Comparison of the efficacy of sulodexide injection and low molecular weight heparin in acute respiratory distress syndrome patients

PENG Wei; LIU Zhou; HOU Yanguang; LI Zhenwen; JIANG Guijun; SHI Zhaokun; ZHANG Zhaocai; SONG Zhenju; ZHAN Liying; LI Guang

doi:10.14188/j.1671-8852.2024.0528

您当前的位置：

首页 >

文章列表页 >

Comparison of the efficacy of sulodexide injection and low molecular weight heparin in acute respiratory distress syndrome patients

更新时间：2026-11-05

- Comparison of the efficacy of sulodexide injection and low molecular weight heparin in acute respiratory distress syndrome patients
- Medical Journal of Wuhan University Vol. 46, Issue 2, Pages: 181-186(2025)
- 作者机构：
  
  1.武汉大学人民医院重症医学科湖北武汉 430060
  2.浙江大学医学院附属第二医院重症医学科/浙江省急危重症临床医学研究中心浙江杭州 310009
  3.复旦大学附属中山医院急诊科/复旦大学应急救援与急危重症研究所上海 200032
- 作者简介：
- 基金信息：
- DOI：10.14188/j.1671-8852.2024.0528
  CLC： R459.7
- Received：11 July 2024，
  
  Published：25 February 2025
- 稿件说明：
移动端阅览
彭卫,柳舟,侯彦广等.舒洛地特注射液与低分子肝素在急性呼吸窘迫综合征患者中的应用效果比较[J].武汉大学学报（医学版）,2025,46(02):181-186.

PENG Wei,LIU Zhou,HOU Yanguang,et al.Comparison of the efficacy of sulodexide injection and low molecular weight heparin in acute respiratory distress syndrome patients[J].Medical Journal of Wuhan University,2025,46(02):181-186.
彭卫,柳舟,侯彦广等.舒洛地特注射液与低分子肝素在急性呼吸窘迫综合征患者中的应用效果比较[J].武汉大学学报（医学版）,2025,46(02):181-186. DOI： 10.14188/j.1671-8852.2024.0528.

PENG Wei,LIU Zhou,HOU Yanguang,et al.Comparison of the efficacy of sulodexide injection and low molecular weight heparin in acute respiratory distress syndrome patients[J].Medical Journal of Wuhan University,2025,46(02):181-186. DOI： 10.14188/j.1671-8852.2024.0528.

摘要

目的

比较舒洛地特（SDX）注射液和低分子肝素（LMWH）应用在急性呼吸窘迫综合征（ARDS）患者中的安全性及疗效。

方法

纳入2020年4月—2024年4月于武汉大学人民医院重症医学科住院的ARDS患者共40例，根据实际用药分为舒洛地特（SDX）组（20例）和低分子肝素（LMWH）组（20例）。采用独立样本

检验、Mann⁃Whitney

检验及卡方检验等统计学方法比较两组患者在一般资料、总住院时间、ICU住院时间、机械通气时间、血常规、凝血功能、肝功能指标及血气结果上的差异。

结果

两组患者一般情况、总住院时间及ICU住院时间的比较差异无统计学意义（

0.05）。与LMWH组相比，SDX组患者的机械通气时间减少（

0.05）。两组患者在用药后活化部分凝血活酶时间（APTT）均有延长，LMWH组患者治疗后纤维蛋白原（FIB）降低，SDX组患者治疗后白蛋白升高，两组患者给药后均出现红细胞计数（RBC）降低、血红蛋白（Hb）减少以及动脉血氧饱和度（SaO

）降低（

0.05）。两组患者给药前后丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、血小板计数（PLT）、D⁃二聚体对比差异均无统计学意义（

0.05）。

结论

相较于使用低分子肝素，ARDS患者使用舒洛地特注射液能够降低机械通气时间，且不会引起肝功能损伤、血小板降低等不良反应。

Abstract

Objective

To compare the safety and efficacy of sulodexide (SDX) versus low molecular weight heparin (LMWH) in patients with acute respiratory distress syndrome (ARDS) through a retrospective study.

Methods

A retrospective cohort study included 40 ARDS patients hospitalized in the Department of Critical Care Medicine at Renmin Hospital of Wuhan University from April 2020 to April 2024. According to the actual medication

patients were divided into two groups: the SDX group (20 cases) and the LMWH group (20 cases). General conditions

total length of hospital stay

length of ICU stay

mechanical ventilation time

as well as blood routine

coagulation function

liver function

and blood gas results were compared between the SDX group and the LMWH group.

Results

There was no statistically significant difference in the general conditions

total hospitalization time

and ICU stay between the two groups (

0.05). Compared with those in the LMWH group

the mechanical ventilation time of patients in the SDX group was reduced (

0.05). Activated partial thromboplastin time (APTT) was prolonged in both groups after drug administration

fibrinogen (FIB) was decreased in patients in the LMWH group

and albumin was increased in patients in the SDX group after treatment. A decrease in red blood cell count (RBC)

a reduction in hemoglobin (Hb)

and a decrease in blood oxygen

saturation (SaO

) were observed in both groups after drug administration (

0.05). No statistically significant changes were found in alanine aminotransferase (ALT)

aspartate aminotransferase (AST)

platelet count (PLT)

and D⁃dimer after drug administration in both groups (

0.05).

Conclusion

Compared with the low molecular weight heparin

sulodexide injection in patients with ARDS reduces the duration of mechanical ventilation and does not cause adverse effects such as hepatic impairment and platelet reduction.

关键词

Keywords

references

Matthay M A , Arabi Y , Arroliga A C , et al . A new global definition of acute respiratory distress syndrome [J ] . Am J Respir Crit Care Med , 2024 , 209 ( 1 ): 37 ⁃ 47 .

Bellani G , Laffey J G , Pham T , et al . Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries [J ] . JAMA , 2016 , 315 ( 8 ): 788 ⁃ 800 .

Livingstone S A , Wildi K S , Dalton H J , et al . Coagulation dysfunction in acute respiratory distress syndrome and its potential impact in inflammatory subphenotypes [J ] . Front Med , 2021 , 8 : 723217 .

Gando S , Wada T . Pathomechanisms underlying hypoxemia in two COVID⁃19⁃associated acute respiratory distress syndrome phenotypes: Insights from thrombosis and hemostasis [J ] . Shock , 2022 , 57 ( 1 ): 1 ⁃ 6 .

Li J , Pan G . Association of coagulation function with the risk of in⁃hospital mortality in patients with severe acute respiratory distress syndrome [J ] . Am J Med Sci , 2024 , 368 ( 2 ): 143 ⁃ 152 .

中国研究型医院学会危重医学专委会, 宁波诺丁汉大学GRADE中心, 孙同文 . 中国成人急性呼吸窘迫综合征(ARDS)诊断与非机械通气治疗指南(2023) [J ] . 中国研究型医院 , 2023 , 10 ( 5 ): 9 ⁃ 24 .

Special Committee of Critical Care Medicine of Chinese Research Hospital Association , GRADE Centre University of Nottingham Ningbo China , Sun TW . Guidelines for diagnosis of adult acute respiratory distress syndrome(ARDS) in China and non⁃mechanical ventilation treatment(2023) [J ] . J Chin Res Hosp , 2023 , 10 ( 5 ): 9 ⁃ 24 .

吴朝阳 , 李湛军 , 董武军 . 多糖类抗血栓药物舒洛地特与低分子肝素的多方位比较分析 [J ] . 中国药事 , 2023 , 37 ( 7 ): 817 ⁃ 824 .

Wu C Y , Li Z J , Dong W J . Multi⁃dimensional comparison between sulodexide and low molecular weight heparin of polysaccharide antithrombotic drugs [J ] . Chin Pharm Aff , 2023 , 37 ( 7 ): 817 ⁃ 824 .

Carroll B J , Piazza G , Goldhaber S Z . Sulodexide in venous disease [J ] . J Thromb Haemost , 2019 , 17 ( 1 ): 31 ⁃ 38 .

Bos L D J , Ware L B . Acute respiratory distress syndrome: Causes, pathophysiology, and phenotypes [J ] . Lancet , 2022 , 400 ( 10358 ): 1145 ⁃ 1156 .

Meyer N J , Gattinoni L , Calfee C S . Acute respiratory distress syndrome [J ] . The Lancet , 2021 ( 10300 ): 398 : 622 ⁃ 637 .

Whyte C S , Morrow G B , Mitchell J L , et al . Fibrinolytic abnormalities in acute respiratory distress syndrome (ARDS) and versatility of thrombolytic drugs to treat COVID⁃19 [J ] . J Thromb Haemost , 2020 , 18 ( 7 ): 1548 ⁃ 1555 .

Morrow G B , Mutch N J . Past, present, and future perspectives of plasminogen activator inhibitor 1 (PAI⁃1) [J ] . Semin Thromb Hemost , 2023 , 49 ( 3 ): 305 ⁃ 313 .

郑兴昊 , 沈锋 , 李想 , 等 . 持续低剂量肝素和低分子肝素抗凝治疗对急性呼吸窘迫综合征患者预后的荟萃分析 [J ] . 中华危重病急救医学 , 2020 , 32 ( 12 ): 1479 ⁃ 1486 .

Zheng X H , Shen F , Li X , et al . Meta⁃analysis of the impact of continuous anticoagulation therapy with low⁃dose heparin or low molecular weight heparin on the prognosis of patients with acute respiratory distress syndrome [J ] . Chin Crit Care Med , 2020 , 32 ( 12 ): 1479 ⁃ 1486 .

Suzuki A , Tomita H , Okada H . Form follows function: The endothelial glycocalyx [J ] . Transl Res , 2022 , 247 : 158 ⁃ 167 .

Uchimido R , Schmidt E P , Shapiro N I . The glycocalyx: A novel diagnostic and therapeutic target in sepsis [J ] . Crit Care , 2019 , 23 ( 1 ): 16 .

Dauth A , Bręborowicz A , Ruan Y , et al . Sulodexide prevents hyperglycemia⁃induced endothelial dysfunction and oxidative stress in porcine retinal arterioles [J ] . Antioxidants , 2023 , 12 ( 2 ): 388 .

Taenaka H , Matthay M A . Mechanisms of impaired alveolar fluid clearance [J ] . Anat Rec , 2023 : 10.1002/ar.25166 .

蒋湘粤 , 冯芮华 , 刘江萍 , 等 . 低分子肝素对急性呼吸窘迫综合征患者临床疗效影响的Meta分析 [J ] . 中华危重病急救医学 , 2020 , 32 ( 12 ): 1472 ⁃ 1478 .

Jiang X Y , Feng R H , Liu J P , et al . Meta⁃analysis of the curative effect of low molecular weight heparin on acute respiratory distress syndrome [J ] . Chin Crit Care Med , 2020 , 32 ( 12 ): 1472 ⁃ 1478 .

陈霞 , 谭兵 . 低分子肝素致不良反应69例文献分析 [J ] . 中国药房 , 2013 , 24 ( 20 ): 1898 ⁃ 1900 .

Chen X , Tan B . Literature analysis of 69 ADR cases induced by low molecular weight heparin [J ] . China Pharm , 2013 , 24 ( 20 ): 1898 ⁃ 1900 .

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Safety and effectiveness of high⁃frequency oscillatory ventilation for the treatment of acute respiratory distress syndrome: A meta⁃analysis

Research progress on ADAMTS4 in acute lung injury/acute respiratory distress syndrome

Comparative clinical efficacy of different acid formulations in the treatment of scalp seborrheic dermatitis

Biomechanical injury induces mitochondrial autophagy in L929 cells by downregulating the TGF‐β/Smad3 signaling pathway

Research advance on the relationship between intestinal fungi and digestive system tumor

Related Author

ZHANG Zhaocai

LIU Zhou

ZHANG Liang

LI Guang

HOU Yanguang

CHEN Qianqian

PENG Wei

YANG Qiaoyu

Related Institution

Dept. of Critical Care Medicine， The Second Affiliated Hospital Zhejiang University School of Medicine & Zhejiang Province Clinical Research Center for Emergency and Critical Care Medicine

Department of Critical Care Medicine, Renmin Hospital of Wuhan University

Department of Radiology, Renmin Hospital of Wuhan University

Department of Respiratory and Critical Care Medicine, Yichang Central People's Hospital

Dept. of Critical Care Medicine, Renmin Hospital of Wuhan University

AI问答

⁰