Expression and prognostic value of lncRNA TPRG1‑AS1 in peripheral blood of patients with acute coronary syndrome

LI Wei; HE Liqun; ZHANG Fan

doi:10.14188/j.1671-8852.2024.0663

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Expression and prognostic value of lncRNA TPRG1‑AS1 in peripheral blood of patients with acute coronary syndrome

更新时间：2026-11-05

- Expression and prognostic value of lncRNA TPRG1‑AS1 in peripheral blood of patients with acute coronary syndrome
- Medical Journal of Wuhan University Vol. 46, Issue 10, Pages: 1301-1306(2025)
- 作者机构：
  
  武汉市第一医院心内科湖北武汉 430022
- 作者简介：
- 基金信息：
- DOI：10.14188/j.1671-8852.2024.0663
  CLC： R541.4
- Received：01 September 2024，
  
  Published：25 October 2025
- 稿件说明：
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李威,贺立群,张帆.急性冠脉综合征患者外周血lncRNA TPRG1‑AS1的表达及预后价值[J].武汉大学学报（医学版）,2025,46(10):1301-1306.

LI Wei,HE Liqun,ZHANG Fan.Expression and prognostic value of lncRNA TPRG1‑AS1 in peripheral blood of patients with acute coronary syndrome[J].Medical Journal of Wuhan University,2025,46(10):1301-1306.
李威,贺立群,张帆.急性冠脉综合征患者外周血lncRNA TPRG1‑AS1的表达及预后价值[J].武汉大学学报（医学版）,2025,46(10):1301-1306. DOI： 10.14188/j.1671-8852.2024.0663.

LI Wei,HE Liqun,ZHANG Fan.Expression and prognostic value of lncRNA TPRG1‑AS1 in peripheral blood of patients with acute coronary syndrome[J].Medical Journal of Wuhan University,2025,46(10):1301-1306. DOI： 10.14188/j.1671-8852.2024.0663.

摘要

目的

探讨长链非编码RNA（lncRNA）TPRG1‑AS1在急性冠脉综合征（ACS）发病和发展过程中的表达和意义，旨在探索一种新型生物标志物，用于ACS的诊断和预后。

方法

共纳入109名ACS患者和66名接受冠状动脉造影术但排除ACS的患者，通过PCR分析研究对象血清中的TPRG1‑AS1，通过ROC分析评估TPRG1‑AS1在筛查ACS中的意义，采用Pearson相关性检验评价TPRG1‑AS1与ACS疾病严重程度的关系。采用Logistic回归分析评估TPRG1‑AS1预测主要心血管不良事件（MACE）发生的潜在关系。

结果

在ACS患者血清中TPRG1‑AS1的表达显著上调，是ACS的危险因素。TPRG1‑AS1与ACS患者的Gensini评分、胱抑素C(Cys⁃C)、心肌肌钙蛋白I(cTnI)和NT‑proBNP水平呈正相关。此外，血清TPRG1‑AS1的升高与患者住院期间MACE的高发生率有关，并被确定为ACS患者发生MACE的危险因素。

结论

血清中TPRG1‑AS1的升高可作为诊断ACS的生物标志物，对患者病情的严重程度有一定的预测价值。

Abstract

Objective

To explore the expression and significance of long non‑coding RNA (lncRNA) TPRG1‑AS1 in the pathogenesis and development of acute coronary syndrome (ACS)

in order to explore a novel biomarker for the diagnosis and prognosis of acute coronary syndrome.

Methods

A total of 109 patients with ACS and 66 patients receiving coronary angiography but excluding ACS were included in this study. The significance of TPRG1‑AS1 in screening ACS was evaluated by PCR analysis of serum TPRG1‑AS1 of the study subjects and ROC analysis. Pearson correlation test was used to evaluate the relationship between TPRG1⁃AS1 and disease severity of ACS. Logistic regression analysis was used to evaluate the potential relationship of TPRG1‑AS1 to predict the occurrence of major adverse cardiovascular events (MACE).

Results

The expression of TPRG1⁃AS1 in serum of patients with ACS was significantly up‑regulated

which is a risk factor for ACS. TPRG1‑AS1 is positively correlated with Gensini score

Cys⁃C

cTnI and NT‑proBNP levels of patients with ACS. In addition

elevated serum TPRG1‑AS1 is associated with a higher incidence of MACE during hospitalization and has been identified as a risk factor for MACE in patients with ACS.

Conclusion

The increase of serum TPRG1‑AS1 can be used as a biomarker for the diagnosis of ACS and has certain predictive value for the severity of the disease. Upregulated TPRG1‑AS1 in ACS served as a diagnostic biomarker and predicted the severe development of patients.

关键词

Keywords

references

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