Clinical efficacy analysis of sensitive antibiotics combined with Polyhexanide dressing in the treatment of infectious wounds

WANG Xin; LIU Changhuan; ZHOU Min; FANG Xue; ZHANG Wang; WANG Weixing; YANG Xiaqing

doi:10.14188/j.1671-8852.2024.0694

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Clinical efficacy analysis of sensitive antibiotics combined with Polyhexanide dressing in the treatment of infectious wounds

更新时间：2026-11-05

- Clinical efficacy analysis of sensitive antibiotics combined with Polyhexanide dressing in the treatment of infectious wounds
- Medical Journal of Wuhan University Vol. 46, Issue 9, Pages: 1179-1184(2025)
- 作者机构：
  
  1.武汉大学中南医院创伤与显微骨科湖北武汉 430071
  2.巴东县人民医院湖北恩施 444300
  3.武汉大学中南医院老年髋部骨折诊疗中心湖北武汉 430071
- 作者简介：
- 基金信息：
- DOI：10.14188/j.1671-8852.2024.0694
  CLC： R63
- Received：11 September 2024，
  
  Published：26 September 2025
- 稿件说明：
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王欣,柳昌焕,周敏等.敏感抗生素联合普朗特敷料治疗感染性创面的临床疗效分析[J].武汉大学学报（医学版）,2025,46(09):1179-1184.

WANG Xin,LIU Changhuan,ZHOU Min,et al.Clinical efficacy analysis of sensitive antibiotics combined with Polyhexanide dressing in the treatment of infectious wounds[J].Medical Journal of Wuhan University,2025,46(09):1179-1184.
王欣,柳昌焕,周敏等.敏感抗生素联合普朗特敷料治疗感染性创面的临床疗效分析[J].武汉大学学报（医学版）,2025,46(09):1179-1184. DOI： 10.14188/j.1671-8852.2024.0694.

WANG Xin,LIU Changhuan,ZHOU Min,et al.Clinical efficacy analysis of sensitive antibiotics combined with Polyhexanide dressing in the treatment of infectious wounds[J].Medical Journal of Wuhan University,2025,46(09):1179-1184. DOI： 10.14188/j.1671-8852.2024.0694.

摘要

目的

探讨敏感抗生素联合普朗特敷料治疗感染性创面的临床疗效。

方法

回顾性分析武汉大学中南医院创伤与显微骨科2016年1月至2020年1月期间收治的78例感染性创面患者资料。根据治疗方法的不同，将患者分为普朗特组和对照组。普朗特组39例，采用敏感抗生素联合普朗特液体伤口敷料或普朗特凝胶换药治疗；对照组39例，采用敏感抗生素联合常规换药治疗。评估两组患者创面细菌培养转阴时间、清创次数、Bates‑Jensen伤口评价工具(BWAT)和住院时间。

结果

术后随访6~12个月，平均随访（7.51±1.46）个月。普朗特组患者创面细菌培养转阴时间为（7.62±1.70） d，显著短于对照组患者（8.82±1.30） d(

0.05)；普朗特组患者的清创次数为2.00（2.00

3.00）次，显著低于对照组患者的清创次数4.00（3.00

4.00）次(

0.05)；普朗特组患者BWAT评分下降幅度（17.21±2.31）分，对照组患者BWAT评分下降幅度（12.15±1.71）分，普朗特组患者BWAT评分下降幅度显著大于对照组(

0.05)；普朗特组患者住院时间为（11.82±1.96） d，显著低于对照组患者的时间（17.15±2.35） d(

0.05)。

结论

敏感抗生素联合普朗特敷料治疗感染性创面效果良好，不仅有助于创面快速愈合，还可缩短创面细菌感染时间，减少清创次数，降低BWAT评分，减少住院天数，改善创面外观，具有较高的临床应用价值。

Abstract

Objective

To investigate the clinical efficacy of polyhexanide in the treatment of infectious wounds.

Methods

The data of 78 patients with infectious wounds admitted to Zhongnan Hospital of Wuhan University from January 2016 to January 2020 were retrospectively analyzed

and according to different treatment methods

the patients were divided into two groups. The polyhexanide group (39 cases) received sensitive antibiotics combined with polyhexanide liquid wound dressing or polyhexanide gel dressing change

and the control group (39 cases) received sensitive antibiotics combined with conventional dressing change. Time to negative bacterial culture conversion

debridement times

Bates‑Jensen Wound Assessment Tool (BWAT) and length of hospital stay were evaluated in both groups.

Results

The average follow‑up was (7.51±1.46) months for 6⁃12 months. The time for wound bacterial culture to turn negative in polyhexanide group was (7.62±1.70) d

which was significantly shorter than (8.82±1.30) d in control group (

0.05). The debridement frequency of polyhexanide group was 2.00 (2.00

3.00) times

significantly lower than the 4.00 (3.00

4.00) times in the control group (

0.05). The decrease of BWAT score in polyhexanide group was （17.21±2.31） points

and that in control group was （12.15±1.71） points

with a statistically significant difference (

0.05). The hospitalization time of polyhexanide group was (11.82±1.96) d

which was significantly lower than (17.15±2.35) d of control group (

0.05).

Conclusion

Polyhexanide is effective in the treatment of infected wounds

as it can not only help the wound heal quickly

but also shorten the time of bacterial infection and hospitalization stay

reduce the debridement times and BWAT scores

and optimize wound presentation.

关键词

Keywords

references

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