Research progress on the ratio of soluble fms like tyrosine kinase 1 to placental growth factor for predicting preeclampsia

LEI Yin; SHA Menghan; YIN Heng; CHEN Xiangyi; ZHAO Yun

doi:10.14188/j.1671-8852.2024.0956

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Research progress on the ratio of soluble fms like tyrosine kinase 1 to placental growth factor for predicting preeclampsia

更新时间：2026-11-05

- Research progress on the ratio of soluble fms like tyrosine kinase 1 to placental growth factor for predicting preeclampsia
- Medical Journal of Wuhan University Vol. 46, Issue 9, Pages: 1203-1210(2025)
- 作者机构：
  
  1.武汉科技大学医学部医学院湖北武汉 430065
  2.湖北省妇幼保健院产科湖北武汉 430070
- 作者简介：
- 基金信息：
- DOI：10.14188/j.1671-8852.2024.0956
  CLC： R714.25
- Received：10 December 2024，
  
  Published：26 September 2025
- 稿件说明：
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雷银,沙梦晗,尹恒等.可溶性fms样酪氨酸激酶1与胎盘生长因子比值用于预测子痫前期的研究进展[J].武汉大学学报（医学版）,2025,46(09):1203-1210.

LEI Yin,SHA Menghan,YIN Heng,et al.Research progress on the ratio of soluble fms like tyrosine kinase 1 to placental growth factor for predicting preeclampsia[J].Medical Journal of Wuhan University,2025,46(09):1203-1210.
雷银,沙梦晗,尹恒等.可溶性fms样酪氨酸激酶1与胎盘生长因子比值用于预测子痫前期的研究进展[J].武汉大学学报（医学版）,2025,46(09):1203-1210. DOI： 10.14188/j.1671-8852.2024.0956.

LEI Yin,SHA Menghan,YIN Heng,et al.Research progress on the ratio of soluble fms like tyrosine kinase 1 to placental growth factor for predicting preeclampsia[J].Medical Journal of Wuhan University,2025,46(09):1203-1210. DOI： 10.14188/j.1671-8852.2024.0956.

摘要

子痫前期（PE）是妊娠并发症之一，涉及母体多系统，与母儿的发病率密切相关。目前PE发病机制仍不明确，治疗手段有限，因此，预测PE以便及时采取相应防治措施成为关注的重点。尽管诸多文献已对可溶性fms样酪氨酸激酶1（sFlt⁃1）与胎盘生长因子（PLGF）预测PE进行研究和总结，但目前此比值预测和排除PE的具体标准尚未形成共识。通过查阅、梳理相关文献，本文系统介绍了PE与sFlt⁃1、PLGF及其比值相关的作用机制，总结了不同妊娠时期sFlt⁃1/PLGF预测PE发生、进展及结局的研究成果，以期为PE的预测及风险评估提供一定的参考价值和证据支持。

Abstract

Preeclampsia (PE) is one of the complications of pregnancy

which induces multisystemic maternal dysfunction and is strongly associated with adverse maternal and perinatal outcomes. At present

the pathogenesis of PE is still unclear and the treatment methods are limited. Therefore

predicting PE in order to take corresponding prevention and treatment measures in a timely manner has become a focus of attention for doctors. Although many literature have studied and summarized the relationship between soluble fms like tyrosine kinase 1 (sFlt⁃1) and placental growth factor (PLGF) in predicting PE

there is currently no consensus on the specific criteria for predicting and excluding PE using this ratio. By reviewing and organizing relevant literature

this review systematically introduces the mechanisms linking PE to sFlt⁃1

PLGF

and their ratios. It summarizes the research results on predicting the occurrence

progression

and outcome of PE with sFlt⁃1/PLGF at different stages of pregnancy

in order to provide certain reference value and evidence support for the prediction and risk assessment of PE.

关键词

Keywords

references

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