Short‑term efficacy and safety of transcatheter edge‑to‑edge repair: A single⁃center retrospective analysis

TAN Ge; XIONG Lecai; CHEN Xing; WANG Yi; LIU Jinping; ZHANG Li

doi:10.14188/j.1671-8852.2025.1383

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Short‑term efficacy and safety of transcatheter edge‑to‑edge repair: A single⁃center retrospective analysis

更新时间：2026-11-05

- Short‑term efficacy and safety of transcatheter edge‑to‑edge repair: A single⁃center retrospective analysis
- Medical Journal of Wuhan University Vol. 47, Issue 10, Pages: 1391-1398(2026)
- 作者机构：
  
  武汉大学中南医院心血管外科湖北武汉 430071
- 作者简介：
- 基金信息：
- DOI：10.14188/j.1671-8852.2025.1383
  CLC： R654.2
- Received：18 November 2025，
  
  Published：25 October 2026
- 稿件说明：
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谭戈,熊乐财,陈星等.经导管缘对缘修复术短期疗效与安全性的单中心回顾性分析[J].武汉大学学报（医学版）,2026,47(10):1391-1398.

TAN Ge,XIONG Lecai,CHEN Xing,et al.Short‑term efficacy and safety of transcatheter edge‑to‑edge repair: A single⁃center retrospective analysis[J].Medical Journal of Wuhan University,2026,47(10):1391-1398.
谭戈,熊乐财,陈星等.经导管缘对缘修复术短期疗效与安全性的单中心回顾性分析[J].武汉大学学报（医学版）,2026,47(10):1391-1398. DOI： 10.14188/j.1671-8852.2025.1383.

TAN Ge,XIONG Lecai,CHEN Xing,et al.Short‑term efficacy and safety of transcatheter edge‑to‑edge repair: A single⁃center retrospective analysis[J].Medical Journal of Wuhan University,2026,47(10):1391-1398. DOI： 10.14188/j.1671-8852.2025.1383.

摘要

目的

评价经导管缘对缘修复术(TEER)对中度至重度二尖瓣反流(MR)患者的短期有效性及安全性。

方法

回顾性分析2022年4月至2025年8月在武汉大学中南医院心外科行TEER的二尖瓣反流患者的临床资料，包括术前基线临床及超声心动图资料、术中资料及术后1个月随访资料。

结果

共纳入49名患者（男性30例，女性19例），均完成1个月随访。主要疗效结局是30 d时MR≤2+；纽约心脏病协会(NYHA)心功能改善≥1级或6 min步行试验距离(6MWD)增加>50 m；安全性结局是术后30 d内新发生的主要不良心脑血管事件(MACCE)，定义为心血管相关性死亡、非致死性卒中、心肌梗死、心衰、瓣膜功能再障碍和肾功能障碍的复合。在手术的49名患者中，术后30 d复查二尖瓣反流≤2+者为100%；术后30 d内新发生的MACCE发生率为4.08%，全部因不稳定心绞痛、心衰而再次住院，无心血管死亡、卒中或心肌梗死事件发生。

结论

TEER可有效减少二尖瓣反流，并具有良好的短期安全性。

Abstract

Objective

To evaluate the short‑term safety and effectiveness of transcatheter edge‑to‑edge repair (TEER) in patients with moderate‑to‑severe mitral regurgitation (MR).

Methods

A retrospective analysis was conducted on clinical data from patients with moderate‑to‑severe MR who underwent TEER in the Department of Cardiovascular Surgery of Zhongnan Hospital of Wuhan University

between April 2022 and August 2025. Data were collected including pre‑operative clinical and echocardiographic parameters

intraoperative records

and 1‑month postoperative follow‑up information.

Results

A total of 49 patients (30 male

19 female) were enrolled

and all cases completed 1‑month follow‑up. The primary efficacy endpoint was MR grade ≤2+ at 30 days. Secondary efficacy outcomes included an improvement of ≥1 class in New York Heart Association (NYHA) functional classification or an increase of >50 meters in the 6‑minute walk test distance (6MWD). The safety endpoint was the occurrence of new‑onset major adverse cardiac and cerebrovascular events (MACCE) within 30 days post‑procedure

a composite of cardiovascular mortality

non‑fatal stroke

myocardial infarction

heart failure rehospitalization

valvular dysfunction

and renal dysfunction. Among the 49 patients

100% achieved MR grade ≤2+ at the 30‑day follow‑up. The 30‑day MACCE rate was 4.08%

with all events being rehospitalizations due to unstable angina or heart failure. No cardiovascular deaths

strokes

or myocardial infarctions occurred.

Conclusion

The results indicate that TEER effectively reduces mitral regurgitation and has a favorable short‑term safety profile.

关键词

Keywords

references

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