1. 山东第一医科大学,济南
2. 上海市养志康复医院,上海
3. 山东第一医科大学附属省立医院影像科,济南
纸质出版:2025
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李未, 赵阳, 王光彬, 等. 小脑高频重复经颅磁刺激对吞咽神经网络影响的功能性磁共振成像观察[J]. 中华物理医学与康复杂志, 2025,(5):398-402.
李未, 赵阳, 王光彬, et al. 小脑高频重复经颅磁刺激对吞咽神经网络影响的功能性磁共振成像观察[J]. 2025, (5): 398-402.
目的基于功能性磁共振成像技术(fMRI)观察高频重复经颅磁刺激(rTMS)左侧小脑半球对吞咽神经网络的影响。方法共招募健康志愿者30例
采用10 Hz rTMS对其左侧小脑半球进行刺激
于磁刺激前、后对所有受试者进行fMRI检查。观察干预前、后受试者下颌舌骨肌运动诱发电位(MEP)波幅以及静息态fMRI数据(ALFF、fALFF、ReHo)变化。结果受试者左侧小脑半球经高频rTMS干预后
发现其双侧下颌舌骨肌MEP波幅均显著增加
差异均具有统计学意义(P<0.001);干预后受试者左侧小脑区域、枕叶、前额叶、楔叶以及中央前回、中央后回等区域的低频波动振幅(ALFF)、分数低频波动振幅(fALFF)均较干预前显著增加
差异均具有统计学意义(P<0.05);另外左侧小脑、枕叶、顶叶、右侧中央前回及中央后回区域的局部一致性(ReHo)水平亦较干预前显著增加
差异均具有统计学意义(P<0.05)。结论 10 Hz rTMS刺激左侧小脑半球能明显提高双侧半球吞咽皮质核束的兴奋性
同时中央前回、中央后回、枕叶、楔叶、颞叶、顶下回、右侧前运动皮质、右侧前额叶背外侧皮质等脑区的神经活动亦显著增强
提示小脑组织在吞咽神经网络中发挥重要作用。
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