床疗效、并发症、预后[改良Rankin量表（mRS）

]

及生存质量[简易生活质量量表（QOL⁃BREF）

]

。

结果

治疗后，两组MMSE、MoCA评分均升高，且支架组更高（

0.05）；治疗后常规组的血管狭窄程度较治疗前的差异无统计学意义（

0.05）；两组NIHSS评分均降低，且支架组NIHSS评分、血管狭窄程度更低（

0.05）；支架组治疗总有效率高于常规组（

0.05）；支架组并发症总发生率低于常规组（

0.05）；治疗后，两组mRS评分均降低、QOL⁃BREF评分均升高，且支架组mRS评分更低、QOL⁃BREF评分更高（

0.05）。

结论

PTAS能有效治疗症状性颅内外大动脉重度狭窄，改善患者认知功能，减轻神经功能缺损，提高患者预后及生存质量，安全性良好。

Abstract

Objective

To investigate the effect of percutaneous transluminal angioplasty and stenting (PTAS) on cognitive function and quality of life in patients with severe intracranial and extracranial arterial stenosis.

Methods

From January 2021 to December 2023

100 patients with symptomatic severe intracranial and extracranial arterial stenosis were enrolled and divided into the routine group (

=49) and stent group (

=51) according to different treatment schemes. The routine group was given routine drug treatment

and the stent group was given PTAS therapy based on the routine group. Cognitive function (mini mental state assessment (MMSE)

Montreal cognitive assessment scale (MoCA))

neurological function (National Institutes of Health Stroke Scale (NIHSS))

degree of vascular stenosis

clinical efficacy

complications

prognosis (modified rankin scale (mRS)) and quality of life (quality of life brief scale (QOL⁃BREF)) were compared between the two groups.

Results

After treatment

the scores of MMSE and MoCA in both groups increased

especially in the stent group (

0.05). There were no statistical changes in the degree

of vascular stenosis in the routine group after treatment (

0.05). The NIHSS scores in both groups decreased after treament

and the changes in NIHSS scores and the degrees of vascular stenosis in the stent group were more significant (

0.05). The total effective rate of the stent group was higher (

0.05). The total incidence of complications in the stent group was lower (

0.05). After treatment

the mRS score decreased and the QOL⁃BREF score increased in both groups

and the mRS score was lower and the QOL⁃BREF score was higher in the stent group (

0.05).

Conclusion

PTAS can improve patients' cognitive function and reduce neurological deficits effectively in symptomatic severe intracranial and extracranial arterial stenosis patients. It can also improve the patients' prognosis and quality of life with good safety.

关键词

Keywords

references

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