复方脑肽节苷脂注射液治疗创伤性骨折周围神经损伤的效果

关翰辉; 岑超德; 彭龙; 刘承伟

doi:10.14188/j.1671-8852.2023.0677

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复方脑肽节苷脂注射液治疗创伤性骨折周围神经损伤的效果

中药活性成分的作用机制研究 | 更新时间：2026-11-05

- 复方脑肽节苷脂注射液治疗创伤性骨折周围神经损伤的效果
- Effect of compound brain peptide ganglioside injection on the treatment of peripheral nerve injury in traumatic fractures
- 武汉大学学报（医学版） 2025年46卷第4期页码：424-429
- 作者机构：
  
  北京积水潭医院贵州医院贵州贵阳 550014
- 作者简介：
  
  关翰辉,男，1984—，主治医师，主要从事上肢创伤、手显微外科研究，E‑mail:guanhanhui2021@163.com
  岑超德,男，1989—，医学博士生，主治医师，主要从事纳米磁性药物靶向研究、骨修复材料、骨组织工程研究，E‑mail:894719228@qq.com
- 基金信息：
  
  贵州省科学技术厅资助项目（黔科合基础‑ZK[2021一般389]）
- DOI：10.14188/j.1671-8852.2023.0677
  中图分类号： R927
- 收稿：2023-12-14，
  
  纸质出版：2025-04-25
- 稿件说明：
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关翰辉,岑超德,彭龙等.复方脑肽节苷脂注射液治疗创伤性骨折周围神经损伤的效果[J].武汉大学学报（医学版）,2025,46(04):424-429.

GUAN Hanhui,CEN Chaode,PENG Long,et al.Effect of compound brain peptide ganglioside injection on the treatment of peripheral nerve injury in traumatic fractures[J].Medical Journal of Wuhan University,2025,46(04):424-429.
关翰辉,岑超德,彭龙等.复方脑肽节苷脂注射液治疗创伤性骨折周围神经损伤的效果[J].武汉大学学报（医学版）,2025,46(04):424-429. DOI： 10.14188/j.1671-8852.2023.0677.

GUAN Hanhui,CEN Chaode,PENG Long,et al.Effect of compound brain peptide ganglioside injection on the treatment of peripheral nerve injury in traumatic fractures[J].Medical Journal of Wuhan University,2025,46(04):424-429. DOI： 10.14188/j.1671-8852.2023.0677.

摘要

目的

探讨复方脑肽节苷脂注射液治疗创伤性骨折周围神经损伤的效果。

方法

纳入2020年8月—2022年12月107例创伤性骨折周围神经损伤患者，以随机数表法分为对照组（

=53）和观察组（

=54）。对照组口服甲钴胺片治疗，观察组在对照组基础上加用复方脑肽节苷脂注射液治疗，两组均治疗2周。比较患者住院时间、治疗前后神经电生理指标[运动神经传导速度（MNCV）、感觉神经传导速度（SNCV）

]

、神经营养因子[睫状神经营养因子（CNTF）、脑源性神经营养因子（BDNF）

]

、核转录因子κB（NF‑κB）、肿瘤坏死因子（TNF‑α）、用药不良反应。

结果

观察组住院时间短于对照组[（18.83±3.42） d

（20.75±4.06） d

]

（

0.05）。治疗前后MNCV、SNCV、CNTF、BDNF、NF‑κB、TNF‑α的主效应差异有统计学意义（

0.05）；不考虑测量时间，两组间MNCV、SNCV、CNTF、BDNF、NF‑κB、TNF‑α的主效应差异有统计学意义（

0.05）；MNCV、SNCV、CNTF、BDNF、NF‑κB、TNF‑α的时间点与组间存在交互作用（

0.05），两组治疗前后MNCV、SNCV、CNTF、BDNF、NF‑κB、TNF‑α的变化幅度不同，观察组变化更明显（

0.05）。两组用药不良反应比较，差异均无统计学意义（

0.05）。

结论

复方脑肽节苷脂注射液治疗创伤性骨折周围神经损伤安全有效，可加快运动及感觉神经传导速度，促进患者尽快恢复，其机制可能与上调CNTF、BDNF及下调NF‑κB、TNF‑α水平有关。

Abstract

Objective

To explore the efficacy of compound brain peptide ganglioside injection in treating peripheral nerve injury in traumatic fractures.

Methods

A total of 107 patients with trau

matic fracture and peripheral nerve injury were included from August 2020 to December 2022. Using a random number table method

they were randomly divided into a control group (

=53) and an observation group (

=54). The control group was treated with mecobalamin tablets

while the observation group was treated with compound brain peptide ganglioside injection based on the control group. Both groups were treated for 2 weeks. The hospitalization time

nerve electrophysiological indexes (motor nerve conduction velocity (MNCV)

sensory nerve conduction velocity (SNCV))

neurotrophic factors (ciliary neurotrophic factor (CNTF)

brain‑derived neurotrophic factor (BDNF))

nuclear transcription factor κB (NF‑κB)

tumor necrosis factor (TNF‑α)

and adverse drug reactions were compared before and after treatment.

Results

The hospitalization time in the observation group was shorter than that in the control group

as (18.83±3.42) d versus (20.75±4.06) d

0.05. The main effect differences of MNCV

SNCV

CNTF

BDNF

NF‑κB

and TNF‑α before and after treatment were statistically significant (

0.05). Regardless of the measurement time

there was a statistically significant difference in the main effects of MNCV

SNCV

CNTF

BDNF

NF‑κB

and TNF‑α between the two groups (

0.05). There was an interaction between the time points and groups in MNCV

SNCV

CNTF

BDNF

NF‑κB

and TNF‑α (

0.05). The amplitude of changes in MNCV

SNCV

CNTF

BDNF

NF‑κB

and TNF‑α was different between the two groups before and after treatment

and the observation group showed more significant changes (

0.05). There was no statistically significant difference in adverse reactions between the two groups (

0.05).

Conclusion

Compound brain peptide ganglioside injection is safe and effective in the treatment of traumatic fracture peripheral nerve injury and can accelerate the motor and sensory nerve conduction velocity

promoting patients' recovery. Its mechanism may be related to the up⁃regulation of CNTF and BDNF levels and the down⁃regulation of NF‑κB and TNF‑α levels.

关键词

Keywords

references

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