长期空气污染与中老年人群心脏代谢性多发病关联的横断面研究

王紫薇; 吕放; 李君真; 钟琳玲; 李行; 秦娟娟; 叶旭军

doi:10.14188/j.1671-8852.2024.0068

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长期空气污染与中老年人群心脏代谢性多发病关联的横断面研究

基础及临床医学研究 | 更新时间：2026-11-05

- 长期空气污染与中老年人群心脏代谢性多发病关联的横断面研究
- A cross⁃sectional study of the association between long⁃term air pollution and cardiometabolic multimorbidity in middle⁃aged and elderly populations
- 武汉大学学报（医学版） 2025年46卷第4期页码：480-486
- 作者机构：
  
  1.武汉大学中南医院老年病科湖北武汉 430071
  2.武汉大学护理学院健康老龄化研究中心湖北武汉 430071
- 作者简介：
  
  王紫薇，女，1997—，医学硕士生，主要从事老年共病及代谢方向研究，E⁃mail：wzw0801.whu.edu.cn
  叶旭军，男，1971—，医学博士，主任医师，副教授，博士生导师，主要从事老年疾病临床研究，E⁃mail：wdxjy@whu.edu.cn
- 基金信息：
  
  国家自然科学基金面上项目(82370074)
- DOI：10.14188/j.1671-8852.2024.0068
  中图分类号： R541.8
- 收稿：2024-01-25，
  
  纸质出版：2025-04-25
- 稿件说明：
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王紫薇,吕放,李君真等.长期空气污染与中老年人群心脏代谢性多发病关联的横断面研究[J].武汉大学学报（医学版）,2025,46(04):480-486.

WANG Ziwei,LÜ Fang,LI Junzhen,et al.A cross⁃sectional study of the association between long⁃term air pollution and cardiometabolic multimorbidity in middle⁃aged and elderly populations[J].Medical Journal of Wuhan University,2025,46(04):480-486.
王紫薇,吕放,李君真等.长期空气污染与中老年人群心脏代谢性多发病关联的横断面研究[J].武汉大学学报（医学版）,2025,46(04):480-486. DOI： 10.14188/j.1671-8852.2024.0068.

WANG Ziwei,LÜ Fang,LI Junzhen,et al.A cross⁃sectional study of the association between long⁃term air pollution and cardiometabolic multimorbidity in middle⁃aged and elderly populations[J].Medical Journal of Wuhan University,2025,46(04):480-486. DOI： 10.14188/j.1671-8852.2024.0068.

摘要

目的

探讨长期空气污染，特别是细颗粒物（PM

2.5

）及其组分与心脏代谢性多发病（CMM）之间的关联。

方法

利用中国健康与退休追踪调查（CHARLS）中2015年全国人口数据，收集我国15 632名45岁及以上的参与者人口学特征及疾病状态。使用中国空气污染追踪系统（TAP）获取气象数据。采用二元逻辑回归分析探讨PM

2.5

及其化学成分与CMM之间的关系。

结果

研究结果显示，纳入的参与者中有12.5%的人群患有CMM。PM

2.5

及其组分的暴露与CMM的患病存在显著正相关。3年累积的黑碳（BC）暴露对CMM的风险最高（

=1.147，95%

：1.083~1.214）。女性和老年人更容易受到空气污染风险的影响。

结论

本研究强调了解决空气污染作为预防和管理CMM的关键因素的重要性，特别是在易受影响的人群中。

Abstract

Objective

To investigate the association between long⁃term air pollution

particularly particulate matter （PM

2.5

） and its components

and cardiometabolic multimorbidity (CMM).

Methods

We utilized population data from the China health and retirement longitudinal study (CHARLS)

including 15 632 individuals aged 45 years and above. Meteorological data

obtained from the tracking air pollution in China (TAP) system

provided information on PM

2.5

and its chemical composition. Binary logistic regression analysis was conducted to explore the relationship between PM

2.5

and its chemical components and CMM.

Results

The study revealed that 12.5% of the population had CMM. Long⁃term exposure to PM

2.5

and its components showed a significant positive association with CMM prevalence. Among the components

black carbon demonstrated the highest risk of CMM over a 3⁃year period (

=1.147;95%

: 1.083⁃1.214). Additionally

females and older individuals were more vulnerable to the risk of air pollution.

Conclusion

These findings emphasize the importance of addressing air pollution as a key factor in CMM prevention and management

particularly among susceptible populations. Measures targeting the reduction of air pollution should be implemented to mitigate the adverse impacts and ultimately improve public health outcomes.

关键词

Keywords

references

Emerging Risk Factors Collaboration , DI ANGELANTONIO E , KAPTOGE S , et al . Association of cardiometabolic multimorbidity with mortality [J ] . JAMA , 2015 , 314 ( 1 ): 52 ⁃ 60 .

XU X L , MISHRA G D , JONES M . Evidence on multimorbidity from definition to intervention: An overview of systematic reviews [J ] . Ageing Res Rev , 2017 , 37 : 53 ⁃ 68 .

Collaborators G 2 DAI. Global burden of 369 diseases and injuries in 204 countries and territories, 1990⁃2019: A systematic analysis for the Global Burden of Disease Study 2019 [J ] . Lancet , 2020, 396 ( 10258 ): 1204 ⁃ 1222 .

YAO S S , CAO G Y , HAN L , et al . Prevalence and patterns of multimorbidity in a nationally representative sample of older Chinese: Results from the China health and retirement longitudinal study [J ] . J Gerontol A Biol Sci Med Sci , 2020 , 75 ( 10 ): 1974 ⁃ 1980 .

GBD Risk Factors Collaborators . Global burden of 87 risk factors in 204 countries and territories, 1990⁃2019: A systematic analysis for the Global Burden of Disease Study 2019 [J ] . Lancet , 2020 , 396 ( 10258 ): 1223 ⁃ 1249 .

CAI Y Y , ZHANG B , KE W X , et al . Associations of short⁃term and long⁃term exposure to ambient air pollutants with hypertension: A systematic review and meta⁃analysis [J ] . Hypertension , 2016 , 68 ( 1 ): 62 ⁃ 70 .

LIANG F C , LIU F C , HUANG K Y , et al . Long⁃term exposure to fine particulate matter and cardiovascular disease in China [J ] . J Am Coll Cardiol , 2020 , 75 ( 7 ): 707 ⁃ 717 .

HUANG K Y , LIANG F C , YANG X L , et al . Long term exposure to ambient fine particulate matter and incidence of stroke: Prospective cohort study from the China⁃PAR project [J ] . BMJ , 2019 , 367 : l6720 .

HU K , KEENAN K , HALE J M , et al . A longitudinal analysis of PM 2.5 exposure and multimorbidity clusters and accumulation among adults aged 45⁃85 in China [J ] . PLoS Glob Public Health , 2022 , 2 ( 6 ): e0000520 .

CHEN W , WANG X Y , CHEN J , et al . Household air pollution, adherence to a healthy lifestyle, and risk of cardiometabolic multimorbidity: Results from the China health and retirement longitudinal study [J ] . Sci Total Environ , 2023 , 855 : 158896 .

LUO H H , ZHANG Q L , YU K X , et al . Long⁃term exposure to ambient air pollution is a risk factor for trajectory of cardiometabolic multimorbidity: A prospective study in the UK Biobank [J ] . EBioMedicine , 2022 , 84 : 104282 .

ZHAO Y , HU Y , SMITH J P , et al . Cohort profile: The China health and retirement longitudinal study (CHARLS) [J ] . Int J Epidemiol , 2014 , 43 ( 1 ): 61 ⁃ 68 .

GENG G N , ZHANG Q , TONG D , et al . Chemical composition of ambient PM 2.5 over China and relationship to precursor emissions during 2005⁃2012 [J ] . Atmos Chem Phys Discuss , 2017 , 17 ( 14 ): 9187 ⁃ 9203 .

GENG G N , XIAO Q Y , LIU S G , et al . Tracking air pollution in China: Near real⁃time PM 2.5 retrievals from multisource data fusion [J ] . Environ Sci Technol , 2021 , 55 ( 17 ): 12106 ⁃ 12115 .

ALBERTI K G , ECKEL R H , GRUNDY S M , et al . Harmonizing the metabolic syndrome: A joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity [J ] . Circulation , 2009 , 120 ( 16 ): 1640 ⁃ 1645 .

HAN X , CAO M , PAN Z , et al . Association between long⁃term exposure to PM 2.5 constituents and electrocardiographic abnormality: A nationwide longitudinal study in China [J ] . Environ Int , 2023 , 178 : 108130

ZHANG Y , LIU L , ZHANG L , et al . Assessing short⁃term impacts of PM 2.5 constituents on cardiorespiratory hospitalizations: Multi⁃city evidence from China [J ] . Int J Hyg Environ Health , 2022 , 240 : 113912 .

ZHOU P , MO S , PENG M , et al . Long⁃term exposure to PM 2.5 constituents in relation to glucose levels and diabetes in middle⁃aged and older Chinese [J ] . Ecotoxicol Environ Saf , 2022 , 245 : 114096 .

KAUFMAN J D , ADAR S D , BARR R G , et al . Association between air pollution and coronary artery calcification within six metropolitan areas in the USA (the Multi⁃Ethnic Study of Atherosclerosis and Air Pollution): A longitudinal cohort study [J ] . Lancet (London, England) , 2016 , 388 ( 10045 ): 696 ⁃ 704 .

LU H , WANG R , LI J , et al . Long⁃term exposure to the components of fine particulate matters and disability after stroke: Findings from the China National Stroke Screening Surveys [J ] . J Hazard Mater , 2023 , 460 : 132244 .

MALLAH M A , SOOMRO T , ALI M , et al . Cigarette smoking and air pollution exposure and their effects on cardiovascular diseases [J ] . Front Public Health , 2023 , 11 : 967047 .

LI B , LIANG Y , BAO H , et al . Real⁃ambient particulate matter exposure⁃induced FGFR1 methylation contributes to cardiac dysfunction via lipid metabolism disruption [J ] . Sci Total Environ , 2023 , 870 : 161903 .

ZHU X , LIU B , GUO C , et al . Short and long⁃term association of exposure to ambient black carbon with all⁃cause and cause⁃specific mortality: A systematic review and meta⁃analysis [J ] . Environ Pollut , 2023 , 324 : 121086 .

RASKING L , KOSHY P , BONGAERTS E , et al . Ambient black carbon reaches the kidneys [J ] . Environ Int , 2023 , 177 : 107997 .

LIAO M , BRAUNSTEIN Z , RAO X . Sex differences in particulate air pollution⁃related cardiovascular diseases: A review of human and animal evidence [J ] . Sci Total Environ , 2023 , 884 : 163803 .

WANG Y , XIONG L , HUANG X , et al . Intermittent exposure to airborne particulate matter induces subcellular dysfunction and aortic cell damage in BALB/c mice through multi⁃endpoint assessment at environmentally relevant concentrations [J ] . J Hazard Mater , 2022 , 424 : 127169 .

KIM J S , CHEN Z , ALDERETE T L , et al . Associations of air pollution, obesity and cardiometabolic health in young adults: The Meta⁃AIR study [J ] . Environ Int , 2019 , 133 : 105180 .

KIM H J , KWON H , YUN J M , et al . Interaction between visceral adiposity and ambient air pollution on LDL cholesterol level in Korean adults [J ] . Int J Obes (Lond) , 2021 , 45 ( 3 ): 1 ⁃ 8 .

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