Clinical trials related to acute respiratory distress syndrome: Current status and challenges

LUO Weiwei; HUANG Tiancha; ZHANG Zhaocai

doi:10.14188/j.1671-8852.2024.0493

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Clinical trials related to acute respiratory distress syndrome: Current status and challenges

更新时间：2026-11-05

- Clinical trials related to acute respiratory distress syndrome: Current status and challenges
- Medical Journal of Wuhan University Vol. 46, Issue 2, Pages: 232-238(2025)
- 作者机构：
  
  浙江大学医学院附属第二医院重症医学科/浙江省急危重症临床医学研究中心浙江杭州 310009
- 作者简介：
- 基金信息：
- DOI：10.14188/j.1671-8852.2024.0493
  CLC： R563.8
- Received：03 July 2024，
  
  Published：25 February 2025
- 稿件说明：
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罗薇薇,黄添姹,张召才.急性呼吸窘迫综合征相关临床研究：现状与挑战[J].武汉大学学报（医学版）,2025,46(02):232-238.

LUO Weiwei,HUANG Tiancha,ZHANG Zhaocai.Clinical trials related to acute respiratory distress syndrome: Current status and challenges[J].Medical Journal of Wuhan University,2025,46(02):232-238.
罗薇薇,黄添姹,张召才.急性呼吸窘迫综合征相关临床研究：现状与挑战[J].武汉大学学报（医学版）,2025,46(02):232-238. DOI： 10.14188/j.1671-8852.2024.0493.

LUO Weiwei,HUANG Tiancha,ZHANG Zhaocai.Clinical trials related to acute respiratory distress syndrome: Current status and challenges[J].Medical Journal of Wuhan University,2025,46(02):232-238. DOI： 10.14188/j.1671-8852.2024.0493.

摘要

急性呼吸窘迫综合征（ARDS）是由各种肺内或肺外因素导致的临床综合征，发病率和死亡率高。关于ARDS的治疗探索从未停滞，但相关临床研究陷入困境，保护性机械通气策略仍是当前唯一被证实有效的标准疗法，其原因可能与ARDS的高度异质性有关。本文聚焦于ARDS相关的临床研究，通过分析临床治疗的现状和挑战，提出增进ARDS临床研究客观性和精准性的建议。

Abstract

Acute respiratory distress syndrome (ARDS) is a clinical syndrome caused by various pulmonary or extrapulmonary factors

with high morbidity and mortality. The exploration of treatments for ARDS has never stopped

but related clinical research has encountered difficulties. Protective mechanical ventilation strategy remains the only proven effective standard therapy

which may be related to the high heterogeneity of ARDS. This article focuses on clinical trials related to ARDS

analyzes the current situation and challenges of clinical treatment

and proposes suggestions to improve the objectivity and accuracy of ARDS clinical trials.

关键词

Keywords

references

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