抗凝治疗对急性呼吸窘迫综合征疗效及预后影响的Meta分析

向婷; 邓医宇

doi:10.14188/j.1671-8852.2024.0502

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抗凝治疗对急性呼吸窘迫综合征疗效及预后影响的Meta分析

急性呼吸窘迫综合征专题研究 | 更新时间：2026-11-05

- 抗凝治疗对急性呼吸窘迫综合征疗效及预后影响的Meta分析
- Meta⁃analysis of the therapeutic effect and prognostic impact of anticoagulant therapy on acute respiratory distress syndrome
- 武汉大学学报（医学版） 2025年46卷第2期页码：205-211
- 作者机构：
  
  南方医科大学附属广东省人民医院/广东省医学科学院重症医学科广东广州 510080
- 作者简介：
  
  向婷，女，1999—，医学硕士生，主要从事ARDS临床及机制研究，E‑mail：13074256453@163.com
  邓医宇，男，1972—，主任医师，主要从事脓毒症脑病与ARDS临床及机制研究，E‑mail：yiyudeng666@163.com
- 基金信息：
  
  国家重点研发计划项目(2021YFC2501800)
- DOI：10.14188/j.1671-8852.2024.0502
  中图分类号： R459.4
- 收稿：2024-07-05，
  
  纸质出版：2025-02-25
- 稿件说明：
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向婷,邓医宇.抗凝治疗对急性呼吸窘迫综合征疗效及预后影响的Meta分析[J].武汉大学学报（医学版）,2025,46(02):205-211.

XIANG Ting,DENG Yiyu.Meta⁃analysis of the therapeutic effect and prognostic impact of anticoagulant therapy on acute respiratory distress syndrome[J].Medical Journal of Wuhan University,2025,46(02):205-211.
向婷,邓医宇.抗凝治疗对急性呼吸窘迫综合征疗效及预后影响的Meta分析[J].武汉大学学报（医学版）,2025,46(02):205-211. DOI： 10.14188/j.1671-8852.2024.0502.

XIANG Ting,DENG Yiyu.Meta⁃analysis of the therapeutic effect and prognostic impact of anticoagulant therapy on acute respiratory distress syndrome[J].Medical Journal of Wuhan University,2025,46(02):205-211. DOI： 10.14188/j.1671-8852.2024.0502.

摘要

目的

系统评价急性呼吸窘迫综合征(ARDS)患者抗凝治疗的疗效及预后。

方法

检索PubMed、Cochrane Library、Embase、Web of Science、中国知网数据库，检索时间为各数据库建库起至2024年6月，纳入肝素/低分子肝素对比安慰剂或其他药物治疗ARDS的随机对照试验（RCT），采用Revman 5.1统计软件进行Meta分析。

结果

共纳入7项RCT 513例ARDS患者。与对照组相比，肝素/低分子肝素治疗组的患者氧合指数显著改善（

=10.46，

0.01）；ICU住院天数显著缩短（

=5.58，

0.01）；机械通气时间缩短（

=5.54，

0.01）；APTT时间无显著差异（

=1.21

=0.23）。

结论

肝素/低分子肝素抗凝治疗可有效改善成人ARDS患者的氧合指数，缩短ICU住院时间、机械通气天数。

Abstract

Objective

To systematically evaluate the efficacy and prognosis of anticoagulant therapy in patients with acute respiratory distress syndrome (ARDS).

Methods

We searched PubMed

Cochrane Library

Embase

Web of Science

and China National Knowledge Infrastructure databases from the inception of each database to June 2024

for randomized controlled trials (RCTs) comparing heparin/low molecular weight heparin to placebo or other drug treatments for ARDS. Meta‑analysis was conducted using Revman 5.1 statistical software.

Results

A total of 7 RCTs involving 513 ARDS patients were included. Compared with the control group

the heparin/low molecular weight heparin treatment group showed significant improvement in oxygenation index (

=10.46

0.01)

a significant reduction in ICU stays (

=5.58

0.01)

and a shorter duration of mechanical ventilation (

=5.54

0.01). However

there was no significant difference in APTT time (

=1.21

=0.23).

Conclusion

Anticoagulant therapy with heparin or low molecular weight heparin can effectively improve the oxygenation index in adult ARDS patients

shorten ICU stays

and reduce the duration of mechanical ventilation.

关键词

Keywords

references

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