Research progress of sepsis‑associated encephalopathy

LEI Zihan; WU Xiaojing

doi:10.14188/j.1671-8852.2024.0549

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Research progress of sepsis‑associated encephalopathy

更新时间：2026-11-05

- Research progress of sepsis‑associated encephalopathy
- Medical Journal of Wuhan University Vol. 46, Issue 10, Pages: 1358-1363(2025)
- 作者机构：
  
  武汉大学人民医院麻醉科湖北武汉 430060
- 作者简介：
- 基金信息：
- DOI：10.14188/j.1671-8852.2024.0549
  CLC： R459.7
- Received：19 July 2024，
  
  Published：25 October 2025
- 稿件说明：
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雷紫涵,吴晓静.脓毒症相关性脑病的研究进展[J].武汉大学学报（医学版）,2025,46(10):1358-1363.

LEI Zihan,WU Xiaojing.Research progress of sepsis‑associated encephalopathy[J].Medical Journal of Wuhan University,2025,46(10):1358-1363.
雷紫涵,吴晓静.脓毒症相关性脑病的研究进展[J].武汉大学学报（医学版）,2025,46(10):1358-1363. DOI： 10.14188/j.1671-8852.2024.0549.

LEI Zihan,WU Xiaojing.Research progress of sepsis‑associated encephalopathy[J].Medical Journal of Wuhan University,2025,46(10):1358-1363. DOI： 10.14188/j.1671-8852.2024.0549.

摘要

脓毒症相关性脑病（SAE）是脓毒症引起的弥漫性脑功能障碍，与延长患者住院时间和死亡率增加高度相关，可能导致永久性神经系统后遗症。SAE的病理生理机制较为复杂，可能包括神经炎症、血脑屏障功能障碍、脑微循环障碍、神经递质功能异常及氧化应激等。目前针对SAE的特异性诊断和治疗措施仍然缺乏，主要依赖基于临床表现的意识状态评估和早期预防、对症治疗。虽然近年来也出现了一些特异性治疗方法，但仍处于研究阶段，还远未能应用于临床。因此，进一步研究SAE的病理生理机制，探寻可靠的诊断和治疗措施十分重要。

Abstract

Sepsis‑associated encephalopathy (SAE) is a sepsis‑induced diffuse brain dysfunction that is highly associated with prolonged hospital stay and increased mortality in patients

and may result in permanent neurological sequelae. The pathophysiology of SAE is complex and may include neuroinflammation

blood‑brain barrier dysfunction

cerebral microcirculatory disorders

neurotransmitter dysfunction

and oxidative stress. The specific diagnosis and treatment measures for SAE are still lacking

and mainly rely on the assessment of conscious state

early prevention

and symptomatic treatment. Though many specific treatments have emerged recently

they are still in the research phase and will not be used in a clinic immediately. Therefore

it is important to further research the pathophysiology of SAE and to explore reliable diagnostic and treatment measures.

关键词

Keywords

references

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