Spontaneous rupture in hepatocellular carcinoma： a discussion on key issues

Xia Feng; Zhang Bixiang; Zhu Peng

doi:10.3969/j.issn.1003-5591.2025.01.001

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Spontaneous rupture in hepatocellular carcinoma： a discussion on key issues

更新时间：2026-11-05

- Spontaneous rupture in hepatocellular carcinoma： a discussion on key issues
- J Abdominal Surg Vol. 38, Issue 1, Pages: 1-6(2025)
- 作者机构：
  
  华中科技大学同济医学院附属同济医院肝脏外科，湖北武汉 430030
- 作者简介：
  
  Zhu Peng，Email：zhupeng@tjh.tjmu.edu.cn
- 基金信息：
- DOI：10.3969/j.issn.1003-5591.2025.01.001
  CLC： R657.3;R735.7
- Received：03 February 2025，
  
  Published：22 February 2025
- 稿件说明：
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夏丰,张必翔,朱鹏.肝细胞癌自发性破裂的相关问题探讨[J].腹部外科,2025,38(01):1-6.

Xia Feng,Zhang Bixiang,Zhu Peng.Spontaneous rupture in hepatocellular carcinoma： a discussion on key issues[J].J Abdominal Surg,2025,38(01):1-6.
夏丰,张必翔,朱鹏.肝细胞癌自发性破裂的相关问题探讨[J].腹部外科,2025,38(01):1-6. DOI： 10.3969/j.issn.1003-5591.2025.01.001.

Xia Feng,Zhang Bixiang,Zhu Peng.Spontaneous rupture in hepatocellular carcinoma： a discussion on key issues[J].J Abdominal Surg,2025,38(01):1-6. DOI： 10.3969/j.issn.1003-5591.2025.01.001.

摘要

肝细胞癌（hepatocellular carcinoma，HCC）自发性破裂是HCC病人中一种危及生命的急性并发症，临床表现为自发性肿瘤破裂及腹腔内出血。尽管TNM分期系统将其归类为T

期，但针对性的治疗策略可显著改善病人的生存预后。此文综合分析了HCC自发性破裂的流行病学特征、危险因素、病理生理机制以及多种治疗方式的效果差异。重点探讨了破裂相关因素、围手术期管理策略及术后预后预测模型的应用，旨在为临床治疗提供循证依据。此外，还结合近年来的研究进展，讨论重新定义该疾病分期的重要性，以期优化诊疗策略，提升病人生存率和生活质量，并综合华中科技大学同济医学院附属同济医院肝脏中心既往经验得出同济经验。

Abstract

Spontaneous rupture of hepatocellular carcinoma（HCC） is a life-threatening acute complication in HCC patients，clinically manifested as spontaneous tumor rupture and intra-abdominal hemorrhage.Although classified in T

by the TNM staging system，targeted treatment strategies can significantly improve the survival prognosis of spontaneous rupture of HCC.This review comprehensively analyzed the epidemiological characteristics，risk factors，pathophysiological mechanisms，and the efficacy differences of various treatment modalities for spontaneous rupture of HCC.It focused on the timing of surgery，perioperative management strategies，and the application of postoperative prognostic prediction models，aiming to provide evidence-based guidance for clinical treatment.Additionally，by integrating recent research advancements，we discussed the importance of redefining the staging of spontaneous rupture of HCC to optimize diagnostic and therapeutic strategies，thereby improving the survival and quality of life.The review also incorporated the previous experience of our center to present the clinical experience in managing spontaneous rupture of HCC at Liver Center，Tongji Hospital，Tongji Medical College of Huazhong University of Science and Technology.

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references

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