Multidisciplinary Comprehensive Diagnosis and Treatment of Sinonasal Adenoid Cystic Carcinoma

ZHEN Hongtao

doi:10.3971/j.issn.1000-8578.2026.25.0775

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Multidisciplinary Comprehensive Diagnosis and Treatment of Sinonasal Adenoid Cystic Carcinoma

更新时间：2026-11-05

- Multidisciplinary Comprehensive Diagnosis and Treatment of Sinonasal Adenoid Cystic Carcinoma
- Vol. 53, Issue 4, Pages: 237-242(2026)
- 作者机构：
- 作者简介：
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- DOI：10.3971/j.issn.1000-8578.2026.25.0775
  CLC： R739.62
- Published：2026
- 稿件说明：
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甄宏韬. 鼻腔鼻窦腺样囊性癌的多学科综合诊治[J]. 肿瘤防治研究, 2026, 53(4): 237-242.

ZHEN Hongtao. Multidisciplinary Comprehensive Diagnosis and Treatment of Sinonasal Adenoid Cystic Carcinoma[J]. 2026, 53(4): 237-242.
甄宏韬. 鼻腔鼻窦腺样囊性癌的多学科综合诊治[J]. 肿瘤防治研究, 2026, 53(4): 237-242. DOI： 10.3971/j.issn.1000-8578.2026.25.0775.

ZHEN Hongtao. Multidisciplinary Comprehensive Diagnosis and Treatment of Sinonasal Adenoid Cystic Carcinoma[J]. 2026, 53(4): 237-242. DOI： 10.3971/j.issn.1000-8578.2026.25.0775.

摘要

鼻腔鼻窦腺样囊性癌（SNACC）是除鳞状细胞癌外，发病率占第二位的鼻腔鼻窦恶性肿瘤。大多数患者在诊断时已处于疾病晚期阶段（T3~T4），伴有较高比例的神经浸润、骨浸润和前颅底受累，手术切缘阳性率高。治疗后易出现局部复发和远处转移，甚至可能发生在初次治疗后数年或数十年。影像学检查对于明确肿瘤范围具有重要价值，但确诊仍需组织活检。手术切除是SNACC目前主要的治疗方式，其中经鼻内镜手术在降低并发症和改善生活质量方面具有优势，其生存结局与开放手术相当。对于不可切除的患者，推荐采用放疗联合或不联合化疗方案。长期密切随访对于该病的全程管理十分必要。MDT能为SNACC的诊治提供核心策略。MDT模式强调精准分期与个体化治疗，通过整合各学科优势，旨在实现肿瘤控制、功能保留和生活质量改善的统一，是目前管理SNACC的最佳途径。

Abstract

Sinonasal adenoid cystic carcinoma (SNACC) is the second most common sinonasal malignancy

following squamous cell carcinoma. Most patients present with advanced stage disease (T3-T4) at the time of diagnosis

with a propensity for perineural invasion

bone invasion

anterior skull base involvement

and high probability of positive margins. After initial treatment

local recurrence and distant metastasis are common

sometimes occurring years later. Imaging studies are valuable for determining the extent of the tumor

but a pathological biopsy remains essential for a definitive diagnosis. Surgical resection is currently the primary treatment modality. Endoscopic surgery offers advantages in reducing complications and improving quality of life while providing comparable survival outcomes to open surgery. For unresectable cases

radiotherapy combined with or without chemotherapy is recommended. Long-term close follow-up is crucial for comprehensive management of the disease. A multidisciplinary team (MDT) provides the core strategy for the diagnosis and treatment of SNACC. The MDT focuses on precise staging and personalized treatment

aiming to balance tumor control

functional preservation

and quality of life improvement. It represents the optimal current management pathway for SNACC.

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references

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