Infection susceptibility and its physiological mechanisms in diabetic patients

ZHANG Jinjin; TANG Jun; PAN An

doi:10.14188/j.1671-8852.2025.0054

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Infection susceptibility and its physiological mechanisms in diabetic patients

更新时间：2026-11-05

- Infection susceptibility and its physiological mechanisms in diabetic patients
- Medical Journal of Wuhan University Vol. 46, Issue 11, Pages: 1506-1512(2025)
- 作者机构：
  
  1.华中科技大学同济医学院公共卫生学院湖北武汉　430030
  2.武汉大学中南医院，过敏反应科，湖北武汉 430071
  3.武汉大学中南医院，内分泌科，湖北武汉 430071
- 作者简介：
- 基金信息：
- DOI：10.14188/j.1671-8852.2025.0054
  CLC： R587.1
- Received：14 January 2025，
  
  Published：25 November 2025
- 稿件说明：
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张珒珒,唐俊,潘安.糖尿病患者的感染易感性及其生理学机制[J].武汉大学学报（医学版）,2025,46(11):1506-1512.

ZHANG Jinjin,TANG Jun,PAN An.Infection susceptibility and its physiological mechanisms in diabetic patients[J].Medical Journal of Wuhan University,2025,46(11):1506-1512.
张珒珒,唐俊,潘安.糖尿病患者的感染易感性及其生理学机制[J].武汉大学学报（医学版）,2025,46(11):1506-1512. DOI： 10.14188/j.1671-8852.2025.0054.

ZHANG Jinjin,TANG Jun,PAN An.Infection susceptibility and its physiological mechanisms in diabetic patients[J].Medical Journal of Wuhan University,2025,46(11):1506-1512. DOI： 10.14188/j.1671-8852.2025.0054.

摘要

近年来，糖尿病与感染之间的双向关系已成为临床和公共卫生关注的焦点。糖尿病患者因免疫功能受损、高血糖状态以及血管和神经系统并发症，显著增加了感染的易感性和严重程度。同时，感染通过诱发炎症反应和代谢紊乱进一步加剧了糖尿病的进展和血糖失控。该文综述了糖尿病与感染风险增高的机制及流行病学特点，分析了糖尿病人群患感染性疾病的发病趋势变化，并强调了血糖控制对降低感染相关住院和死亡风险的重要性。通过揭示这些机制和特征，该文旨在为糖尿病患者的感染性疾病防控提供科学依据和实践指导。

Abstract

In recent years

the bidirectional relationship between diabetes and infections has become a focal point of clinical and public health interest. Diabetic patients experience significantly increased susceptibility to infections and greater severity due to immune dysfunction

hyperglycemic state

and vascular and neurological complications. In addition

infections exacerbate diabetes progression and glycemic dysregulation by triggering inflammatory responses and metabolic disturbances. This review explores the mechanisms underlying the increased risk of infections in diabetes and the associated epidemiological characteristics

analyzes the trends in infectious disease incidence among diabetes populations

and highlights the critical role of glycemic control in reducing infection‑related hospitalizations and mortality. By elucidating these mechanisms and characteristics

this study aims to provide a scientific foundation and practical guidance for the prevention and management of infectious diseases in diabetic patients.

关键词

Keywords

references

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