Analysis of quality of life and influencing factors of patients with different phenotypes of polycystic ovary syndrome

CHENG Qiujin; YANG Hongyan; WANG Weibing

doi:10.14188/j.1671-8852.2024.0478

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Analysis of quality of life and influencing factors of patients with different phenotypes of polycystic ovary syndrome

更新时间：2026-11-05

- Analysis of quality of life and influencing factors of patients with different phenotypes of polycystic ovary syndrome
- Medical Journal of Wuhan University Vol. 46, Issue 6, Pages: 781-786(2025)
- 作者机构：
  
  潜江市中心医院妇科湖北潜江 433199
- 作者简介：
- 基金信息：
- DOI：10.14188/j.1671-8852.2024.0478
  CLC： R587.1
- Received：27 June 2024，
  
  Published：25 June 2025
- 稿件说明：
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程秋瑾,杨红艳,王卫兵.不同表型的多囊卵巢综合征患者的生活质量及影响因素分析[J].武汉大学学报（医学版）,2025,46(06):781-786.

CHENG Qiujin,YANG Hongyan,WANG Weibing.Analysis of quality of life and influencing factors of patients with different phenotypes of polycystic ovary syndrome[J].Medical Journal of Wuhan University,2025,46(06):781-786.
程秋瑾,杨红艳,王卫兵.不同表型的多囊卵巢综合征患者的生活质量及影响因素分析[J].武汉大学学报（医学版）,2025,46(06):781-786. DOI： 10.14188/j.1671-8852.2024.0478.

CHENG Qiujin,YANG Hongyan,WANG Weibing.Analysis of quality of life and influencing factors of patients with different phenotypes of polycystic ovary syndrome[J].Medical Journal of Wuhan University,2025,46(06):781-786. DOI： 10.14188/j.1671-8852.2024.0478.

摘要

目的

评估不同多囊卵巢综合征（PCOS）患者的生活质量（QoL）并分析其影响因素。

方法

采用横断面设计，将2018年1月1日—2019年12月31日88例首次诊断为PCOS并在潜江市中心医院妇产科建立记录的汉族女性纳入研究。参照鹿特丹标准进行PCOS分型，将所有患者分为26例表型A、12例表型B、22例表型C、28例表型D。使用多囊卵巢综合征健康相关生活质量问卷修正版（MPCOSQ）调查研究对象的QoL。

结果

人体测量指标中，不同PCOS表型研究人群的体质量存在显著差异（

0.05）。相对于表型C和表型D患者，具有表型A和B的女性表现出显著更高的胰岛素水平、胰岛素抵抗指数（HOMA⁃IR）和总睾酮（

0.05），而表型A和B之间没有观察到统计学差异。此外，4种PCOS表型的当前月经状态存在显著差异（

=0.036），表型A、B和D月经正常人数显著低于表型C（

0.05）。PCOS不同表型的MPCOSQ总分存在显著差异（

0.05）；在多毛症亚组中，表型A和B得分显著低于表型C和D（

0.05）。在痤疮亚组中，表型A、B和C得分显著低于表型D（

0.05）。在月经症状亚组中，表型A、B和D得分显著低于表型C（

0.05）。表型A和B中较低的QoL与体质量（

=-0.388、-0.627，

0.001），多毛症（

=-0.310、-0.271，

0.01）和月经异常（

=-0.284、-0.305，

0.01）显著关联。表型C、D中较低的QoL与体质量（

=-0.437、-0.295，

0.01）和月经异常（

=-0.337、-0.387，

0.001）显著关联。

结论

表型A、B的QoL评分显著低于表型C、D。科学减肥，针对表型A和B结合抗雄激素给药并针对表型C和D提高生育能力可改善PCOS患者的生活质量。

Abstract

Objective

To evaluate the quality of life (QoL) characteristics in women with distinct polycystic ovary syndrome (PCOS) phenotypes and explore factors related to reduced QoL.

Methods

A cross⁃sectional design was conducted. A total of 88 Han females were first diagnosed with PCOS and established a record at the Department of Obstetrics and Gynecology of Qianjiang Central Hospital from January 1

2018

to December 31

2019. The patients were assigned into three grouops according to the Rotterdam criteria as: 26 cases of phenotype A

12 cases of phenotype B

22 cases of phenotype C

and 28 cases of phenotype D. The QoL of the subjects was investigated using the modified polycystic ovary syndrome health⁃related quality of life questionnaire (MPCOSQ).

Results

Among anthropometric parameters

there were significant differences in body weight among different PCOS phenotype study populations (

0.05). Relative to the phenotype C and D patients

women with phenotypes A and B exhibited significantly higher insulin levels

HOMA⁃IR

and total testosterone (

0.05). At the same time

no difference was observed between phenotypes A and B. In addition

there was a significant difference in current menstruation status among the four PCOS phenotypes (

=0.036)

and the normal number of phenotypes A

and D was significantly lower than that of phenotype C (

0.05). The MPCOSQ total scores of different phenotypes of PCOS were significantly different (

0.05); in the hirsutism subgroup

phenotypes A and B scored patients were significantly lower than those of phenotypes C and D (

0.05). In the acne subgroup

phenotypes A

and C patients scored significantly lower than phenotype D patients (

0.05). In the menstrual symptom subgroup

phenotypes A

and D patients scored significantly lower than phenotype C patients (

0.05). Poor QoL in phenotypes A and B patients was associated with body weight (

=-0.388

-0.627

0.001)

hirsutism (

=-0.310

-0.271

0.01) and menstrual abnormalities (

=-0.284

-0.305

0.01). Poor QoL in phenotypes C and D patients was significantly associated with body weight (

=-0.437

-0.295

0.01) and menstrual abnorma

lities (

=-0.337

-0.387

0.001).

Conclusion

The QoL scores of phenotypes A and B patients were significantly lower than those of phenotypes C and D. Interventions to improve QoL in PCOS patients are scientific weight loss and combined antiandrogen administration for phenotypes A and B

and enhancing fertility for phenotypes C and D.

关键词

Keywords

references

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