不同表型的多囊卵巢综合征患者的生活质量及影响因素分析

程秋瑾; 杨红艳; 王卫兵

doi:10.14188/j.1671-8852.2024.0478

您当前的位置：

首页 >

文章列表页 >

不同表型的多囊卵巢综合征患者的生活质量及影响因素分析

临床医学研究 | 更新时间：2026-11-05

- 不同表型的多囊卵巢综合征患者的生活质量及影响因素分析
- Analysis of quality of life and influencing factors of patients with different phenotypes of polycystic ovary syndrome
- 武汉大学学报（医学版） 2025年46卷第6期页码：781-786
- 作者机构：
  
  潜江市中心医院妇科湖北潜江 433199
- 作者简介：
  
  程秋瑾，女，1983—，主治医师，主要研究妇科常见疾病，E⁃mail：h7305568@163.com
- 基金信息：
  
  湖北省卫生健康委科研项目(WJ2020F159)
- DOI：10.14188/j.1671-8852.2024.0478
  中图分类号： R587.1
- 收稿：2024-06-27，
  
  纸质出版：2025-06-25
- 稿件说明：
移动端阅览
程秋瑾,杨红艳,王卫兵.不同表型的多囊卵巢综合征患者的生活质量及影响因素分析[J].武汉大学学报（医学版）,2025,46(06):781-786.

CHENG Qiujin,YANG Hongyan,WANG Weibing.Analysis of quality of life and influencing factors of patients with different phenotypes of polycystic ovary syndrome[J].Medical Journal of Wuhan University,2025,46(06):781-786.
程秋瑾,杨红艳,王卫兵.不同表型的多囊卵巢综合征患者的生活质量及影响因素分析[J].武汉大学学报（医学版）,2025,46(06):781-786. DOI： 10.14188/j.1671-8852.2024.0478.

CHENG Qiujin,YANG Hongyan,WANG Weibing.Analysis of quality of life and influencing factors of patients with different phenotypes of polycystic ovary syndrome[J].Medical Journal of Wuhan University,2025,46(06):781-786. DOI： 10.14188/j.1671-8852.2024.0478.

摘要

目的

评估不同多囊卵巢综合征（PCOS）患者的生活质量（QoL）并分析其影响因素。

方法

采用横断面设计，将2018年1月1日—2019年12月31日88例首次诊断为PCOS并在潜江市中心医院妇产科建立记录的汉族女性纳入研究。参照鹿特丹标准进行PCOS分型，将所有患者分为26例表型A、12例表型B、22例表型C、28例表型D。使用多囊卵巢综合征健康相关生活质量问卷修正版（MPCOSQ）调查研究对象的QoL。

结果

人体测量指标中，不同PCOS表型研究人群的体质量存在显著差异（

0.05）。相对于表型C和表型D患者，具有表型A和B的女性表现出显著更高的胰岛素水平、胰岛素抵抗指数（HOMA⁃IR）和总睾酮（

0.05），而表型A和B之间没有观察到统计学差异。此外，4种PCOS表型的当前月经状态存在显著差异（

=0.036），表型A、B和D月经正常人数显著低于表型C（

0.05）。PCOS不同表型的MPCOSQ总分存在显著差异（

0.05）；在多毛症亚组中，表型A和B得分显著低于表型C和D（

0.05）。在痤疮亚组中，表型A、B和C得分显著低于表型D（

0.05）。在月经症状亚组中，表型A、B和D得分显著低于表型C（

0.05）。表型A和B中较低的QoL与体质量（

=-0.388、-0.627，

0.001），多毛症（

=-0.310、-0.271，

0.01）和月经异常（

=-0.284、-0.305，

0.01）显著关联。表型C、D中较低的QoL与体质量（

=-0.437、-0.295，

0.01）和月经异常（

=-0.337、-0.387，

0.001）显著关联。

结论

表型A、B的QoL评分显著低于表型C、D。科学减肥，针对表型A和B结合抗雄激素给药并针对表型C和D提高生育能力可改善PCOS患者的生活质量。

Abstract

Objective

To evaluate the quality of life (QoL) characteristics in women with distinct polycystic ovary syndrome (PCOS) phenotypes and explore factors related to reduced QoL.

Methods

A cross⁃sectional design was conducted. A total of 88 Han females were first diagnosed with PCOS and established a record at the Department of Obstetrics and Gynecology of Qianjiang Central Hospital from January 1

2018

to December 31

2019. The patients were assigned into three grouops according to the Rotterdam criteria as: 26 cases of phenotype A

12 cases of phenotype B

22 cases of phenotype C

and 28 cases of phenotype D. The QoL of the subjects was investigated using the modified polycystic ovary syndrome health⁃related quality of life questionnaire (MPCOSQ).

Results

Among anthropometric parameters

there were significant differences in body weight among different PCOS phenotype study populations (

0.05). Relative to the phenotype C and D patients

women with phenotypes A and B exhibited significantly higher insulin levels

HOMA⁃IR

and total testosterone (

0.05). At the same time

no difference was observed between phenotypes A and B. In addition

there was a significant difference in current menstruation status among the four PCOS phenotypes (

=0.036)

and the normal number of phenotypes A

and D was significantly lower than that of phenotype C (

0.05). The MPCOSQ total scores of different phenotypes of PCOS were significantly different (

0.05); in the hirsutism subgroup

phenotypes A and B scored patients were significantly lower than those of phenotypes C and D (

0.05). In the acne subgroup

phenotypes A

and C patients scored significantly lower than phenotype D patients (

0.05). In the menstrual symptom subgroup

phenotypes A

and D patients scored significantly lower than phenotype C patients (

0.05). Poor QoL in phenotypes A and B patients was associated with body weight (

=-0.388

-0.627

0.001)

hirsutism (

=-0.310

-0.271

0.01) and menstrual abnormalities (

=-0.284

-0.305

0.01). Poor QoL in phenotypes C and D patients was significantly associated with body weight (

=-0.437

-0.295

0.01) and menstrual abnorma

lities (

=-0.337

-0.387

0.001).

Conclusion

The QoL scores of phenotypes A and B patients were significantly lower than those of phenotypes C and D. Interventions to improve QoL in PCOS patients are scientific weight loss and combined antiandrogen administration for phenotypes A and B

and enhancing fertility for phenotypes C and D.

关键词

Keywords

references

韩启新 , 徐洁颖 , 储维薇 , 等 . 雄激素与肠道菌群在多囊卵巢综合征中作用机制的研究进展 [J ] . 生理科学进展 , 2020 , 51 ( 1 ): 77 ‑ 81 .

HAN Q X , XU J Y , CHU W W , et al . Role of androgen and gastrointestinal microbiome in the polycystic ovary syndrome [J ] . Prog Physiol Sci , 2020 , 51 ( 1 ): 77 ‑ 81 .

寇丽辉 , 侯丽辉 , 马建 , 等 . 多囊卵巢综合征(痰湿证)合并胰岛素抵抗患者的临床特征分析 [J ] . 中华中医药杂志 , 2020 , 35 ( 4 ): 2113 ‑ 2116 .

KOU L H , HOU L H , MA J , et al . Clinical characteristics of patients with polycystic ovary syndrome (phlegm‑dampness syndrome) combined with insulin resistance [J ] . China J Tradit Chin Med Pharm , 2020 , 35 ( 4 ): 2113 ‑ 2116 .

乔杰 , 齐新宇 , 徐雅兰 , 等 . 关注影响女性健康的重要生殖内分泌疾病多囊卵巢综合征 [J ] . 中国实用妇科与产科杂志 , 2020 , 36 ( 1 ): 1 ‑ 9 .

QIAO J , QI X Y , XU Y L , et al . Pay attention to polycystic ovary syndrome, an important reproductive endocrine disease affecting women's health [J ] . Chin J Pract Gynecol Obstet , 2020 , 36 ( 1 ): 1 ‑ 9 .

钟兴明 , 顾恒 , 苗竹林 , 等 . PCOS不同临床表型的关系分析 [J ] . 中国妇幼健康研究 , 2020 , 31 ( 10 ): 1400 ‑ 1404 .

ZHONG X M , GU H , MIAO Z L , et al . The correlation research between the clinical features of PCOS [J ] . Chin J Woman Child Health Res , 2020 , 31 ( 10 ): 1400 ‑ 1404 .

RIESTENBERG C , JAGASIA A , MARKOVIC D , et al . Health care‑related economic burden of polycystic ovary syndrome in the United States: Pregnancy‑related and long‑term health consequences [J ] . J Clin Endocrinol Metab , 2022 , 107 ( 2 ): 575 ‑ 585 .

赵晓苗 , 杨亚波 , 韩杨 , 等 . 改良简化的Ferriman⁃Gallwey评分系统在中国女性多毛评价中的应用分析 [J ] . 中山大学学报(医学科学版) , 2017 , 38 ( 5 ): 699 ⁃ 704 .

ZHAO X M , YANG Y B , HAN Y , et al . Simplified analysis of modified Ferriman⁃Gallwey scoring system in evaluation of Chinese women: A prospective follow⁃up study in new terminal hair among pregnant women [J ] . J Sun Yat Sen Univ Med Sci , 2017 , 38 ( 5 ): 699 ⁃ 704 .

中国痤疮治疗指南专家组 . 中国痤疮治疗指南(2019修订版) [J ] . 临床皮肤科杂志 , 2019 , 48 ( 9 ): 583 ‑ 588 .

China Acne Treatment Guidelines Expert Group . Guideline for diagnosis and treatment of acne(the 2019 revised edition) [J ] . China Ind Econ , 2019 , 48 ( 9 ): 583 ‑ 588 .

DAI H , ALSALHE T A , CHALGHAF N , et al . The global burden of disease attributable to high body mass index in 195 countries and territories, 1990‑2017: An analysis of the Global Burden of Disease Study [J ] . PLoS Med , 2020 , 17 ( 7 ): e1003198 .

NI C M , HUANG W L , JIANG Y M , et al . Improving the accuracy and efficacy of diagnosing polycystic ovary syndrome by integrating metabolomics with clinical characteristics: Study protocol for a randomized controlled trial [J ] . Trials , 2020 , 21 ( 1 ): 169 .

LUO Y Y , XU X L , LI X B . Psychometric properties of the Chinese version of the modified polycystic ovary syndrome health‑related quality‑of‑life questionnaire [J ] . Health Qual Life Outcomes , 2020 , 18 ( 1 ): 131 .

BERNI T R , MORGAN C L , BERNI E R , et al . Polycystic ovary syndrome is associated with adverse mental health and neurodevelopmental outcomes [J ] . J Clin Endocrinol Metab , 2018 , 103 ( 6 ): 2116 ‑ 2125 .

DE FREITAS FONSECA M , ARAGAO L C , SESSA F V , et al . Interrelationships among endometriosis‑related pain symptoms and their effects on health‑related quality of life: A sectional observational study [J ] . Obstet Gynecol Sci , 2018 , 61 ( 5 ): 605 ‑ 614 .

周玲 , 俞超芹 , 翟东霞 , 等 . 不同体质量指数多囊卵巢综合征患者临床及内分泌特征的对比观察 [J ] . 中华中医药杂志 , 2020 , 35 ( 6 ): 3240 ‑ 3242 .

ZHOU L , YU C Q , ZHAI D X , et al . Comparative observation of clinical and endocrine characteristics of patients with polycystic ovary syndrome with different body mass indexes [J ] . China J Tradit Chin Med Pharm , 2020 , 35 ( 6 ): 3240 ‑ 3242 .

王东旭 , 石文婧 , 徐樱溪 , 等 . 肥胖多囊卵巢综合征患者转氨酶升高的影响因素研究 [J ] . 中国全科医学 , 2022 , 25 ( 3 ): 320 ‑ 324 .

WANG D X , SHI W J , XU Y X , et al . Associated factors of elevated transaminase in obese patients with polycystic ovary syndrome [J ] . Chin Gen Pract , 2022 , 25 ( 3 ): 320 ‑ 324 .

SÁNCHEZ‑FERRER M L , ADOAMNEI E , PRIETO‑SÁNCHEZ M T , et al . Health‑related quality of life in women with polycystic ovary syndrome attending to a tertiary hospital in Southeastern Spain: A case‑control study [J ] . Health Qual Life Outcomes , 2020 , 18 ( 1 ): 232 .

KRENTOWSKA A , KOWALSKA I . Metabolic syndrome and its components in different phenotypes of polycystic ovary syndrome [J ] . Diabetes Metab Res Rev , 2022 , 38 ( 1 ): e3464 .

KAZEMI M , MCBREAIRTY L E , ZELLO G A , et al . A pulse‑based diet and the Therapeutic Lifestyle Changes diet in combination with health counseling and exercise improve health‑related quality of life in women with polycystic ovary syndrome: Secondary analysis of a randomized controlled trial [J ] . J Psychosom Obstet Gynaecol , 2020 , 41 ( 2 ): 144 ‑ 153 .

COONEY L G , MILMAN L W , HANTSOO L , et al . Cognitive‑behavioral therapy improves weight loss and quality of life in women with polycystic ovary syndrome: A pilot randomized clinical trial [J ] . Fertil Steril , 2018 , 110 ( 1 ): 161 ‑ 171.e1 .

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

成人ICU患者出院后疼痛情况与生活质量的纵向研究

牙髓炎患者根管治疗术后血清CCL11、CX3CR1水平与患者疼痛评分及生活质量的关系

照顾负担对重性精神疾病患者家庭照顾者生活质量的影响：家庭复原力和压力知觉的链式中介模型

正念减压疗法对门诊心理性勃起功能障碍患者焦虑及生活质量的影响

人参皂苷防脱精华治疗雄激素性秃发的临床有效性和安全性研究