Research advances of artificial liver in severe liver failure

YANG Yafei; NA Shufang; LIU Qiaoyun; YE Qifa

doi:10.14188/j.1671-8852.2025.0547

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Research advances of artificial liver in severe liver failure

更新时间：2026-11-05

- Research advances of artificial liver in severe liver failure
- Medical Journal of Wuhan University Vol. 47, Issue 10, Pages: 1405-1414(2026)
- 作者机构：
  
  1.武汉大学中南医院/武汉大学肝胆疾病研究院/武汉大学移植医学中心/移植医学技术湖北省重点实验室湖北武汉 430071
  2.中南大学湘雅三医院/国家卫生健康委移植医学转化研究重点实验室湖南长沙 410013
- 作者简介：
- 基金信息：
- DOI：10.14188/j.1671-8852.2025.0547
  CLC： R575.3
- Received：27 May 2025，
  
  Published：25 October 2026
- 稿件说明：
移动端阅览
杨娅菲,那淑芳,刘巧云等.人工肝在重症肝衰竭中的研究进展[J].武汉大学学报（医学版）,2026,47(10):1405-1414.

YANG Yafei,NA Shufang,LIU Qiaoyun,et al.Research advances of artificial liver in severe liver failure[J].Medical Journal of Wuhan University,2026,47(10):1405-1414.
杨娅菲,那淑芳,刘巧云等.人工肝在重症肝衰竭中的研究进展[J].武汉大学学报（医学版）,2026,47(10):1405-1414. DOI： 10.14188/j.1671-8852.2025.0547.

YANG Yafei,NA Shufang,LIU Qiaoyun,et al.Research advances of artificial liver in severe liver failure[J].Medical Journal of Wuhan University,2026,47(10):1405-1414. DOI： 10.14188/j.1671-8852.2025.0547.

摘要

肝衰竭是临床常见的严重肝病症候群，尤以急性和慢加急性肝衰竭进展迅猛，短期死亡率高。为提高患者移植等待期生存率、改善相关症状，人工肝治疗作为一种有效的桥接治疗方法被深入研究。非生物型人工肝已广泛应用于临床，依据不同模式的运行机制及靶向清除的物质，临床可实施个体化治疗方案。生物型人工肝的核心优势在于部分替代肝细胞的生理功能，目前在细胞来源及生物反应器构建方面已开展大量研究，部分成果已进入临床试验阶段。混合型人工肝整合两类人工肝技术优势，在优化疗效及推动临床转化方面展现潜力。该文系统综述了国内外非生物型、生物型及混合型人工肝技术的研究进展，对其进行总结与探讨，旨在为人工肝的临床应用及研究方向提供参考。

Abstract

Liver failure is a common clinical syndrome of severe liver disease

particularly acute and acute‑on‑chronic liver failure

which are characterized by rapid progression and high short‑term mortality. Artificial liver support therapy has been intensively studied as an effective bridge treatment

with the objective of improving the survival rate and alleviating symptoms during transplant waiting periods. Non‑biological artificial livers have been widely implemented in clinical practice

enabling individualized treatment protocols based on the operational mechanisms of different modalities and the substances targeted for removal. Biological artificial livers

with their core advantage of partially substituting hepatic physiological functions

have undergone extensive research in cell sources and bioreactor construction

with some results advancing to clinical trial stages. Hybrid artificial livers integrate the advantages of non‑biological and biological systems

showing potential in optimizing therapeutic efficacy and promoting clinical translation. This article systematically reviews the research advancements in non‑biological

biological

and hybrid artificial liver technologies worldwide

summarizes their key findings

and discusses future directions

aiming to provide references for clinical applications and research in artificial liver therapy.

关键词

Keywords

references

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