孟德尔随机化分析生活习惯与骨关节炎发病风险的因果关联

赵丹阳; 刘思怡; 陈海涛; 陈廖斌

doi:10.14188/j.1671-8852.2024.0102

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孟德尔随机化分析生活习惯与骨关节炎发病风险的因果关联

临床医学研究 | 更新时间：2026-11-05

- 孟德尔随机化分析生活习惯与骨关节炎发病风险的因果关联
- Mendelian randomization analysis of the relationship between lifestyle and the risk of osteoarthritis
- 武汉大学学报（医学版） 2025年46卷第3期页码：357-364
- 作者机构：
  
  武汉大学中南医院关节与运动医学科湖北武汉 430071
- 作者简介：
  
  赵丹阳，男，1996—，医学硕士生，主要从事骨关节炎疾病研究，E⁃mail:danyangzhao16@163.com
  刘思怡，男，1992—，医学博士生，主要从事骨关节炎疾病研究，E⁃mail:lsy__0123@163.com
  陈廖斌，男，1963—，医学博士，主任医师，教授，主要从事骨关节疾病研究，E⁃mail:lbchen@whu.edu.cn
- 基金信息：
  
  湖北省自然科学基金资助项目(2023AFB598)
- DOI：10.14188/j.1671-8852.2024.0102
  中图分类号： R684.3
- 收稿：2024-02-15，
  
  纸质出版：2025-03-25
- 稿件说明：
移动端阅览
赵丹阳,刘思怡,陈海涛等.孟德尔随机化分析生活习惯与骨关节炎发病风险的因果关联[J].武汉大学学报（医学版）,2025,46(03):357-364.

ZHAO Danyang,LIU Siyi,CHEN Haitao,et al.Mendelian randomization analysis of the relationship between lifestyle and the risk of osteoarthritis[J].Medical Journal of Wuhan University,2025,46(03):357-364.
赵丹阳,刘思怡,陈海涛等.孟德尔随机化分析生活习惯与骨关节炎发病风险的因果关联[J].武汉大学学报（医学版）,2025,46(03):357-364. DOI： 10.14188/j.1671-8852.2024.0102.

ZHAO Danyang,LIU Siyi,CHEN Haitao,et al.Mendelian randomization analysis of the relationship between lifestyle and the risk of osteoarthritis[J].Medical Journal of Wuhan University,2025,46(03):357-364. DOI： 10.14188/j.1671-8852.2024.0102.

摘要

目的

通过孟德尔随机化分析来探究吸烟、饮酒和喝咖啡与骨关节炎之间的因果关联。

方法

从已发表的全基因组关联研究（GWAS）中选择并提取吸烟、饮酒和喝咖啡这3个生活习惯相关特征的工具变量，手骨关节炎、膝骨关节炎和髋骨关节炎的工具变量也来自公开的全基因组关联研究。采用逆方差加权法（IVW）作为主要分析方法，同时采用孟德尔随机化⁃Egger回归、加权中位数法、MR⁃PRESSO等方法检测和校正结果。

结果

逆方差加权法结果表明，吸烟与骨关节炎之间存在因果关联（膝骨关节炎：

0.05，膝和/或髋骨关节炎：

0.05），喝咖啡与骨关节炎之间存在因果关联（膝骨关节炎：

=0.01，膝和/或髋骨关节炎：

=0.03），饮酒与骨关节炎之间没有因果关联（

0.05）。

结论

吸烟和喝咖啡与骨关节炎之间存在因果关联，而没有足够的证据表明饮酒和骨关节炎之间存在因果关联。

Abstract

Objective

To investigate the association between smoking

drinking

coffee consumption

and the risk of osteoarthritis through Mendelian randomization analysis.

Methods

Instrumental variables for smoking

alcohol consumption

and coffee consumption were selected and extracted from published genome⁃wide association studies (GWAS)

and instrumental variables for hand osteoarthritis

knee osteoarthritis

and hip osteoarthritis were also derived from publicly available genome⁃wide association studies. The inverse variance weighting (IVW) method was used as the main analysis method

and MR⁃Egger regression

weighted median method

MR⁃PRESSO

and other methods were used to detect and correct the results.

Results

The results of the inverse variance weighting method showed that smoking was positively causal with the risk of osteoarthritis (knee osteoarthritis:

0.05; knee and/or hip osteoarthritis:

0.05)

coffee consumption was positively causal with the risk of osteoarthritis (knee osteoarthritis:

=0.01; knee and/or hip osteoarthritis:

=0.03)

and there was no causal association between drinking and osteoarthritis (

0.05).

Conclusion

There is a genetic causal association between smoking and coffee consumption and osteoarthritis

whereas there is insufficient evidence for a genetic causal association between drinking and osteoarthritis.

关键词

Keywords

references

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