VEGF Inhibitor–Associated Side Effects in Antitumor Therapy and Intervention Strategies

LIU Lu; SUN Wanting; YAO Shuning; CHEN Zhenyu; WANG Yuefei; YANG Jing

doi:10.3971/j.issn.1000-8578.2026.25.0759

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VEGF Inhibitor–Associated Side Effects in Antitumor Therapy and Intervention Strategies

更新时间：2026-11-05

- VEGF Inhibitor–Associated Side Effects in Antitumor Therapy and Intervention Strategies
- Vol. 53, Issue 4, Pages: 289-300(2026)
- 作者机构：
  
  1. 天津中医药大学中医药研究院，现代中药创制全国重点实验室,天津,301617
  2. 天津中医药大学中药学院,天津,301617
  3. 现代中医药海河实验室,天津,301617
- 作者简介：
- 基金信息：
- DOI：10.3971/j.issn.1000-8578.2026.25.0759
  CLC： R730
- Published：2026
- 稿件说明：
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刘璐, 孙婉婷, 姚舒宁, 陈珍雨, 王跃飞, 杨静. VEGF抑制剂的抗肿瘤相关常见不良反应及其干预策略[J]. 肿瘤防治研究, 2026, 53(4): 289-300.

LIU Lu, SUN Wanting, YAO Shuning, et al. VEGF Inhibitor–Associated Side Effects in Antitumor Therapy and Intervention Strategies[J]. 2026, 53(4): 289-300.
刘璐, 孙婉婷, 姚舒宁, 陈珍雨, 王跃飞, 杨静. VEGF抑制剂的抗肿瘤相关常见不良反应及其干预策略[J]. 肿瘤防治研究, 2026, 53(4): 289-300. DOI： 10.3971/j.issn.1000-8578.2026.25.0759.

LIU Lu, SUN Wanting, YAO Shuning, et al. VEGF Inhibitor–Associated Side Effects in Antitumor Therapy and Intervention Strategies[J]. 2026, 53(4): 289-300. DOI： 10.3971/j.issn.1000-8578.2026.25.0759.

摘要

血管内皮生长因子（VEGF）抑制剂是一类靶向抑制肿瘤血管生成的药物，通过阻断VEGF及其受体的信号通路来抑制肿瘤增殖，在肿瘤治疗中发挥了重要作用。然而，其治疗过程中的相关不良反应严重影响患者治疗依从性和生存质量，甚至导致治疗中断。因此探索VEGF抑制剂不良反应的干预策略对肿瘤治疗具有重要意义。本文就VEGF抑制剂在肿瘤治疗过程中导致的高血压、蛋白尿、手足皮肤反应和骨髓抑制等常见不良反应的临床特征和毒性机制等展开综述，并总结了针对性的中西医结合干预策略。精准监测、调整药物剂量以达到抗肿瘤的目的，采用益气活血、健脾补肾等中药针对性地改善患者不适症状，中西药协同救治患者，为肿瘤患者提供更安全有效的治疗方案。

Abstract

Vascular endothelial growth factor (VEGF) inhibitors are drugs that target and inhibit tumor angiogenesis. By blocking the signaling pathway of VEGF and its receptor

they suppress tumor proliferation and play a crucial role in tumor treatment. However

their side effects

such as hypertension

proteinuria

hand-foot skin reactions

and myelosuppression

during treatment seriously affect patients' treatment compliance and quality of life. The development of intervention strategies for the side effects of VEGF inhibitors is of great importance for tumor treatment. This article reviews the clinical characteristics and toxic mechanisms of common side effects caused by VEGF inhibitors during tumor treatment and summarizes intervention strategies that combine traditional Chinese and Western medicines. Drug dosages were precisely monitored and adjusted to achieve antitumor treatment. Patients' discomfort symptoms are improved through prescriptions that act by tonifying qi and promoting blood circulation

strengthening the spleen

and tonifying the kidney. The combination of traditional Chinese and Western medicines is used to treat patients

thus providing a safe and effective treatment plan for patients with cancer.

关键词

Keywords

references

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