Analysis of risk factors for synchronous brain metastasis in stage T1 lung adenocarcinoma

GUO Yang; DU Chunxian; LONG Yun; GAN Tian; LI Ting; ZHANG Kemeng; LIAO Meiyan

doi:10.14188/j.1671-8852.2024.0756

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Analysis of risk factors for synchronous brain metastasis in stage T1 lung adenocarcinoma

更新时间：2026-11-05

- Analysis of risk factors for synchronous brain metastasis in stage T1 lung adenocarcinoma
- Medical Journal of Wuhan University Vol. 46, Issue 11, Pages: 1436-1440(2025)
- 作者机构：
  
  1.武汉大学中南医院，医学影像科，湖北武汉 430071
  2.武汉大学中南医院，呼吸与危重症医学科，湖北武汉 430071
- 作者简介：
- 基金信息：
- DOI：10.14188/j.1671-8852.2024.0756
  CLC： R445.3
- Received：02 October 2024，
  
  Published：25 November 2025
- 稿件说明：
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郭杨,杜春仙,龙云等.T1期肺腺癌同步脑转移危险因素分析[J].武汉大学学报（医学版）,2025,46(11):1436-1440.

GUO Yang,DU Chunxian,LONG Yun,et al.Analysis of risk factors for synchronous brain metastasis in stage T1 lung adenocarcinoma[J].Medical Journal of Wuhan University,2025,46(11):1436-1440.
郭杨,杜春仙,龙云等.T1期肺腺癌同步脑转移危险因素分析[J].武汉大学学报（医学版）,2025,46(11):1436-1440. DOI： 10.14188/j.1671-8852.2024.0756.

GUO Yang,DU Chunxian,LONG Yun,et al.Analysis of risk factors for synchronous brain metastasis in stage T1 lung adenocarcinoma[J].Medical Journal of Wuhan University,2025,46(11):1436-1440. DOI： 10.14188/j.1671-8852.2024.0756.

摘要

目的

探讨T1期肺腺癌同步脑转移的危险因素。

方法

回顾性分析2017年8月至2023年10月武汉大学中南医院肺腺癌病例资料，筛选T1期肺腺癌同步脑转移病例，根据肿瘤最大径使用倾向性匹配（PSM）T1期无脑转移病例作为对照组，比较两组病例临床信息及CT影像学资料，使用多因素Logistic回归分析筛选T1期肺腺癌同步脑转移的危险因素。

结果

45例T1期肺腺癌同步脑转移病例纳入研究，PSM匹配对照组45例，单因素分析显示两组间结节‑脊柱距离、血管集束征、表皮生长因子（EGFR）突变状态、血清癌胚抗原（CEA）差异有统计学意义(

0.05)；多因素Logistic回归分析提示EGFR突变状态、CEA是T1期肺腺癌同步脑转移的独立危险因素(

0.05)。

结论

T1期肺腺癌EGFR突变、血清CEA升高是同步脑转移的独立危险因素。

Abstract

Objective

To identify the risk factors for synchronous brain metastasis in stage T1 lung adenocarcinoma.

Methods

A retrospective analysis was conducted on lung adenocarcinoma patients treated at Zhongnan Hospital of Wuhan University from August 2017 to October 2023. We screened for T1⁃stage cases with synchronous brain metastasis and

based on tumor maximum diameter

selected T1⁃stage cases without brain metastasis by propensity score matching (PSM) as controls. Clinical characteristics and CT imaging features were compared between the two groups

and risk factors for synchronous brain metastasis were identified using multivariable logistic regression.

Results

Cases of T1 stage lung adenocarcinoma with synchronous brain metastasis were selected

and propensity score matching (PSM) was used to match T1 stage cases without brain metastasis as the control

group based on the maximum tumor diameter. Univariate analysis showed that there were statistically significant differences in nodal‑spinal distance

vascular cluster sign

epidermal growth factor receptor (EGFR) mutation status

and serum carcinoembryonic antigen (CEA) between the two groups （

0.05）. Multivariable logistic regression analysis suggested that EGFR mutation status and CEA were independent risk factors for synchronous brain metastasis in stage T1 lung adenocarcinoma（

0.05）.

Conclusion

EGFR mutation and elevated serum CEA were independent risk factors for synchronous brain metastasis in stage T1 lung adenocarcinoma.

关键词

Keywords

references

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