Lung metastatic renal clear cell carcinoma with sarcomatoid differentiation： Case report and literature review

ZHANG Qingling; ZHU Yali; XUAN Mengyao; CHAN Wenjia; CHEN Hang; CHEN Honglei

doi:10.14188/j.1671-8852.2025.0632

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Lung metastatic renal clear cell carcinoma with sarcomatoid differentiation： Case report and literature review

更新时间：2026-11-05

- Lung metastatic renal clear cell carcinoma with sarcomatoid differentiation： Case report and literature review
- Medical Journal of Wuhan University Vol. 46, Issue 11, Pages: 1449-1454(2025)
- 作者机构：
  
  1.武汉大学泰康医学院（基础医学院）病理学教研室湖北武汉 430071
  2.武汉大学中南医院肿瘤放疗中心湖北武汉 430071
  3.空军军医大学第二附属医院病理科陕西西安 710038
  4.武汉大学中南医院病理科湖北武汉 430071
- 作者简介：
- 基金信息：
- DOI：10.14188/j.1671-8852.2025.0632
  CLC： R737.11
- Received：19 June 2025，
  
  Published：25 November 2025
- 稿件说明：
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张庆玲,朱雅丽,轩梦瑶等.肺转移性肾透明细胞癌伴肉瘤样分化病例报告并文献复习[J].武汉大学学报（医学版）,2025,46(11):1449-1454.

ZHANG Qingling,ZHU Yali,XUAN Mengyao,et al.Lung metastatic renal clear cell carcinoma with sarcomatoid differentiation： Case report and literature review[J].Medical Journal of Wuhan University,2025,46(11):1449-1454.
张庆玲,朱雅丽,轩梦瑶等.肺转移性肾透明细胞癌伴肉瘤样分化病例报告并文献复习[J].武汉大学学报（医学版）,2025,46(11):1449-1454. DOI： 10.14188/j.1671-8852.2025.0632.

ZHANG Qingling,ZHU Yali,XUAN Mengyao,et al.Lung metastatic renal clear cell carcinoma with sarcomatoid differentiation： Case report and literature review[J].Medical Journal of Wuhan University,2025,46(11):1449-1454. DOI： 10.14188/j.1671-8852.2025.0632.

摘要

肾细胞癌伴肉瘤样分化（RCCS）在临床上极为罕见，发生远处转移者更是鲜有文献报道。该文报道一例因RCCS行右肾切除术的患者，术后5年出现肺转移。特别值得关注的是，该例肺转移灶的组织学显示其仅由肉瘤样分化成分构成，完全缺乏经典肾透明细胞癌形态学特征，这一形态学差异表现显著增加了其病理诊断的复杂性，极易误诊。鉴于该病例的挑战性与特殊性，结合相关文献，阐述了RCCS的临床表现、影像学特征和病理形态学特点，旨在提升对该病认识及诊断水平。

Abstract

Renal cell carcinoma with sarcomatoid differentiation (RCCS) is extremely rare in clinical practice

and there are few reports on distant metastasis. This article reports a patient who underwent right nephrectomy due to RCCS and developed lung metastasis five years later. Notably

the histology of the lung metastasis in this case showed that the metastases were solely composed of sarcomatoid differentiated components

and were completely lacking the classical morphological features of clear cell carcinoma

which significantly increases the complexity of pathological diagnosis and is prone to misdiagnosis. Given the challenges and uniqueness of this case

this article reviews the clinical manifestations

imaging characteristics

and pathological morphological features of RCCS based on the relevant literature

aiming to improve the understanding and diagnostic level of this disease.

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Keywords

references

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