铁死亡在视网膜疾病中的研究进展

张丹蕾; 任和; 陈震

doi:10.14188/j.1671-8852.2024.0368

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铁死亡在视网膜疾病中的研究进展

综述 | 更新时间：2026-11-06

- 铁死亡在视网膜疾病中的研究进展
- Research progress on ferroptosis in retinal diseases
- 武汉大学学报（医学版） 2025年46卷第12期页码：1661-1668
- 作者机构：
  
  武汉大学人民医院眼科中心湖北武汉 430060
- 作者简介：
  
  张丹蕾，女，1999—，医学硕士生，主要从事玻璃体视网膜疾病研究， E⁃mail: danlei_zhang@163.com
  陈震，男，1976—，医学博士，主任医师，硕士生导师，主要从事玻璃体视网膜疾病研究，E⁃mail: hchenzhen@163.com
- 基金信息：
- DOI：10.14188/j.1671-8852.2024.0368
  中图分类号： R77
- 收稿：2024-05-14，
  
  纸质出版：2025-12-25
- 稿件说明：
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张丹蕾,任和,陈震.铁死亡在视网膜疾病中的研究进展[J].武汉大学学报（医学版）,2025,46(12):1661-1668.

ZHANG Danlei,REN He,CHEN Zhen.Research progress on ferroptosis in retinal diseases[J].Medical Journal of Wuhan University,2025,46(12):1661-1668.
张丹蕾,任和,陈震.铁死亡在视网膜疾病中的研究进展[J].武汉大学学报（医学版）,2025,46(12):1661-1668. DOI： 10.14188/j.1671-8852.2024.0368.

ZHANG Danlei,REN He,CHEN Zhen.Research progress on ferroptosis in retinal diseases[J].Medical Journal of Wuhan University,2025,46(12):1661-1668. DOI： 10.14188/j.1671-8852.2024.0368.

摘要

铁死亡（Ferroptosis）是近期新发现的一种细胞调节性死亡（RCD），其特征为铁依赖性脂质过氧化物致命性积累。它在形态学和生化水平上与其他RCD明显不同。近期的报道表明，铁死亡与多种疾病有关，包括癌症、神经退行性病变、急性肾损伤等。铁死亡也被发现与眼部细胞有关，这会导致多种眼科疾病。在该综述中，概述了铁死亡的发生机制及其调控机制，并描述了其在视网膜疾病中的研究成果，包括年龄相关性黄斑变性、视网膜色素上皮变性、糖尿病视网膜病变、视网膜缺血再灌注等。

Abstract

Ferroptosis

a recently unveiled form of regulated cell death (RCD)

is characterized by a lethal

iron⁃dependent buildup of lipid peroxides. Distinguished by its unique morphological and biochemical features

ferroptosis has emerged as a potential contributor to various diseases

including cancer

neurodegenerative conditions

and acute kidney injury. Ferroptosis in ocular cells has also been found to lead to a variety of ocular diseases. In this review

we outline the mechanisms of ferroptosis and its regulation

and describe findings on ferroptosis in retinal diseases

including age⁃related macular degeneration

retinitis pigmentosa

diabetic retinopathy

and retinal ischemia⁃reperfusion injury.

关键词

Keywords

references

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