中药单体通过靶向NLRP3炎症小体改善子痫前期的研究进展

陈婷婷; 范翠芳

doi:10.14188/j.1671-8852.2024.0064

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中药单体通过靶向NLRP3炎症小体改善子痫前期的研究进展

中药活性成分的作用机制研究 | 更新时间：2026-11-05

- 中药单体通过靶向NLRP3炎症小体改善子痫前期的研究进展
- Research progress on Chinese medicine monomers targeting NLRP3 inflammasomes to ameliorate preeclampsia
- 武汉大学学报（医学版） 2025年46卷第4期页码：419-423
- 作者机构：
  
  武汉大学人民医院产科湖北武汉 430060
- 作者简介：
  
  陈婷婷，女，2000—，医学硕士生，主要从事围产医学的研究，E‑mail:chentingting@whu.edu.cn
  范翠芳，女，1967—，医学博士，主任医师，教授，硕士生导师，主要从事围产医学的研究，E‑mail: fancuifang@whu.edu.cn
- 基金信息：
  
  国家重点研发计划项目(2021YFC2700700)
- DOI：10.14188/j.1671-8852.2024.0064
  中图分类号： R714.7
- 收稿：2024-01-24，
  
  纸质出版：2025-04-25
- 稿件说明：
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陈婷婷,范翠芳.中药单体通过靶向NLRP3炎症小体改善子痫前期的研究进展[J].武汉大学学报（医学版）,2025,46(04):419-423.

CHEN Tingting,FAN Cuifang.Research progress on Chinese medicine monomers targeting NLRP3 inflammasomes to ameliorate preeclampsia[J].Medical Journal of Wuhan University,2025,46(04):419-423.
陈婷婷,范翠芳.中药单体通过靶向NLRP3炎症小体改善子痫前期的研究进展[J].武汉大学学报（医学版）,2025,46(04):419-423. DOI： 10.14188/j.1671-8852.2024.0064.

CHEN Tingting,FAN Cuifang.Research progress on Chinese medicine monomers targeting NLRP3 inflammasomes to ameliorate preeclampsia[J].Medical Journal of Wuhan University,2025,46(04):419-423. DOI： 10.14188/j.1671-8852.2024.0064.

摘要

子痫前期是伴有多种器官功能障碍的妊娠期并发症，目前认为炎症免疫反应过度激活是促进子痫前期发生和发展发病机制之一，其中NLRP3炎症小体作为炎症反应重要介质可以通过介导细胞焦亡促进IL‑1β、IL‑18等促炎症因子的释放，加剧母体局部或全身炎症水平。中药单体抗炎、抗氧化应激等药理学作用能明显改善子痫前期的病理生理变化，因此本文就中药单体靶向NLRP3炎症小体通路防治子痫前期相关机制进行综述。

Abstract

Preeclampsia is a pregnancy complication characterized by multiple organ dysfunction. The overactivation of the inflammatory immune response is currently considered one of the mechanisms that promotes the occurrence and development of preeclampsia. NLRP3 inflammasomes

as an important mediator of the inflammatory response

can trigger pyroptosis. The release of pro⁃inflammatory factors such as IL⁃1β and IL⁃18 worsens local or systemic inflammation and accelerates the progression of preeclampsia. Chinese medicine monomers

with their pharmacological effects of anti-inflammation and antioxidant stress

can significantly improve the pathological and physiological changes of preeclampsia. Therefore

this article reviews the relevant mechanisms of Chinese medicine monomers targeting the NLRP3 inflammasome pathway in the prevention and treatment of preeclampsia.

关键词

Keywords

references

POON L C , SHENNAN A , HYETT J A , et al . The International Federation of Gynecology and Obstetrics (FIGO) initiative on pre‑eclampsia: A pragmatic guide for first‑trimester screening and prevention [J ] . Int J Gynaecol Obstet , 2019 , 145 ( Suppl 1 ): 1 ‑ 33 .

WEEL I C , ROMÃO‑VEIGA M , MATIAS M L , et al . Increased expression of NLRP3 inflammasome in placentas from pregnant women with severe preeclampsia [J ] . J Reprod Immunol , 2017 , 123 : 40 ‑ 47 .

DIMITRIADIS E , ROLNIK D L , ZHOU W , et al . Pre‑eclampsia [J ] . Nat Rev Dis Primers , 2023 , 9 ( 1 ): 8 .

SHARMA B R , KANNEGANTI T D . NLRP3 inflammasome in cancer and metabolic diseases [J ] . Nat Immunol , 2021 , 22 ( 5 ): 550 ‑ 559 .

ZHAO Z H , XU B H , WANG S , et al . Tfh cells with NLRP3 inflammasome activation are essential for high‑affinity antibody generation, germinal centre formation and autoimmunity [J ] . Ann Rheum Dis , 2022 , 81 ( 7 ): 1006 ‑ 1012 .

FU J N , WU H . Structural mechanisms of NLRP3 inflammasome assembly and activation [J ] . Annu Rev Immunol , 2023 , 41 : 301 ‑ 316 .

LIM R , LAPPAS M . NOD‑like receptor pyrin domain‑containing‑3 (NLRP3) regulates inflammation‑induced pro‑labor mediators in human myometrial cells [J ] . Am J Reprod Immunol , 2018 , 79 ( 4 ): e12825 .

BRYANT A H , BEVAN R J , SPENCER‑HARTY S , et al . Expression and function of NOD‑like receptors by human term gestation‑associated tissues [J ] . Placenta , 2017 , 58 : 25 ‑ 32 .

XU L Q , LI S , LIU Z , et al . The NLRP3 rs10754558 polymorphism is a risk factor for preeclampsia in a Chinese Han population [J ] . J Matern Fetal Neonatal Med , 2019 , 32 ( 11 ): 1792 ‑ 1799 .

BIANCHI M E . DAMPs,PAMPs and alarmins:All we need to know about danger [J ] . J Leukoc Biol , 2007 , 81 ( 1 ): 1 ‑ 5 .

LIU Z C , ZHAO X , SHAN H Y , et al . MicroRNA‑520c‑3p suppresses NLRP3 inflammasome activation and inflammatory cascade in preeclampsia by downregulating NLRP3 [J ] . Inflamm Res , 2019 , 68 ( 8 ): 643 ‑ 654 .

DÍAZ‑GARCÍA E , SANZ‑RUBIO D , GARCÍA‑TOVAR S , et al . Inflammasome activation mediated by oxidised low‑density lipoprotein in patients with sleep apnoea and early subclinical atherosclerosis [J ] . Eur Respir J , 2023 , 61 ( 3 ): 2201401 .

VAKA V R , MCMASTER K M , CUNNINGHAM M W , et al . Role of mitochondrial dysfunction and reactive oxygen species in mediating hypertension in the reduced uterine perfusion pressure rat model of preeclampsia [J ] . Hypertension , 2018 , 72 ( 3 ): 703 ‑ 711 .

BILLINGHAM L K , STOOLMAN J S , VASAN K , et al . Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation [J ] . Nat Immunol , 2022 , 23 ( 5 ): 692 ‑ 704 .

LIAN I A , LØSET M , MUNDAL S B , et al . Increased endoplasmic reticulum stress in decidual tissue from pregnancies complicated by fetal growth restriction with and without pre‑eclampsia [J ] . Placenta , 2011 , 32 ( 11 ): 823 ‑ 829 .

MUKHERJEE I , DHAR R , SINGH S , et al . Oxidative stress‑induced impairment of trophoblast function causes preeclampsia through the unfolded protein response pathway [J ] . Sci Rep , 2021 , 11 ( 1 ): 18415 .

CHENG S B , NAKASHIMA A , HUBER W J , et al . Pyroptosis is a critical inflammatory pathway in the placenta from early onset preeclampsia and in human trophoblasts exposed to hypoxia and endoplasmic reticulum stressors [J ] . Cell Death Dis , 2019 , 10 ( 12 ): 927 .

QUAN X Z , YE J H , YANG X Z , et al . HOXA9‑induced chemerin signals through CMKLR1/AMPK/TXNIP/NLRP3 pathway to induce pyroptosis of trophoblasts and aggravate preeclampsia [J ] . Exp Cell Res , 2021 , 408 ( 2 ): 112802 .

XIAO G R , TANG R , YANG N , et al . Review on pharmacological effects of gastrodin [J ] . Arch Pharm Res , 2023 , 46( 9 ⁃ 10 ): 744 ‑ 770 .

MEI Z X , HUANG B Q , QIAN X L , et al . Gastrodin improves preeclampsia‑induced cell apoptosis by regulation of TLR4/NF‑κB in rats [J ] . Food Sci Nutr , 2020 , 8 ( 2 ): 820 ‑ 829 .

SUN W J , LU H Q , LYU L C , et al . Gastrodin ameliorates microvascular reperfusion injury‑induced pyroptosis by regulating the NLRP3/caspase‑1 pathway [J ] . J Physiol Biochem , 2019 , 75 ( 4 ): 531 ‑ 547 .

CAI J S , HUANG K L , HAN S N , et al . A comprehensive system review of pharmacological effects and relative mechanisms of Ginsenoside Re: Recent advances and future perspectives [J ] . Phytomedicine , 2022 , 102 : 154119 .

LIU S L , CHEN W J , ZHAO Y , et al . Research progress on effects of ginsenoside Rg2 and Rh1 on nervous system and related mechanisms [J ] . Molecules , 2023 , 28 ( 23 ): 7935 .

CAI L Y , HU F F , FU W W , et al . Ginsenoside Rg2 ameliorates brain injury after intracerebral hemorrhage in a rat model of preeclampsia [J ] . Reprod Sci , 2021 , 28 ( 12 ): 3431 ‑ 3439 .

MARTIN J N , THIGPEN B D , MOORE R C , et al . Stroke and severe preeclampsia and eclampsia: A paradigm shift focusing on systolic blood pressure [J ] . Obstet Gynecol , 2005 , 105 ( 2 ): 246 ‑ 254 .

REN B , FENG J P , YANG N , et al . Ginsenoside Rg3 attenuates angiotensin Ⅱ‑induced myocardial hypertrophy through repressing NLRP3 inflammasome and oxidative stress via modulating SIRT1/NF‑κB pathway [J ] . Int Immunopharmacol , 2021 , 98 : 107841 .

SIROTKIN A V . Quercetin action on health and female reproduction in mammals [J ] . Crit Rev Food Sci Nutr , 2023 : 1 ‑ 15 . DOI: 10.1080/10408398.2023.2256001 http://dx.doi.org/10.1080/10408398.2023.2256001 .

LI Q H , YIN L X , SI Y R , et al . The bioflavonoid quercetin improves pathophysiology in a rat model of preeclampsia [J ] . Biomed Pharmacother , 2020 , 127 : 110122 .

YANG S Y , SONG L L , SHI X F , et al . Ameliorative effects of pre‑eclampsia by quercetin supplement to aspirin in a rat model induced by L‑NAME [J ] . Biomed Pharmacother , 2019 , 116 : 108969 .

YANG S Y , ZHANG J F , CHEN D , et al . Quercetin supplement to aspirin attenuates lipopolysaccharide‑induced pre‑eclampsia‑like impairments in rats through the NLRP3 inflammasome [J ] . Drugs R D , 2022 , 22 ( 4 ): 271 ‑ 279 .

RAMLI I , POSADINO A M , GIORDO R , et al . Effect of resveratrol on pregnancy, prenatal complications and pregnancy‑associated structure alterations [J ] . Antioxidants , 2023 , 12 ( 2 ): 341 .

DING J , KANG Y , FAN Y Q , et al . Efficacy of resveratrol to supplement oral nifedipine treatment in pregnancy‑induced preeclampsia [J ] . Endocr Connect , 2017 , 6 ( 8 ): 595 ‑ 600 .

LANG X , LIU W , CHEN Q F , et al . Resveratrol inhibits multiple organ injury in preeclampsia rat model [J ] . Acta Biochim Pol , 2023 , 70 ( 1 ): 131 ‑ 135 .

RAIA‑BARJAT T , EDEBIRI O , NI AINLE F . Preeclampsia and venous thromboembolism: Pathophysiology and potential therapy [J ] . Front Cardiovasc Med , 2022 , 9 : 856923 .

FEI J W , QIN X , MA H F , et al . Resveratrol ameliorates deep vein thrombosis‑induced inflammatory response through inhibiting HIF‑1α/NLRP3 pathway [J ] . Inflammation , 2022 , 45 ( 6 ): 2268 ‑ 2279 .

KONG J Y , LI S J , LI Y T , et al . Effects of Salvia miltiorrhiza active compounds on placenta‑mediated pregnancy complications [J ] . Front Cell Dev Biol , 2023 , 11 : 1034455 .

SHEN Y , HU Y L , ZHANG Y . Favorable maternal and fetal effects of danshensu in an experimental mice model of preeclampsia [J ] . Hypertens Pregnancy , 2011 , 30 ( 4 ): 465 ‑ 480 .

MA Q X , YANG Q Q , CHEN J J , et al . Salvianolic acid A ameliorates early‑stage atherosclerosis development by inhibiting NLRP3 inflammasome activation in zucker diabetic fatty rats [J ] . Molecules , 2020 , 25 ( 5 ): 1089 .

LIU H B , ZHAN X Y , XU G , et al . Cryptotanshinone specifically suppresses NLRP3 inflammasome activation and protects against inflammasome‑mediated diseases [J ] . Pharmacol Res , 2021 , 164 : 105384 .

DE SOUZA C O , PERAÇOLI MTS , WEEL I C , et al . Hepatoprotective and anti‑inflammatory effects of silibinin on experimental preeclampsia induced by L‑NAME in rats [J ] . Life Sci , 2012 , 91 ( 5/6 ): 159 ‑ 165 .

RIBEIRO V R , ROMAO‑VEIGA M , NUNES P R , et al . Silibinin downregulates the expression of the Th1 and Th17 profiles by modulation of STATs and transcription factors in pregnant women with preeclampsia [J ] . Int Immunopharmacol , 2022 , 109 : 108807 .

DALEY D , MANI V R , MOHAN N , et al . NLRP3 signaling drives macrophage‑induced adaptive immune suppression in pancreatic carcinoma [J ] . J Exp Med , 2017 , 214 ( 6 ): 1711 ‑ 1724 .

MATIAS M L , GOMES V J , ROMAO‑VEIGA M , et al . Silibinin downregulates the NF‑κB pathway and NLRP1/NLRP3 inflammasomes in monocytes from pregnant women with preeclampsia [J ] . Molecules , 2019 , 24 ( 8 ): 1548 .

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