Factors Affecting Survival of 4892 Patients with Colorectal Cancer in Yunnan Province

CAI Ruiqi; YANG Zhijian; YANG Yanyan; MA Guoyu; PANG Yuying; ZHANG Mengjiao; LUO Lei; LI Sile; ZHAO Min

doi:10.3971/j.issn.1000-8578.2026.25.0751

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Factors Affecting Survival of 4892 Patients with Colorectal Cancer in Yunnan Province

更新时间：2026-11-05

- Factors Affecting Survival of 4892 Patients with Colorectal Cancer in Yunnan Province
- Vol. 53, Issue 4, Pages: 274-280(2026)
- 作者机构：
  
  1. 昆明医科大学第三附属医院，云南省肿瘤医院，北京大学肿瘤医院云南医院肿瘤防治办公室,昆明,650118
  2. 昆明医科大学第三附属医院，云南省肿瘤医院，北京大学肿瘤医院云南医院感染管理科,昆明,650118
  3. 昆明医科大学第三附属医院，云南省肿瘤医院，北京大学肿瘤医院云南医院门诊部,昆明,650118
  4. 昆明医科大学第三附属医院，云南省肿瘤医院，北京大学肿瘤医院云南医院医务部,昆明,650118
- 作者简介：
- 基金信息：
- DOI：10.3971/j.issn.1000-8578.2026.25.0751
  CLC： R735.3
- Published：2026
- 稿件说明：
移动端阅览
蔡瑞琪, 杨志坚, 杨颜颜, 马国玉, 庞钰莹, 张梦娇, 罗镭, 李四乐, 赵敏. 云南省4892例结直肠癌患者生存的影响因素分析[J]. 肿瘤防治研究, 2026, 53(4): 274-280.

CAI Ruiqi, YANG Zhijian, YANG Yanyan, et al. Factors Affecting Survival of 4892 Patients with Colorectal Cancer in Yunnan Province[J]. 2026, 53(4): 274-280.
蔡瑞琪, 杨志坚, 杨颜颜, 马国玉, 庞钰莹, 张梦娇, 罗镭, 李四乐, 赵敏. 云南省4892例结直肠癌患者生存的影响因素分析[J]. 肿瘤防治研究, 2026, 53(4): 274-280. DOI： 10.3971/j.issn.1000-8578.2026.25.0751.

CAI Ruiqi, YANG Zhijian, YANG Yanyan, et al. Factors Affecting Survival of 4892 Patients with Colorectal Cancer in Yunnan Province[J]. 2026, 53(4): 274-280. DOI： 10.3971/j.issn.1000-8578.2026.25.0751.

摘要

目的

分析云南省结直肠癌患者的生存状况及其影响因素。

方法

回顾性收集

4892

例结直肠癌患者的临床资料。通过随访获取生存数据，采用Kaplan-Meier法计算总生存率（OS），Log-rank检验进行单因素分析，Cox比例风险回归模型进行多因素分析。

结果

全组患者的1、3、5、10年OS率分别为91.90%、74.40%、64.40%和28.70%。单因素分析结果显示，年龄、民族、地区、分化程度、TNM分期、临床分期、转移状态、组织学类型及治疗方式（化疗、放疗、手术）与患者预后相关（均

0.05）。多因素分析结果显示，年龄（

=1.250）、地区（

=1.262）、分化程度（

=0.761）、临床分期（

=3.128）及治疗方式（化疗：

=0.644、放疗：

=1.605、手术：

=0.384）是影响结直肠癌患者生存预后的独立因素（均

0.001）。

结论

年龄、地区、临床分期和治疗方式是云南省结直肠癌患者生存的独立影响因素。临床实践中应结合这些因素制订个体化的防治策略，以期改善患者预后。

Abstract

Objective

To analyze survival outcomes and influencing factors among patients with colorectal cancer in Yunnan Province.

Methods

Clinical data were retrospectively collected from 4 892 patients with colorectal cancer. Survival data were obtained through follow-

up. Overall survival (OS) was calculated by using the Kaplan-Meier method. Univariate analysis was performed by applying the log-rank test. Meanwhile

multivariate analysis employed the Cox proportional hazards regression model.

Results

The 1-

and 10-year OS rates for the entire cohort were 91.90%

74.40%

64.40%

and 28.70%

respectively. Univariate analysis revealed that age

ethnicity

region

differentiation grade

TNM stage

clinical stage

metastatic status

histological type

and treatment modality (chemotherapy

radiotherapy

and surgery) were associated with patient prognosis (all

0.05). Multivariate analysis identified age (

=1.250)

region (

=1.262)

differentiation grade (

=0.761)

clinical stage (

=3.128)

and treatment modality (chemotherapy

=0.644; radiotherapy

=1.605; surgery

=0.384) as independent factors affecting survival prognosis in patients with colorectal cancer (all

0.001).

Conclusion

Age

region

clinical stage

and treatment modality are independent factors influencing survival among patients with colorectal cancer in Yunnan Province. In clinical practice

these factors should be integrated to develop individualized prevention and treatment strategies

thereby improving patient outcomes.

关键词

Keywords

references

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