Role of SIRT‑mediated mitochondrial quality control in osteoarthritis disease progression

SHI Rui; REN Xunshan; ZHUANG Huangming; ZHOU Panghu

doi:10.14188/j.1671-8852.2024.0678

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Role of SIRT‑mediated mitochondrial quality control in osteoarthritis disease progression

更新时间：2026-11-05

- Role of SIRT‑mediated mitochondrial quality control in osteoarthritis disease progression
- Medical Journal of Wuhan University Vol. 46, Issue 11, Pages: 1494-1499(2025)
- 作者机构：
  
  武汉大学人民医院骨科湖北武汉 430060
- 作者简介：
- 基金信息：
- DOI：10.14188/j.1671-8852.2024.0678
  CLC： R6
- Received：05 September 2024，
  
  Published：25 November 2025
- 稿件说明：
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师瑞,任洵杉,庄煌铭等.SIRT介导的线粒体质量控制在骨关节炎中的研究进展[J].武汉大学学报（医学版）,2025,46(11):1494-1499.

SHI Rui,REN Xunshan,ZHUANG Huangming,et al.Role of SIRT‑mediated mitochondrial quality control in osteoarthritis disease progression[J].Medical Journal of Wuhan University,2025,46(11):1494-1499.
师瑞,任洵杉,庄煌铭等.SIRT介导的线粒体质量控制在骨关节炎中的研究进展[J].武汉大学学报（医学版）,2025,46(11):1494-1499. DOI： 10.14188/j.1671-8852.2024.0678.

SHI Rui,REN Xunshan,ZHUANG Huangming,et al.Role of SIRT‑mediated mitochondrial quality control in osteoarthritis disease progression[J].Medical Journal of Wuhan University,2025,46(11):1494-1499. DOI： 10.14188/j.1671-8852.2024.0678.

摘要

骨关节炎（OA）是骨科常见的慢性退行性关节疾病，对个人和社会均会产生重大影响。OA影响关节的所有部位，其特征是导致细胞死亡和细胞外基质降解。线粒体是能量代谢和氧化还原平衡的传感器，其正常功能在OA的发生和进展中都起着至关重要的作用。SIRT是一类具有酶活性的蛋白质，参与了许多与线粒体代谢有关的通路，同时通过参与多种生理途径影响OA的疾病进展。该文综述了OA中SIRT介导的线粒体质量控制机制，旨在为OA的治疗提供新的靶点和研究方向。

Abstract

Osteoarthritis (OA) is a common chronic degenerative joint disease that imposes a major burden on individuals and society. OA affects all joint tissues and is characterized by cell death and extracellular matrix degradation. Mitochondria⁃sensors of energy metabolism and redox homeostasis⁃are crucial for OA onset and progression. SIRT

a family of NAD⁺⁃dependent enzymes

regulates mitochondrial metabolism and modulate OA progression through multiple signaling pathways. This review summarizes SIRT⁃mediated mitochondrial quality⁃control mechanisms in OA to identify novel therapeutic targets and research directions.

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references

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