南方医科大学附属广东省人民医院/广东省医学科学院重症医学科 广东 广州 510000
林思敏,女,1998—,医学硕士,主要从事ARDS研究,E⁃mail:linsmlin@163.com
邓医宇,男,1972—,医学博士,主任医师,主要从事脓毒症脑病与ARDS临床及机制研究,E⁃mail:yiyudeng666@163.com
收稿:2024-07-04,
纸质出版:2025-02-25
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林思敏,邓医宇.急性呼吸窘迫综合征凝血功能障碍相关诊断和预后预测标志物研究进展[J].武汉大学学报(医学版),2025,46(02):220-225.
LIN Simin,DENG Yiyu.Advances in the biomarkers of coagulation dysfunction on the diagnosis and prognosis of acute respiratory distress syndrome[J].Medical Journal of Wuhan University,2025,46(02):220-225.
林思敏,邓医宇.急性呼吸窘迫综合征凝血功能障碍相关诊断和预后预测标志物研究进展[J].武汉大学学报(医学版),2025,46(02):220-225. DOI: 10.14188/j.1671-8852.2024.0497.
LIN Simin,DENG Yiyu.Advances in the biomarkers of coagulation dysfunction on the diagnosis and prognosis of acute respiratory distress syndrome[J].Medical Journal of Wuhan University,2025,46(02):220-225. DOI: 10.14188/j.1671-8852.2024.0497.
急性呼吸窘迫综合征是弥漫性肺部炎症和水肿导致急性呼吸衰竭的临床综合征,其典型特征是肺泡⁃毛细血管屏障两层损伤,会导致促炎、促凝血途径激活,微血管血栓形成。血管生成素⁃2、D⁃二聚体、可溶性血栓调节蛋白等凝血相关生物标志物有助于诊断急性呼吸窘迫综合征和预测预后。本文综述了急性呼吸窘迫综合征凝血途径相关诊断和预后预测生物标志物。
Acute respiratory distress syndrome (ARDS) is a clinical syndrome of acute respiratory failure caused by diffuse pulmonary inflammation and edema. Typical pathological features include injury to the alveolar⁃capillary barrier
which triggers the activation of proinflammatory and procoagulant pathways. Coagulation⁃related biomarkers
including angiopoietin⁃2 and D⁃dimer
play significant roles in the diagnosis and prognosis prediction of ARDS. This article provides an overview of the research progress on these biomarkers.
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