腰椎间盘突出症患者血清SDF‑1、MMP3、IL‑1β水平与椎间盘退变分级的相关性分析

覃玉曦; 范明宇

doi:10.14188/j.1671-8852.2023.0161

您当前的位置：

首页 >

文章列表页 >

腰椎间盘突出症患者血清SDF‑1、MMP3、IL‑1β水平与椎间盘退变分级的相关性分析

临床医学研究 | 更新时间：2026-11-05

- 腰椎间盘突出症患者血清SDF‑1、MMP3、IL‑1β水平与椎间盘退变分级的相关性分析
- Correlation analysis between serum SDF‑1, MMP 3, IL‑1β and grade of intervertebral disc degeneration in patients with lumbar disc herniation
- 武汉大学学报（医学版） 2025年46卷第3期页码：381-386
- 作者机构：
  
  1.武汉市第三医院，医务部，湖北武汉 430060
  2.武汉市第三医院，骨一科，湖北武汉 430060
- 作者简介：
  
  覃玉曦，女，1986—，医学硕士，主管中药师，主要从事医政管理和药学科研方面研究，E‑mail：398963138@qq.com
  范明宇，男，1982—，医学硕士，副主任医师，主要从事脊柱外科的临床科研和教学研究，E‑mail：21872407@qq.com
- 基金信息：
  
  武汉市卫生健康委医学科研项目‑青年项目(WX20Q09)
- DOI：10.14188/j.1671-8852.2023.0161
  中图分类号： R681.53
- 收稿：2023-03-12，
  
  纸质出版：2025-03-25
- 稿件说明：
移动端阅览
覃玉曦,范明宇.腰椎间盘突出症患者血清SDF‑1、MMP3、IL‑1β水平与椎间盘退变分级的相关性分析[J].武汉大学学报（医学版）,2025,46(03):381-386.

QIN Yuxi,FAN Mingyu.Correlation analysis between serum SDF‑1, MMP 3, IL‑1β and grade of intervertebral disc degeneration in patients with lumbar disc herniation[J].Medical Journal of Wuhan University,2025,46(03):381-386.
覃玉曦,范明宇.腰椎间盘突出症患者血清SDF‑1、MMP3、IL‑1β水平与椎间盘退变分级的相关性分析[J].武汉大学学报（医学版）,2025,46(03):381-386. DOI： 10.14188/j.1671-8852.2023.0161.

QIN Yuxi,FAN Mingyu.Correlation analysis between serum SDF‑1, MMP 3, IL‑1β and grade of intervertebral disc degeneration in patients with lumbar disc herniation[J].Medical Journal of Wuhan University,2025,46(03):381-386. DOI： 10.14188/j.1671-8852.2023.0161.

摘要

目的

探讨血清基质细胞衍生因子（SDF‑1）、基质金属蛋白酶‑3（MMP3）、白细胞介素‑1β（IL‑1β）与腰椎间盘突出症（LDH）患者椎间盘退变分级的相关性。

方法

选取2020年7月至2022年7月武汉市第三医院收治的LDH患者150例作为观察组，另选同期90例体检为正常椎间盘组织作为健康对照组；对比两组血清SDF‑1、MMP3、IL‑1β表达水平；参照Pfirrmann分级标准将观察组患者分为椎间盘退变Ⅲ级、Ⅳ级、Ⅴ级，对比L4/5、L5/S1节段椎间盘退变不同级别的血清SDF‑1、MMP3、IL‑1β表达水平，并采用Spearman相关性分析方法分析血清SDF‑1、MMP3、IL‑1β表达水平与L4/5、L5/S1节段椎间盘退变分级的相关性。

结果

观察组血清SDF‑1、MMP3、IL‑1β水平均高于对照组（

0.05）。L4/5、L5/S1节段不同腰椎间盘分级椎间盘突出症患者各亚组血清中SDF‑1、MMP3、IL‑1β水平随着病变程度增加而升高（分别为

=68.867、47.578、212.079和

=221.461、346.920、514.849；

0.05）。Spearman相关性分析结果显示：血清SDF‑1、MMP3、IL‑1β水平与L4/5、L5/S1节段腰椎间盘分级均呈正相关（分别为

=0.759、0.801、0.785和

=0.748、0.823、0.816；

0.05）。

结论

血清SDF‑1、MMP3、IL‑1β表达水平与腰椎间盘退变程度呈正相关，随着病情加重，其表达水平升高，提示血清血清SDF‑1、MMP3、IL‑1β水平与腰椎间盘退变的发生发展密切相关。

Abstract

Objective

To investigate the correlation between serum stromal cell⁃derived factor 1 (SDF‑1)

matrix metalloproteinase‑3 (MMP‑3)

interleukin‑1β （IL‑1β）

and the grade of intervertebral disc degeneration in patients with lumbar disc herniation（LDH）.

Methods

A total of 150 LDH patients admitted to our hospital from July 2020 to July 2022 were selected as the observation group

and another 90 healthy individuals with normal intervertebral disc tissue were selected as the healthy control group. The expression levels of serum SDF⁃1

MMP3

and IL⁃1β were compared between the two groups. The observation group was classified into Grade Ⅲ

Grade Ⅳ

and Grade Ⅴ of disc degeneration according to the Pfirrmann classification standard. The expression levels of serum SDF⁃1

MMP3

and IL⁃1β were compared among the different subgroups of disc herniation patients

respectively

at L4/5 and L5/S1 segments. Spearman's correlation analysis was performed to assess the relationship between the expression levels of serum SDF⁃1

MMP3

and IL⁃1β and the degeneration grade of intervertebral discs at L4/5 and L5/S1 segments.

Results

The levels of serum SDF‑1

MMP3

and IL‑1β in the observation group were higher than those in the control group (

0.05). Serum SDF‑1

MMP3

IL‑1β in different subgroups of patients with lumbar disc herniation at L4/5 and L5/S1 segments increased with the degree of lesion (

=68.867

47.578

212.079;

=221.461

346.920

514.849;

0.05). Spearman correlation analysis showed that the level of sserum SDF‑1

MMP3

and IL‑1β was positively correlated with L4/5 and L5/S1 lumbar disc classification (

=0.759

0.801

0.785;

0.748

0.823

0.816;

0.05).

Conclusion

The expression level of serum SDF‑1

MMP3

and IL‑1β was positively correlated with the degree of degeneration of the lumbar intervertebral disc. As the severity of the disease increases

their expression levels rise

suggesting a close association between serum levels of SDF⁃1

MMP3

and IL⁃1β and the development of lumbar disc degeneration.

关键词

Keywords

references

WANG Y D , A R N , XU Y Y , et al . Three‑dimensional digital measurement of the facet joint in normal individual and lumbar intervertebral disc herniation patients aged 13–18 years [J ] . Asian J Surg , 2022 , 45 ( 1 ): 269 ‑ 276 .

KURZBUCH A R , FOURNIER J Y , TULEASCA C . The annular closure device ‑ Panacea of lumbar disc herniation: How closed is closed enough for the intervertebral disc space? [J ] . Acta Neurochir (Wien) , 2021 , 163 ( 6 ): 1611 ‑ 1612 .

刘培太 , 张军 , 吴硕柱 . 骶骨倾斜角和髂嵴连线对下腰椎间盘突出症发病的影响 [J ] . 颈腰痛杂志 , 2021 , 42 ( 6 ): 801 ‑ 804 .

LIU P T , ZHANG J , WU S Z . Influence of sacral slope and iliac crest line on the incidence of lower lumbar disc herniation [J ] . J Cervicodynia Lumbodynia , 2021 , 42 ( 6 ): 801 ‑ 804 .

ROSSMAN S , MEYER E , RUNDELL S . Development of a finite element lumbar spine model to predict intervertebral disc herniation risk factors [J ] . Comput Methods Biomech Biomed Engin , 2022 , 25 ( 1 ): 1 ‑ 13 .

文浩辉 , 杨大志 , 易伟宏 . 极外侧椎间融合术入路安全性及神经并发症防治的研究进展 [J ] . 武汉大学学报(医学版) , 2021 , 42 ( 1 ): 167 ‑ 172 .

WEN H H , YANG D Z , YI W H . Research progress on the safety and prevention of neurologic complications of extreme lateral interbody fusion [J ] . Med J Wuhan Univ , 2021 , 42 ( 1 ): 167 ‑ 172 .

昝芸艳 , 刘扬 , 笪熠 , 等 . 基质细胞衍生因子‑1 alpha与Dickkopf‑1相互作用参与多发性骨髓瘤骨病发生 [J ] . 中国实验血液学杂志 , 2020 , 28 ( 5 ): 1592 ‑ 1597 .

ZAN Y Y , LIU Y , DA Y , et al . Interaction between stromal cell‑derived factor 1 alpha and dickkopf‑1 involves in occurence of myeloma bone disease [J ] . J Exp Hematol , 2020 , 28 ( 5 ): 1592 ‑ 1597 .

魏春 , 徐杰 . 腰椎间盘突出症患者外周血白细胞介素‑1β、前列腺素E2及基质金属蛋白酶‑3水平变化 [J ] . 新乡医学院学报 , 2017 , 34 ( 1 ): 76 ‑ 78 .

WEI C , XU J . Changes in the levels of peripheral blood interleukin‑1β, prostaglandin E2 and matrix metalloproteinases‑3 in patients with lubar intervertebral disc protrusion [J ] . J Xinxiang Med Univ , 2017 , 34 ( 1 ): 76 ‑ 78 .

焦锋 , 唐望 , 黄荷 , 等 . 消肿定痛合剂治疗急性腰椎间盘突出症90例临床观察及对肿瘤坏死因子‑α、α‑颗粒膜糖蛋白、白细胞‑1β、MMP‑3的干预作用 [J ] . 辽宁中医杂志 , 2020 , 47 ( 2 ): 117 ‑ 120 .

JIAO F , TANG W , HUANG H , et al . Observation of therapeutic effect of Xiaozhong Dingtong hejj in treatment of acute lumbar disc herniation and the influence on TNF‑α, CD62p, IL‑1β and MMP‑3 [J ] . Liaoning J Tradit Chin Med , 2020 , 47 ( 2 ): 117 ‑ 120 .

蒋鸣福 . 腰椎间盘突出症防治指南 [M ] . 北京 : 人民卫生出版社 , 2000 : 25 ‑ 27 .

JIANG M F . Guidelines for prevention and treatment of lumbar disc herniation [M ] . Beijing : People's Medical Publishing House , 2000 : 25 ‑ 27 .

魏明 , 高凤娇 , 杨琳 , 等 . SDF‑1/CXCR4激活ERK和PI3K/AKT通路介导髓核致炎根性疼痛 [J ] . 中山大学学报(医学科学版) , 2021 , 42 ( 3 ): 373 ‑ 380 .

WEI M , GAO F J , YANG L , et al . SDF‑1/CXCR4 activates ERK and PI3K/AKT signaling contributing to the pathogenesis of radicular pain induced by autograft of nucleus pulposus [J ] . J Sun Yat Sen Univ Med Sci , 2021 , 42 ( 3 ): 373 ‑ 380 .

FANG J Z , XU J K , ZHANG Y T , et al . Stromal cell‑derived factor‑1 may play pivotal role in distraction‑stimulated neovascularization of diabetic foot ulcer [J ] . Med Hypotheses , 2021 , 149 : 110548 .

ESMAEILI R , DARBANDI‑AZAR A , SADEGHPOUR A , et al . Mesenchymal stem cells pretreatment with stromal‑derived factor‑1 alpha augments cardiac function and angiogenesis in infarcted myocardium [J ] . Am J Med Sci , 2021 , 361 ( 6 ): 765 ‑ 775 .

汪伯毅 , 邹璟 , 黄国付 . " 夹脊"电针对轴向加压致腰椎间盘退变模型兔IL‑1β,TGF‑β1表达的影响 [J ] . 世界中西医结合杂志 , 2021 , 16 ( 5 ): 868 ‑ 872 .

WANG B Y , ZOU J , HUANG G F . Effects of "Jiaji" on expression of IL‑1β and TGF‑β1 in rabbit model of lumbar disc degeneration induced by axial compression [J ] . World Journal of Integrated Traditional Chinese and Western Medicine , 2021 , 16 ( 5 ): 868 ‑ 872 .

KIM H , HONG J Y , LEE J , et al . IL‑1β promotes disc degeneration and inflammation through direct injection of intervertebral disc in a rat lumbar disc herniation model [J ] . Spine J , 2021 , 21 ( 6 ): 1031 ‑ 1041 .

周柯 , 叶枫 . 经皮椎间孔镜技术与椎板开窗髓核摘除术治疗腰椎间盘突出症:临床疗效及组织创伤的血清学指标分析 [J ] . 颈腰痛杂志 , 2019 , 40 ( 3 ): 315 ‑ 318 .

ZHOU K , YE F . Percutaneous foraminoscopy and fenestration of the nucleus pulposus in the treatment of lumbar disc herniation: Analysis of clinical efficacy and serological indexes of tissue trauma [J ] . Journal of Neck and low back Pain , 2019 , 40 ( 3 ): 315 ‑ 318 .

彭力阳 , 陈荣彬 , 李勇 . MRI结合血清,关节液中NO,MMP3水平在膝关节类风湿与骨性关节炎的诊断价值 [J ] . 中国CT和MRI杂志 , 2020 , 18 ( 2 ): 138 ‑ 141 .

PENG L Y , CHEN R B , LI Y . Diagnostic value of MRI combined with serum, NO, MMP3 level in joint fluid in rheumatoid and osteoarthritis of knee joint [J ] . Chinese Journal of CT and MRI , 2020 , 18 ( 2 ): 138 ‑ 141 .

ZHANG S J , SONG S , ZHUANG Y , et al . RETRACTED: Role of microRNA‑15a‑5p/Sox9/NF‑κB axis in inflammatory factors and apoptosis of murine nucleus pulposus cells in intervertebral disc degeneration [J ] . Life Sci , 2021 , 277 : 119408 .

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

经皮椎间孔镜下腰椎间盘髓核摘除术和开放腰椎间髓核摘除术治疗青少年腰椎间盘突出症的临床观察

伊伐布雷定联合芪苈强心胶囊治疗老年缺血性心肌病的临床疗效及对炎症因子水平的影响

Master-Quadrant系统辅助下微创治疗腰椎间盘突出症的临床疗效

水蛭对载脂蛋白E基因敲除鼠动脉粥样硬化斑块的影响

静脉血栓栓塞症预防健康教育的研究进展