Values of fibrinogen and interleukin-6 in assessing the severity of acute cholecystitis

Ruan Xiaoxiao

doi:10.3969/j.issn.1003-5591.2024.04.010

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Values of fibrinogen and interleukin-6 in assessing the severity of acute cholecystitis

更新时间：2026-11-05

- Values of fibrinogen and interleukin-6 in assessing the severity of acute cholecystitis
- J Abdominal Surg Vol. 37, Issue 4, Pages: 287-289(2024)
- 作者机构：
  
  徐州市铜山区人民医院普通外科，江苏徐州 221000
- 作者简介：
  
  Ruan Xiaoxiao， Email： rxxdoctor@163.com
- 基金信息：
- DOI：10.3969/j.issn.1003-5591.2024.04.010
  CLC： R604
- Published：22 August 2024
- 稿件说明：
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阮晓晓.纤维蛋白原和白细胞介素-6对急性胆囊炎严重程度的评估价值[J].腹部外科,2024,37(04):287-289.

Ruan Xiaoxiao.Values of fibrinogen and interleukin-6 in assessing the severity of acute cholecystitis[J].J Abdominal Surg,2024,37(04):287-289.
阮晓晓.纤维蛋白原和白细胞介素-6对急性胆囊炎严重程度的评估价值[J].腹部外科,2024,37(04):287-289. DOI： 10.3969/j.issn.1003-5591.2024.04.010.

Ruan Xiaoxiao.Values of fibrinogen and interleukin-6 in assessing the severity of acute cholecystitis[J].J Abdominal Surg,2024,37(04):287-289. DOI： 10.3969/j.issn.1003-5591.2024.04.010.

摘要

目的

探讨纤维蛋白原（fibrinogen，FIB）及白细胞介素-6（interleukin-6，IL-6）对急性胆囊炎严重程度的评估价值。

方法

选取徐州铜山区人民医院普外科2021年10月至2023年10月期间所收治的165例起病在72 h以内的急性胆囊炎病人作为研究对象。根据胆囊炎严重程度分为轻度胆囊炎组78例和中重度胆囊炎组87例，分别检测两组病人FIB和IL-6水平，并建立受试者操作特征（ROC）曲线评价两个指标对急性胆囊炎严重程度的评估价值。

结果

中重度胆囊炎组病人FIB、IL-6水平均明显高于轻度胆囊炎组，组间比较差异具有统计学意义（

＜0.05）。ROC曲线显示：利用FIB预测的曲线下面积（AUC）为0.760，最佳诊断点为3.455 g/L，其敏感度为85.1%，特异度为55.1%；利用IL-6预测的AUC为0.752，最佳诊断点为83.365 ng/L，其敏感度为48.3%，特异性为100%。FIB和IL-6两者联合预测急性胆囊炎严重程度的AUC为0.845，显著高于两者单

独预测的AUC；其敏感度为67.8%，特异性为84.6%。

结论

中重度胆囊炎病人的FIB和IL-6水平均明显升高，二者对判断急性胆囊炎严重程度有较高的评估价值，且二者联合评估价值更佳。

Abstract

Objective

To explore the values of fibrinogen （FIB） and interleukin-6 （IL-6） in assessing the severity of acute cholecystitis （AC）.

Methods

From October 2021 to October 2023， 165 AC patients within 72 hours of onset were recruited. According to the severity of AC， they were assigned into two groups of mild cholecystitis （

=78） and moderate/severe cholecystitis （

=87）. The levels of FIB and IL-6 were detected and receiver operating characteristic （ROC） curves plotted for assessing the value of FIB/IL-6 for the severity of AC.

Results

The levels of FIB and IL-6 were significantly higher in moderate/severe cholecystitis group than those in mild cholecystitis group. And the inter-group difference was statistically significant （

0.05）. ROC curve indicated that area under the curve （AUC） predicted by FIB was 0.760. The optimal diagnostic point was 3.455 g/L with a sensitivity of 85.1% and a specificity of 55.1%. And AUC predicted by IL-6 was 0.752. The optimal diagnostic point was 83.365 pg/ml with a sensitivity of 48.3% and a specificity of 100%. AUC of FIB plus IL-6 in predicting the severity of AC was 0.845. It was significantly higher than AUC predicted by each alone. The sensitivity was 67.8% and the specificity 84.6%.

Conclusion

The levels of FIB and IL-6 spike markedly in moderate/severe cholecystitis. Both parameters have higher values in judging the severity of AC. And a combination of both is even better.

关键词

Keywords

references

Alhazmi A ， de Carvalho Fischer C ， Schaafs LA ， et al . Epiploic appendagitis：an uncommon and nonsurgical cause of abdominal pain ［J］. Chirurgie ， 2023 ， 94 （ 11 ）： 954 - 958 . DOI： 10.1007/s00104-023-01960-4 http://dx.doi.org/10.1007/s00104-023-01960-4 .

朱彩鹏，何敏，巢凯，等 . 急性胆囊炎并发胆囊穿孔的临床特征及诊疗分析［J］. 中国临床研究， 2021 ， 34 （ 7 ）： 913 - 917 . DOI： 10.13429/j.cnki.cjcr.2021.07.011 http://dx.doi.org/10.13429/j.cnki.cjcr.2021.07.011 .

Gamal-Eldeen AM ， Fahmy CA ， Raafat BM ， et al . Circulating levels of hypoxia-regulating microRNAs in systemic lupus erythematosus patients with hemolytic anemia ［J］. Curr Med Sci ， 2022 ， 42 （ 6 ）： 1231 - 1239 . DOI： 10.1007/s11596-022-2644-y http://dx.doi.org/10.1007/s11596-022-2644-y .

Calabrese . How can interleukin-I antagonists be developed to treat skin diseases？［J］. Br J Dermatol ， 2022 ， 186 （ 6 ）： e263 . DOI： 10.1111/bjd.21304 http://dx.doi.org/10.1111/bjd.21304 .

曾伟，张弦，熊涛，等 . 血清纤维蛋白原水平在卒中相关感染中的诊断价值［J］. 临床合理用药杂志， 2019 ， 12 （ 29 ）： 5 - 6，9 . DOI： 10.15887/j.cnki.13-1389/r.2019.29.003 http://dx.doi.org/10.15887/j.cnki.13-1389/r.2019.29.003 .

Nagasawa H ， Omori K ， Nojiri S ， et al . The fibrin/fibrinogen degradation product level on arrival in trauma patients is a better predictor of a fatal outcome than physiological or anatomical severity：a retrospective chart review ［J］. Trauma ， 2022 ， 24 （ 1 ）： 43 - 50 . DOI： 10.1177/1460408620975704 http://dx.doi.org/10.1177/1460408620975704 .

George S ， Wake E ， Jansen M ， et al . Fibrinogen Early in Severe paediatric Trauma studY （FEISTY junior）：protocol for a randomised controlled trial ［J］. BMJ Open ， 2022 ， 12 （ 5 ）： e057780 . DOI： 10.1136/bmjopen-2021-057780 http://dx.doi.org/10.1136/bmjopen-2021-057780 .

Jin RM ， Huang HZ ， Zhou Y ， et al . Characterization of mandarin fish （Siniperca chuatsi） IL-6 and IL-6 signal transducer and the association between their SNPs and resistance to ISKNV disease ［J］. Fish Shellfish Immunol ， 2021 ， 113 ： 139 - 147 . DOI： 10.1016/j.fsi.2021.04.003 http://dx.doi.org/10.1016/j.fsi.2021.04.003 .

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