Drp1依赖性线粒体裂变在急性肺损伤/急性呼吸窘迫综合征中的研究进展

张小雨; 苏李; 陈国忠

doi:10.14188/j.1671-8852.2024.0142

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Drp1依赖性线粒体裂变在急性肺损伤/急性呼吸窘迫综合征中的研究进展

综述与Meta分析 | 更新时间：2026-11-05

- Drp1依赖性线粒体裂变在急性肺损伤/急性呼吸窘迫综合征中的研究进展
- Research progress on Drp1 dependent mitochondrial fission in acute lung injury/acute respiratory distress syndrome
- 武汉大学学报（医学版） 2025年46卷第3期页码：407-412
- 作者机构：
  
  武汉大学人民医院呼吸与危重症医学科湖北武汉 430060
- 作者简介：
  
  张小雨，女，1997—，医学硕士生，主要从事呼吸危重症研究，E‐mail：zhangxiaoyu@whu.edu.cn
  苏李，男，1997—，医学硕士生，主要从事呼吸危重症治疗研究，E‐mail：1198780917@qq.com
  陈国忠，男，1963—，医学硕士，主任医师，主要从事呼吸危重症治疗研究，E‐mail: guozhongch6389@163.com
- 基金信息：
  
  湖北省科技攻关项目(2020FCA017)
- DOI：10.14188/j.1671-8852.2024.0142
  中图分类号： R563.8
- 收稿：2024-03-01，
  
  纸质出版：2025-03-25
- 稿件说明：
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张小雨,苏李,陈国忠.Drp1依赖性线粒体裂变在急性肺损伤/急性呼吸窘迫综合征中的研究进展[J].武汉大学学报（医学版）,2025,46(03):407-412.

ZHANG Xiaoyu,SU Li,CHEN Guozhong.Research progress on Drp1 dependent mitochondrial fission in acute lung injury/acute respiratory distress syndrome[J].Medical Journal of Wuhan University,2025,46(03):407-412.
张小雨,苏李,陈国忠.Drp1依赖性线粒体裂变在急性肺损伤/急性呼吸窘迫综合征中的研究进展[J].武汉大学学报（医学版）,2025,46(03):407-412. DOI： 10.14188/j.1671-8852.2024.0142.

ZHANG Xiaoyu,SU Li,CHEN Guozhong.Research progress on Drp1 dependent mitochondrial fission in acute lung injury/acute respiratory distress syndrome[J].Medical Journal of Wuhan University,2025,46(03):407-412. DOI： 10.14188/j.1671-8852.2024.0142.

摘要

急性肺损伤（ALI）/急性呼吸窘迫综合征（ARDS）是临床常见的急性进行性肺部炎症反应性疾病。因其病因和发病机制错综复杂，目前尚无针对性的特效药。动力相关蛋白1(Drp1)是调节线粒体裂变的关键因子，参与调控ALI/ARDS的病理生理过程，同时Drp1抑制剂mdivi‑1能有效缓解ALI/ARDS的发生发展。本文就Drp1调控ALI/ARDS病理生理过程及机制展开综述，以期为Drp1靶向药物的临床应用提供依据和参考，并为后续研究Drp1调控ALI/ARDS提供方向。

Abstract

Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a common acute progressive inflammatory disease in clinical practice. Due to its complex etiology and pathogenesis

there is currently no targeted and effective treatment. Dynamin related protein 1 (Drp1) is a key factor in regulating mitochondrial fission and is involved in the pathogenesis of ALI/ARDS. Meanwhile

the Drp1 inhibitor mdivi‑1 can effectively alleviate the progression of ALI/ARDS. This article reviews the pathogenesis and mechanisms of Drp1 regulation in ALI/ARDS. It aims to provide a basis and reference for the clinical application of Drp1⁃targeted drugs and to guide future research on Drp1 regulation in ALI/ARDS.

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references

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