Research progress on post‑translational modifications of proteins in cardiovascular diseases

CHEN Zhe; LI Fei

doi:10.14188/j.1671-8852.2026.0103

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Research progress on post‑translational modifications of proteins in cardiovascular diseases

更新时间：2026-11-05

- Research progress on post‑translational modifications of proteins in cardiovascular diseases
- Medical Journal of Wuhan University Vol. 47, Issue 10, Pages: 1415-1420(2026)
- 作者机构：
  
  华中科技大学同济医学院附属协和医院心血管外科湖北武汉 430022
- 作者简介：
- 基金信息：
- DOI：10.14188/j.1671-8852.2026.0103
  CLC： R541
- Received：29 January 2026，
  
  Published：25 October 2026
- 稿件说明：
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陈哲,李飞.蛋白质翻译后修饰在心血管疾病中的研究进展[J].武汉大学学报（医学版）,2026,47(10):1415-1420.

CHEN Zhe,LI Fei.Research progress on post‑translational modifications of proteins in cardiovascular diseases[J].Medical Journal of Wuhan University,2026,47(10):1415-1420.
陈哲,李飞.蛋白质翻译后修饰在心血管疾病中的研究进展[J].武汉大学学报（医学版）,2026,47(10):1415-1420. DOI： 10.14188/j.1671-8852.2026.0103.

CHEN Zhe,LI Fei.Research progress on post‑translational modifications of proteins in cardiovascular diseases[J].Medical Journal of Wuhan University,2026,47(10):1415-1420. DOI： 10.14188/j.1671-8852.2026.0103.

摘要

蛋白质翻译后修饰（PTM）是蛋白质合成后通过共价连接功能基团调控结构与功能的关键机制，其动态平衡与心血管系统稳态维持密切相关。本文系统综述了传统修饰（磷酸化、乙酰化等）与新兴酰化修饰（琥珀酰化、乳酸化等）在动脉粥样硬化、心肌梗死、高血压、心力衰竭等心血管疾病（CVD）中的作用机制，并总结靶向PTM的临床转化潜力与研究瓶颈，为CVD的精准诊断与治疗提供新思路。

Abstract

Post⁃translational modifications (PTMs) are key mechanisms that regulate protein structure and function through the covalent attachment of functional groups after protein synthesis. Their dynamic balance is closely linked to the maintenance of cardiovascular homeostasis. This review systematically summarizes the roles and mechanisms of both classical PTMs (e.g.

phosphorylation and acetylation) and emerging acylation modifications (e.g.

succinylation and lactylation) in various cardiovascular diseases (CVDs)

such as atherosclerosis

myocardial infarction

hypertension

and heart failure. It further summarizes the translational potential of targeting PTMs as therapeutic targets in clinical practice

addresses current research bottlenecks

and aims to provide new insights into the precise diagnosis and treatment of cardiovascular diseases.

关键词

Keywords

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