1. 四川大学华西医院康复医学中心,成都
2. 四川大学华西医院康复医学研究所,成都
3. 康复医学四川省重点实验室,成都
4. 香港中文大学生物医学科学学院,香港
5. 香港中文大学组织工程与再生医学研究所,香港
纸质出版:2024
移动端阅览
徐扬, 王谦, 汪香秀, 等. 间充质干细胞外泌体在骨关节炎再生康复中应用和研究进展[J]. 中华物理医学与康复杂志, 2024,46(9):860-864.
徐扬, 王谦, 汪香秀, et al. 间充质干细胞外泌体在骨关节炎再生康复中应用和研究进展[J]. 2024, 46(9): 860-864.
骨关节炎是临床常见疾病之一
也是最常见的关节炎形式
是导致老年人残疾的主要原因。间充质干细胞疗法已在动物研究和临床试验中证明了其对于软骨修复的有效性
且间充质干细胞的治疗作用被越来越多地归因于旁分泌和外泌体。关节腔内注射间充质干细胞分泌的外泌体作为一种新的骨关节炎治疗方式
具有促进软骨修复和再生、减轻炎症反应和免疫调节的作用
已经成为了治疗骨关节炎的新热点。现有研究证明
间充质干细胞的外泌体在骨关节炎动物模型中普遍具有促进软骨修复、缓解炎症、减轻疼痛以及延缓骨关节炎进展的作用。本综述旨在总结间充质干细胞产生的外泌体在骨关节炎再生康复中的应用与研究进展
为其未来的研究提供参考。
李苏亚,奚广军,李在望,张剑平.间充质干细胞源外泌体在神经系统疾病中的研究进展[J].神经损伤与功能重建,2022(10).
Dongdong Ti,Haojie Hao,Xiaobing Fu,Weidong Han.Mesenchymal stem cells-derived exosomal microRNAs contribute to wound inflammation[J].Science China(Life Sciences),2016(12).
Liao Qing,Li Bao Jian,Li Yang,Xiao Yu,Zeng Hui,Liu Jie Mei,Yuan Li Xia,Liu Gang.Low-intensity pulsed ultrasound promotes osteoarthritic cartilage regeneration by BMSC-derived exosomes via modulating the NF-κB signaling pathway[J].International Immunopharmacology,2021.
Mijin Kim,Dong Il Shin,Byung Hyune Choi,Byoung-Hyun Min.Exosomes from IL-1β-Primed Mesenchymal Stem Cells Inhibited IL-1β- and TNF-α-Mediated Inflammatory Responses in Osteoarthritic SW982 Cells[J].Tissue Engineering and Regenerative Medicine,2021.
Rui Wang,Bin Xu.TGF-β1-modified MSC-derived exosomal miR-135b attenuates cartilage injury via promoting M2 synovial macrophage polarization by targeting MAPK6[J].Cell and Tissue Research,2021(prep).
Xia Peng,Wang Xinwei,Wang Qi,Wang Xiaoju,Lin Qiang,Cheng Kai,Li Xueping.Low-Intensity Pulsed Ultrasound Promotes Autophagy-Mediated Migration of Mesenchymal Stem Cells and Cartilage Repair.[J].Cell transplantation,2021.
Taghiyar Leila,Jahangir Shahrbano,Khozaei Ravari Mojtaba,Shamekhi Mohammad Amin,Eslaminejad Mohamadreza Baghaban.Cartilage Repair by Mesenchymal Stem Cell-Derived Exosomes: Preclinical and Clinical Trial Update and Perspectives.[J].Advances in experimental medicine and biology,2021.
Fazaeli Hoda,Kalhor Naser,Naserpour Leila,Davoodi Faezeh,Sheykhhasan Mohsen,Hosseini Seyed Kamal Eshagh,Rabiei Mohammad,Sheikholeslami Azar.A Comparative Study on the Effect of Exosomes Secreted by Mesenchymal Stem Cells Derived from Adipose and Bone Marrow Tissues in the Treatment of Osteoarthritis-Induced Mouse Model.[J].BioMed research international,2021.
Zhirong Wang,Kai Yan,Gaoran Ge,Di Zhang,Jiaxiang Bai,Xiaobin Guo,Jing Zhou,Tianpeng Xu,Menglei Xu,Xiao Long,Yuefeng Hao,Dechun Geng.Exosomes derived from miR-155-5p-overexpressing synovial mesenchymal stem cells prevent osteoarthritis via enhancing proliferation and migration, attenuating apoptosis, and modulating extracellular matrix secretion in chondrocytes.[J].Cell biology and toxicology,2020.
Li Zheng,Li Manling,Xu Peng,Ma Jie,Zhang Rui.Compositional Variation and Functional Mechanism of Exosomes in the Articular Microenvironment in Knee Osteoarthritis[J].Cell Transplantation,2020.
aff > .LncRNA MM2P-induced, exosome-mediated transfer of Sox9 from monocyte-derived cells modulates primary chondrocytes.[J].Cell death & disease,2020.
Qiu Bo,Xu Xiongfeng,Yi Peng,Hao Yarong.Curcumin reinforces MSC-derived exosomes in attenuating osteoarthritis via modulating the miR-124/NF-kB and miR-143/ROCK1/TLR9 signalling pathways.[J].Journal of cellular and molecular medicine,2020.
He Lei,He Tianwei,Xing Jianghao,Zhou Qing,Fan Lei,Liu Can,Chen Yuyong,Wu Depeng,Tian Zhenming,Liu Bin,Rong Limin.Bone marrow mesenchymal stem cell-derived exosomes protect cartilage damage and relieve knee osteoarthritis pain in a rat model of osteoarthritis.[J].Stem cell research & therapy,2020.
Jin Zhe,Ren Jiaan,Qi Shanlun.Exosomal miR-9-5p secreted by bone marrow-derived mesenchymal stem cells alleviates osteoarthritis by inhibiting syndecan-1.[J].Cell and tissue research,2020.
Wang Jian,Guo Xuanxuan,Kang Zhanrong,Qi Lingbin,Yang Ying,Wang Juan,Xu Jun,Gao Shane.Roles of Exosomes from Mesenchymal Stem Cells in Treating Osteoarthritis.[J].Cellular reprogramming,2020.
Tan Sharon Si Heng,Tjio Calvin Kai En,Wong Joshua Rui Yen,Wong Keng Lin,Chew Jacob Ren Jie,Hui James Hoi Po,Toh Wei Seong.Mesenchymal Stem Cell Exosomes for Cartilage Regeneration: A Systematic Review of Preclinical In Vivo Studies.[J].Tissue engineering. Part B, Reviews,2020.
Institute of Biomedical & Pharmaceutical Technology, Fuzhou University, Fuzhou 350002, PR China.,Institute of Biomedical & Pharmaceutical Technology, Fuzhou University, Fuzhou 350002, PR China.,College of Agriculture, Fujian Agriculture and Forestry University, Fuzhou 350002, PR China.,Institute of Biomedical & Pharmaceutical Technology, Fuzhou University, Fuzhou 350002, PR China.,Institute of Biomedical & Pharmaceutical Technology, Fuzhou University, Fuzhou 350002, PR China.,Institute of Biomedical & Pharmaceutical Technology, Fuzhou University, Fuzhou 350002, PR China..Kartogenin enhances the therapeutic effect of bone marrow mesenchymal stem cells derived exosomes in cartilage repair.[J].Nanomedicine (London, England),2020.
Parate Dinesh,Kadir Nurul Dinah,Celik Cenk,Lee Eng Hin,Hui James H P,Franco-Obregón Alfredo,Yang Zheng.Pulsed electromagnetic fields potentiate the paracrine function of mesenchymal stem cells for cartilage regeneration.[J].Stem cell research & therapy,2020.
Kolasinski Sharon L,Neogi Tuhina,Hochberg Marc C,Oatis Carol,Guyatt Gordon,Block Joel,Callahan Leigh,Copenhaver Cindy,Dodge Carole,Felson David,Gellar Kathleen,Harvey William F,Hawker Gillian,Herzig Edward,Kwoh C Kent,Nelson Amanda E,Samuels Jonathan,Scanzello Carla,White Daniel,Wise Barton,Altman Roy D,DiRenzo Dana,Fontanarosa Joann,Giradi Gina,Ishimori Mariko,Misra Devyani,Shah Amit Aakash,Shmagel Anna K,Thoma Louise M,Turgunbaev Marat,Turner Amy S,Reston James.2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee.[J].Arthritis care & research,2020.
Zhe Jin,Jiaan Ren,Shanlun Qi.Human bone mesenchymal stem cells-derived exosomes overexpressing microRNA-26a-5p alleviate osteoarthritis via down-regulation of PTGS2[J].International Immunopharmacology,2020.
Wang Yingjie,Shen Songpo,Li Zeng,Li Weifeng,Weng Xisheng.MIR-140-5p affects chondrocyte proliferation, apoptosis, and inflammation by targeting HMGB1 in osteoarthritis.[J].Inflammation research : official journal of the European Histamine Research Society ... [et al.],2020.
School of Health and Life Sciences, University of the West of Scotland, Paisley Campus, Paisley, UK.,School of Health and Life Sciences, University of the West of Scotland, Paisley Campus, Paisley, UK.,School of Health and Life Sciences, University of the West of Scotland, Paisley Campus, Paisley, UK.,Institute of Infection, Immunity and Inflammation, GBRC, University Place, University of Glasgow, Glasgow, UK.,School of Health and Life Sciences, University of the West of Scotland, Paisley Campus, Paisley, UK..Exosomes in intercellular communication and implications for osteoarthritis.[J].Rheumatology (Oxford, England),2020.
Zhu Zhongyi,Zhang Yijing,Wu Ligang,Hua Keqin,Ding Jingxin.Regeneration-Related Functional Cargoes in Mesenchymal Stem Cell-Derived Small Extracellular Vesicles.[J].Stem cells and development,2020.
Yuanyuan Che,Xu Shi,Yunpeng Shi,Xiaoming Jiang,Qing Ai,Ying Shi,Fengyan Gong,Wenyan Jiang.Exosomes Derived from miR-143-Overexpressing MSCs Inhibit Cell Migration and Invasion in Human Prostate Cancer by Downregulating TFF3[J].Molecular Therapy - Nucleic Acids,2019.
Desktop-stereolithography 3D printing of a radially oriented extracellular matrix/mesenchymal stem cell exosome bioink for osteochondral defect regeneration[J].Theranostics,2019.
Fathollahi Anwar,Aslani Saeed,Jamshidi Ahmadreza,Mahmoudi Mahdi.Epigenetics in osteoarthritis: Novel spotlight.[J].Journal of cellular physiology,2019.
Xiaorong Fu,Ge Liu,Alexander Halim,Yang Ju,Qing Luo,Guanbin Song.Mesenchymal Stem Cell Migration and Tissue Repair[J].Cells,2019.
Center for Joint Surgery, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, China.,Center of Bone Metabolism and Repair (CBMR), Trauma Center State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, China.,Center for Joint Surgery, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, China.,Center for Joint Surgery, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, China.,Center for Joint Surgery, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, China.,Center for Joint Surgery, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, China.,Center for Joint Surgery, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, China.,Department of Orthopedics, Hunan Provincial People's Hospital (the First Affiliated Hospital of Hunan Normal University), Changsha, 410005, China.,Center for Joint Surgery, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, China.,Department of Orthopedics, Hunan Provincial People's Hospital (the First Affiliated Hospital of Hunan Normal University), Changsha, 410005, China.,Department of Orthopedics, Hunan Provincial People's Hospital (the First Affiliated Hospital of Hunan Normal University), Changsha, 410005, China.,Center of Bone Metabolism and Repair (CBMR), Trauma Center State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, China. Electronic address: nizhenhong1986@163.com.,Center of Bone Metabolism and Repair (CBMR), Trauma Center State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, China. Electronic address: linchen70@163.com.,Center for Joint Surgery, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, China. Electronic address: jointsurgery@163.com..miR-100-5p-abundant exosomes derived from infrapatellar fat pad MSCs protect articular cartilage and ameliorate gait abnormalities via inhibition of mTOR in osteoarthritis[J].Biomaterials,2019.
Jianghong Huang,Yujie Liang,Zhiwang Huang,Pengchao Zhao,Qian Liang,Yonglong Liu,Li Duan,Wei Liu,Feiyan Zhu,Liming Bian,Jiang Xia,Jianyi Xiong,Daping Wang.Magnetic Enhancement of Chondrogenic Differentiation of Mesenchymal Stem Cells[J].ACS Biomater. Sci. Eng.,2019.
Shipin Zhang,Kristeen Ye Wen Teo,Shang Jiunn Chuah,Ruenn Chai Lai,Sai Kiang Lim,Wei Seong Toh.MSC exosomes alleviate temporomandibular joint osteoarthritis by attenuating inflammation and restoring matrix homeostasis[J].Biomaterials,2019.
Qi Hui,Liu Dan-Ping,Xiao Da-Wei,Tian Da-Chuan,Su Yong-Wei,Jin Shao-Feng.Exosomes derived from mesenchymal stem cells inhibit mitochondrial dysfunction-induced apoptosis of chondrocytes via p38, ERK, and Akt pathways.[J].In vitro cellular & developmental biology. Animal,2019.
Xie Jinwei,Huang Zeyu,Yu Xijie,Zhou Li,Pei Fuxing.Clinical implications of macrophage dysfunction in the development of osteoarthritis of the knee[J].Cytokine and Growth Factor Reviews,2019.
Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, PR China.,Key Laboratory of Musculoskeletal System Degeneration & Regeneration Translational Research of Zhejiang Province, Hangzhou, PR China.,Department of Orthopedics, 5th Affiliated Hospital, Lishui Municipal Central Hospital, Wenzhou Medical University, Lishui, PR China.,Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, PR China.,Key Laboratory of Musculoskeletal System Degeneration & Regeneration Translational Research of Zhejiang Province, Hangzhou, PR China.,Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, PR China.,Key Laboratory of Musculoskeletal System Degeneration & Regeneration Translational Research of Zhejiang Province, Hangzhou, PR China.,Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, PR China.,Key Laboratory of Musculoskeletal System Degeneration & Regeneration Translational Research of Zhejiang Province, Hangzhou, PR China.,Hangzhou Foreign Languages School, Hangzhou, PR China.,Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, PR China.,Key Laboratory of Musculoskeletal System Degeneration & Regeneration Translational Research of Zhejiang Province, Hangzhou, PR China.,Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, PR China.,Key Laboratory of Musculoskeletal System Degeneration & Regeneration Translational Research of Zhejiang Province, Hangzhou, PR China.,Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, PR China.,Key Laboratory of Musculoskeletal System Degeneration & Regeneration Translational Research of Zhejiang Province, Hangzhou, PR China.,Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, PR China.,Key Laboratory of Musculoskeletal System Degeneration & Regeneration Translational Research of Zhejiang Province, Hangzhou, PR China.,Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, PR China.,Key Laboratory of Musculoskeletal System Degeneration & Regeneration Translational Research of Zhejiang Province, Hangzhou, PR China.,Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, PR China.,Key Laboratory of Musculoskeletal System Degeneration & Regeneration Translational Research of Zhejiang Province, Hangzhou, PR China.,Department of Orthopedics, 5th Affiliated Hospital, Lishui Municipal Central Hospital, Wenzhou Medical University, Lishui, PR China.,Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, PR China.,Key Laboratory of Musculoskeletal System Degeneration & Regeneration Translational Research of Zhejiang Province, Hangzhou, PR China.,Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, PR China.,Key Laboratory of Musculoskeletal System Degeneration & Regeneration Translational Research of Zhejiang Province, Hangzhou, PR China..Primary chondrocyte exosomes mediate osteoarthritis progression by regulating mitochondrion and immune reactivity.[J].Nanomedicine (London, England),2019.
Wang Rui,Xu Bin,Xu Honggang.TGF-β1 promoted chondrocyte proliferation by regulating Sp1 through MSC-exosomes derived miR-135b.[J].Cell cycle (Georgetown, Tex.),2018(24).
Terence W. O'Neill,Paul S. McCabe,John McBeth.Update on the epidemiology, risk factors and disease outcomes of osteoarthritis[J].Best Practice & Research Clinical Rheumatology,2018.
Oishi Yumiko,Manabe Ichiro.Macrophages in inflammation, repair and regeneration.[J].International immunology,2018.
Liu Yubao,Zou Rui,Wang Zhen,Wen Chuanyang,Zhang Fan,Lin Fuqing.Exosomal KLF3-AS1 from hMSCs promoted cartilage repair and chondrocyte proliferation in osteoarthritis.[J].The Biochemical journal,2018.
Mao Guping,Zhang Ziji,Hu Shu,Zhang Zhiqi,Chang Zongkun,Huang Zhiyu,Liao Weiming,Kang Yan.Exosomes derived from miR-92a-3p-overexpressing human mesenchymal stem cells enhance chondrogenesis and suppress cartilage degradation via targeting WNT5A.[J].Stem cell research & therapy,2018.
Alessandra Bortoluzzi,Federica Furini,Carlo A. Scirè.Osteoarthritis and its management - Epidemiology, nutritional aspects and environmental factors[J].Autoimmunity Reviews,2018.
Meng Fangang,Li Zhiwen,Zhang Zhiqi,Yang Zibo,Kang Yan,Zhao Xiaoyi,Long Dianbo,Hu Shu,Gu Minghui,He Suiwen,Wu Peihui,Chang Zongkun,He Aishan,Liao Weiming.MicroRNA-193b-3p regulates chondrogenesis and chondrocyte metabolism by targeting HDAC3.[J].Theranostics,2018.
Farshid Guilak,Robert J. Nims,Amanda Dicks,Chia-Lung Wu,Ingrid Meulenbelt.Osteoarthritis as a disease of the cartilage pericellular matrix[J].Matrix Biology,2018.
Department of Radiology, Chonnam National University Medical School, Chonnam National University Hwasun Hospital, Hwasun 58128, Biomolecular Theranostics (BiT) Lab, South Korea,Department of Bionanosystem Engineering, Graduate School, Chonbuk National University, Jeonju 561-756, Republic of Korea,Division of Mechanical Design Engineering, Chonbuk National University, Jeonju 561-756, Republic of Korea,Department of Radiology, Chonnam National University Medical School, Chonnam National University Hwasun Hospital, Hwasun 58128, Biomolecular Theranostics (BiT) Lab, South Korea,Department of Radiology, Chonnam National University Medical School, Chonnam National University Hwasun Hospital, Hwasun 58128, Biomolecular Theranostics (BiT) Lab, South Korea,Department of Bionanosystem Engineering, Graduate School, Chonbuk National University, Jeonju 561-756, Republic of Korea,Department of Bionanosystem Engineering, Graduate School, Chonbuk National University, Jeonju 561-756, Republic of Korea,Division of Mechanical Design Engineering, Chonbuk National University, Jeonju 561-756, Republic of Korea,Department of Bionanosystem Engineering, Graduate School, Chonbuk National University, Jeonju 561-756, Republic of Korea,Division of Mechanical Design Engineering, Chonbuk National University, Jeonju 561-756, Republic of Korea,Department of Radiology, Chonnam National University Medical School, Chonnam National University Hwasun Hospital, Hwasun 58128, Biomolecular Theranostics (BiT) Lab, South Korea.Electromagnetic manipulation enabled calcium alginate Janus microsphere for targeted delivery of mesenchymal stem cells[J].International Journal of Biological Macromolecules,2018.
a Department of Orthopaedics , Luhe People's Hospital of Nanjing , Nanjing , China.,a Department of Orthopaedics , Luhe People's Hospital of Nanjing , Nanjing , China.,a Department of Orthopaedics , Luhe People's Hospital of Nanjing , Nanjing , China.,a Department of Orthopaedics , Luhe People's Hospital of Nanjing , Nanjing , China.,a Department of Orthopaedics , Luhe People's Hospital of Nanjing , Nanjing , China.,a Department of Orthopaedics , Luhe People's Hospital of Nanjing , Nanjing , China..MSC-derived exosomes promote proliferation and inhibit apoptosis of chondrocytes via lncRNA-KLF3-AS1/miR-206/GIT1 axis in osteoarthritis.[J].Cell cycle (Georgetown, Tex.),2018.
Vina Ernest R,Kwoh C Kent.Epidemiology of osteoarthritis: literature update.[J].Current opinion in rheumatology,2018.
Keshtkar Somayeh,Azarpira Negar,Ghahremani Mohammad Hossein.Mesenchymal stem cell-derived extracellular vesicles: novel frontiers in regenerative medicine.[J].Stem cell research & therapy,2018.
Zhang Hao,Li Zhong-Li,Yang Fei,Zhang Qiang,Su Xiang-Zheng,Li Ji,Zhang Ning,Liu Chun-Hui,Mao Ning,Zhu Heng.Radial shockwave treatment promotes human mesenchymal stem cell self-renewal and enhances cartilage healing.[J].Stem cell research & therapy,2018.
Min-Huan Wu,Chun-Hao Tsai,Yuan-Li Huang,Yi-Chin Fong,Chih-Hsin Tang.Visfatin Promotes IL-6 and TNF-α Production in Human Synovial Fibroblasts by Repressing miR-199a-5p through ERK, p38 and JNK Signaling Pathways[J].International Journal of Molecular Sciences,2018.
Hui Li,Shi-Bing Guan,Yi Lu,Fei Wang.MiR-140-5p inhibits synovial fibroblasts proliferation and inflammatory cytokines secretion through targeting TLR4[J].Biomedicine & Pharmacotherapy,2017.
Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model[J].Theranostics,2017.
Lin Sien,Lee Wayne Yuk Wai,Feng Qian,Xu Liangliang,Wang Bin,Man Gene Chi Wai,Chen Yuanfeng,Jiang Xiaohua,Bian Liming,Cui Liao,Wei Bo,Li Gang.Synergistic effects on mesenchymal stem cell-based cartilage regeneration by chondrogenic preconditioning and mechanical stimulation.[J].Stem cell research & therapy,2017.
Wang Yulan,Hu Xiaoxia,Dai Jing,Wang Jie,Tan Yaning,Yang Xiangdong,Yang Shuang,Yuan Quan,Zhang Yufeng.A 3D graphene coated bioglass scaffold for bone defect therapy based on the molecular targeting approach.[J].Journal of materials chemistry. B,2017.
Chen Lei,Yang Wenjin,Guo Yijun,Chen Wei,Zheng Ping,Zeng Jinsong,Tong Wusong.Exosomal lncRNA GAS5 regulates the apoptosis of macrophages and vascular endothelial cells in atherosclerosis.[J].PloS one,2017.
Parate Dinesh,Franco-Obregón Alfredo,Fröhlich Jürg,Beyer Christian,Abbas Azlina A,Kamarul Tunku,Hui James H P,Yang Zheng.Enhancement of mesenchymal stem cell chondrogenesis with short-term low intensity pulsed electromagnetic fields.[J].Scientific reports,2017.
Wang Yafei,Yu Dongsheng,Liu Zhiming,Zhou Fang,Dai Jun,Wu Bingbing,Zhou Jing,Heng Boon Chin,Zou Xiao Hui,Ouyang Hongwei,Liu Hua.Exosomes from embryonic mesenchymal stem cells alleviate osteoarthritis through balancing synthesis and degradation of cartilage extracellular matrix.[J].Stem cell research & therapy,2017.
Shi Weili,Sun Muyang,Hu Xiaoqing,Ren Bo,Cheng Jin,Li Chenxi,Duan Xiaoning,Fu Xin,Zhang Jiying,Chen Haifeng,Ao Yingfang.Structurally and Functionally Optimized Silk-Fibroin-Gelatin Scaffold Using 3D Printing to Repair Cartilage Injury In Vitro and In Vivo.[J].Advanced materials (Deerfield Beach, Fla.),2017.
Wei Seong Toh,Ruenn Chai Lai,James Hoi Po Hui,Sai Kiang Lim.MSC exosome as a cell-free MSC therapy for cartilage regeneration: Implications for osteoarthritis treatment[J].Seminars in Cell and Developmental Biology,2017.
Peng-Fei Ma,Chun-Chen Gao,Jing Yi,Jun-Long Zhao,Shi-Qian Liang,Yang Zhao,Yu-Chen Ye,Jian Bai,Qi-Jun Zheng,Ke-Feng Dou,Hua Han,Hong-Yan Qin.Cytotherapy with M1-polarized macrophages ameliorates liver fibrosis by modulating immune microenvironment in mice[J].Journal of Hepatology,2017.
Phinney Donald G,Pittenger Mark F.Concise Review: MSC-Derived Exosomes for Cell-Free Therapy.[J].Stem cells (Dayton, Ohio),2017.
Hu Xiaoxia,Wang Yulan,Tan Yaning,Wang Jie,Liu Haoyang,Wang Yingqian,Yang Shuang,Shi Miusi,Zhao Shiyong,Zhang Yufeng,Yuan Quan.A Difunctional Regeneration Scaffold for Knee Repair based on Aptamer-Directed Cell Recruitment.[J].Advanced materials (Deerfield Beach, Fla.),2017.
Shoki Yamaguchi,Tomoki Aoyama,Akira Ito,Momoko Nagai,Hirotaka Iijima,Junichi Tajino,Xiangkai Zhang,Kiyan Wataru,Hiroshi Kuroki.Effect of Low-Intensity Pulsed Ultrasound after Mesenchymal Stromal Cell Injection to Treat Osteochondral Defects: An In Vivo Study[J].Ultrasound in Medicine & Biology,2016.
Martel-Pelletier Johanne,Barr Andrew J,Cicuttini Flavia M,Conaghan Philip G,Cooper Cyrus,Goldring Mary B,Goldring Steven R,Jones Graeme,Teichtahl Andrew J,Pelletier Jean-Pierre.Osteoarthritis.[J].Nature reviews. Disease primers,2016.
Luz-Crawford Patricia,Djouad Farida,Toupet Karine,Bony Claire,Franquesa Marcella,Hoogduijn Martin J,Jorgensen Christian,Noël Danièle.Mesenchymal Stem Cell-Derived Interleukin 1 Receptor Antagonist Promotes Macrophage Polarization and Inhibits B Cell Differentiation.[J].Stem cells (Dayton, Ohio),2016.
Zafar Rasheed,Hani A. Al-Shobaili,Naila Rasheed,Amer Mahmood,Mohammed Imran Khan.MicroRNA-26a-5p regulates the expression of inducible nitric oxide synthase via activation of NF-κB pathway in human osteoarthritis chondrocytes[J].Archives of Biochemistry and Biophysics,2016.
Pengfei Chen,Jiadong Tao,Shouan Zhu,Youzhi Cai,Qijiang Mao,Dongsheng Yu,Jun Dai,HongWei Ouyang.Radially oriented collagen scaffold with SDF-1 promotes osteochondral repair by facilitating cell homing[J].Biomaterials,2015.
Wei Zhang,Jialin Chen,Jiadong Tao,Yangzi Jiang,Changchang Hu,Lu Huang,Junfeng Ji,Hong Wei Ouyang.The use of type 1 collagen scaffold containing stromal cell-derived factor-1 to create a matrix environment conducive to partial-thickness cartilage defects repair[J].Biomaterials,2013.
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