Predictive value of white blood cell to hemoglobin ratio for in‐hospital mortality risk in patients with heart failure

TU Pei; LIU Haizhen; TU Yanming; ZONG Wenxia; LI Chang

doi:10.14188/j.1671-8852.2025.0709

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Predictive value of white blood cell to hemoglobin ratio for in‐hospital mortality risk in patients with heart failure

更新时间：2026-11-05

- Predictive value of white blood cell to hemoglobin ratio for in‐hospital mortality risk in patients with heart failure
- Medical Journal of Wuhan University Vol. 46, Issue 11, Pages: 1463-1468(2025)
- 作者机构：
  
  江汉大学附属湖北省第三人民医院心血管内科湖北武汉 430033
- 作者简介：
- 基金信息：
- DOI：10.14188/j.1671-8852.2025.0709
  CLC： R541.6
- Received：02 July 2024，
  
  Published：25 November 2025
- 稿件说明：
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涂佩,刘海珍,涂焰明等.白细胞计数与血红蛋白比值对心力衰竭患者院内死亡风险的预测价值[J].武汉大学学报（医学版）,2025,46(11):1463-1468.

TU Pei,LIU Haizhen,TU Yanming,et al.Predictive value of white blood cell to hemoglobin ratio for in‐hospital mortality risk in patients with heart failure[J].Medical Journal of Wuhan University,2025,46(11):1463-1468.
涂佩,刘海珍,涂焰明等.白细胞计数与血红蛋白比值对心力衰竭患者院内死亡风险的预测价值[J].武汉大学学报（医学版）,2025,46(11):1463-1468. DOI： 10.14188/j.1671-8852.2025.0709.

TU Pei,LIU Haizhen,TU Yanming,et al.Predictive value of white blood cell to hemoglobin ratio for in‐hospital mortality risk in patients with heart failure[J].Medical Journal of Wuhan University,2025,46(11):1463-1468. DOI： 10.14188/j.1671-8852.2025.0709.

摘要

目的

探讨白细胞计数与血红蛋白比值（WHR）对心力衰竭（心衰）患者院内死亡的预测价值，并评估其作为预后标志物的临床应用潜力。

方法

采用回顾性队列研究，连续纳入2022年8月至2024年8月期间在江汉大学附属湖北省第三人民医院心血管内科住院治疗的心力衰竭患者，根据住院期间转归将患者分为存活组（

=202）和死亡组（

=50）。收集患者的一般资料及实验室指标，分析WHR对心力衰竭患者院内死亡风险的预测价值。

结果

WHR是心衰患者院内死亡的独立危险因素（

=1.95，95%

: 1.075~1.329，

0.001）。ROC分析显示，WHR对心衰患者院内死亡具有良好的预测价值（

AUC

=0.735 7，95%

: 0.658 1~0.813 4），最佳截断点为6.449 5（灵敏度68.0%，特异度70.3%）。Cox生存分析表明，高WHR患者死亡风险增加2.684倍（95%

: 2.010~6.752）。

结论

WHR是心衰患者院内死亡的独立预测因子，具有较高的临床预测价值，可作为早期风险评估和预后评估的可靠生物学标志物。该指标简便易得，有助于临床医生识别高危患者并优化干预策略。

Abstract

Objective

To investigate the predictive value of the white blood cell to hemoglobin ratio (WHR) for in‐hospital mortality in patients with heart failure (HF) and to assess its clinical application potential as a prognostic marker.

Methods

This study employed a retrospective cohort design

consecutively enrolling patients with heart failure admitted to the Department of Cardiology

The Third People's Hospital of Hubei Province Affiliated to Jianghan University from August 2022 to August 2024. Patients were divided into survival group (

=202) and mortality group (

=50) based on their outcomes during hospitalization. Demographics and laboratory parameters were collected

and statistical analysis was performed to assess the predictive value of WHR for in‐hospital mortality risk in HF patients.

Results

WHR was an independent risk factor for in‐hospital mortality in HF patients (

=1.95

95%

: 1.075⁃1.329

0.001). ROC analysis showed that WHR had good predictive value for in‐hospital mortality among heart failure patients (

AUC

=0.735 7

95%

: 0.658 1⁃0.813 4)

with an optimal cutoff point of 6.449 5 (sensitivity 68.0%

specificity 70.3%). Cox survival analysis indicated that patients with high WHR exhibited a 2.684‐fold increased risk of death (95%

: 2.010⁃6.752).

Conclusion

WHR is an independent predictor of in‐hospital mortality in HF patients

with high clinical predictive value

which could serve as a reliable biological marker for early risk assessment and prognosis evaluation. This readily accessible indicator facilitates early risk stratification and prognosis assessment

enabling clinicians to identify high⁃risk cases and optimize therapeutic strategies.

关键词

Keywords

references

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Related Author

TU Pei

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Related Institution

Dept. of Cardiology， Third People's Hospital of Hubei Province Affiliated to Jianghan University

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Department of Cardiology, Renmin Hospital of Wuhan University

Dept. of Cardiovascular Medicine， Zhongnan Hospital of Wuhan University

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