Correlation between cardiorespiratory fitness and lower limb muscle strength in patients undergoing maintenance hemodialysis and its effect on peak oxygen uptake

Liu Sha-sha; Yang Wen-jun; Maihaitijiang Dilinuer; Ma Yi-rong

doi:10.3969/j.issn.1671-2390.2026.10.005

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Correlation between cardiorespiratory fitness and lower limb muscle strength in patients undergoing maintenance hemodialysis and its effect on peak oxygen uptake

Clinical Study | 更新时间：2026-10-21

- Correlation between cardiorespiratory fitness and lower limb muscle strength in patients undergoing maintenance hemodialysis and its effect on peak oxygen uptake
- Journal of Clinical Nephrology Vol. 26, Issue 10, Pages: 933-939(2026)
- 作者机构：
  
  新疆医科大学第一附属医院肾病科，乌鲁木齐 830000
- 作者简介：
  
  Yang Wen-jun， Email： 455123651@qq.com
- 基金信息：
  
  "Tianshan Talents" High-level Talent Training Program for Medical and Health Care(TSYC202301B051)
- DOI：10.3969/j.issn.1671-2390.2026.10.005
  CLC：
- Received：12 November 2025，
  
  Published：28 October 2026
- 稿件说明：
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刘沙沙,杨文君,迪丽努尔·麦海提江等.维持性血液透析患者心肺适能与下肢肌力的相关性及其对峰值摄氧量的影响研究[J].临床肾脏病杂志,2026,26(10):933-939.

Liu Sha-sha,Yang Wen-jun,Dilinuer Maihaitijiang,et al.Correlation between cardiorespiratory fitness and lower limb muscle strength in patients undergoing maintenance hemodialysis and its effect on peak oxygen uptake[J].Journal of Clinical Nephrology,2026,26(10):933-939.
刘沙沙,杨文君,迪丽努尔·麦海提江等.维持性血液透析患者心肺适能与下肢肌力的相关性及其对峰值摄氧量的影响研究[J].临床肾脏病杂志,2026,26(10):933-939. DOI： 10.3969/j.issn.1671-2390.2026.10.005.

Liu Sha-sha,Yang Wen-jun,Dilinuer Maihaitijiang,et al.Correlation between cardiorespiratory fitness and lower limb muscle strength in patients undergoing maintenance hemodialysis and its effect on peak oxygen uptake[J].Journal of Clinical Nephrology,2026,26(10):933-939. DOI： 10.3969/j.issn.1671-2390.2026.10.005.

摘要

目的

探究维持性血液透析患者心肺适能（cardiorespiratory fitness，CRF）与下肢肌力的相关性，以及影响峰值摄氧量的独立因素。

方法

采用单中心回顾性分析，选取新疆医科大学第一附属医院肾病科2024年1月至2025年1月期间收治的330例维持性血液透析患者为研究对象，作为患病组，并匹配326名同期健康人群作为健康组。通过心肺运动测试评估CRF，伸膝力量测量量化下肢肌力，结合6 min步行距离测试反映运动耐力。比较两组受试者各指标差异，并运用多元线性回归分析，深入探究影响维持性血液透析患者峰值摄氧量的关键因素。

结果

患病组患者在关键体能指标上均显著劣于健康组：峰值摄氧量［（14.33±2.68）mL·kg

-1

·min

-1

比（21.36±2.76）mL·kg

-1

·min

-1

］、伸膝力量［（26.65±3.69）kg 比（43.49±5.65）kg］及6 min步行距离［（419.65±37.98）m比（533.32±24.56）m］均较低，而计时起立行走试验（timed up and go test，TUGT）时间［（12.39±2.98）s比（8.95±2.45）s］更长（

均

0.05）。相关性分析显示，峰值摄氧量与伸膝力量、6 min步行距离呈正相关（

=0.631、0.589，

0.05），与TUGT呈负相关（

=-0.613，

0.05）。多元线性回归进一步证实，年龄、肌肉量减少及肌力减退是影响峰值摄氧量的独立危险因素（

0.05），且变量间无显著共线性（

VIF

均

5）。

结论

维持性血液透析患者CRF与下肢肌力密切相关，年龄增长、肌肉量减少及肌力减退是影响峰值摄氧量的关键因素。通过针对性干预下肢肌力，可有效提升峰值摄氧量，进而改善患者运动耐力与生活质量，对优化临床康复策略具有重要指导价值。

Abstract

Objective

To investigate the correlation between cardiorespiratory fitness （CRF） and lower limb muscle strength in patients undergoing maintenance hemodialysis， and to identify the independent factors affecting peak oxygen uptake.

Methods

A single-center retrospective analysis was conducted. A total of 330 patients undergoing maintenance hemodialysis who were admitted to the Department of Nephrology of the First Affiliated Hospital of Xinjiang Medical University from January 2024 to January 2025 were selected as the disease group， and 326 matched healthy individuals from the same period were included as the healthy group. CRF was assessed by cardiopulmonary exercise testing， lower limb muscle strength was quantified by knee extension strength measurement， and exercise endurance was reflected by the 6-minute walk distance test. Differences in each indicator were compared between the two groups， and multivariate linear regression analysis was used to further explore the key factors affecting peak oxygen uptake in patients undergoing maintenance hemodialysis.

Results

Compared with the healthy group， patients in the disease group showed significantly poorer performance in key physical fitness indicators： peak oxygen uptake （［14.33±2.68］ mL·kg

-1

·min

-1

［21.36±2.76］ mL·kg

-1

·min

-1

）， knee extension strength （［26.65±3.69］ kg

［43.49±5.65］ kg）， and 6-minute walk distance （［419.65±37.98］ m

［533.32±24.56］ m） were all lower， whereas the timed up and go test （TUGT） time （［12.39±2.98］ s

［8.95±2.45］ s） was longer （all

0.05）. Correlation analysis showed that peak oxygen uptake was positively correlated with knee extension strength and 6-minute walk distance （

=0.631， 0.589；

0.05）， and negatively correlated with TUGT （

=-0.613，

0.05）. Multivariate linear regression further confirmed that age， reduced muscle mass， and decreased muscle strength were independent risk factors affecting peak oxygen uptake （

0.05）， and there was no significan

t collinearity among variables （all

VIF

5）.

Conclusion

CRF is closely associated with lower limb muscle strength in patients undergoing maintenance hemodialysis. Advancing age， reduced muscle mass， and decreased muscle strength are key factors affecting peak oxygen uptake. Targeted intervention to improve lower limb muscle strength can effectively increase peak oxygen uptake， thereby improving exercise endurance and quality of life， and may provide important guidance for optimizing clinical rehabilitation strategies.

关键词

Keywords

references

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