Research advances on the mechanism of ferroptosis in synovial fibroblasts in rheumatoid arthritis

LIU Guanghua; SHI Dongliang; WANG Zihua; FU Wen; CUI Jiakang

doi:10.14188/j.1671-8852.2024.0453

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Research advances on the mechanism of ferroptosis in synovial fibroblasts in rheumatoid arthritis

更新时间：2026-11-05

- Research advances on the mechanism of ferroptosis in synovial fibroblasts in rheumatoid arthritis
- Medical Journal of Wuhan University Vol. 46, Issue 9, Pages: 1211-1217(2025)
- 作者机构：
  
  1.河南中医药大学骨伤学院河南郑州 450046
  2.河南中医药大学第二附属医院/河南省中医院骨伤病诊疗中心河南郑州 450002
  3.河南中医药大学第一附属医院风湿免疫科河南郑州 450014
- 作者简介：
- 基金信息：
- DOI：10.14188/j.1671-8852.2024.0453
  CLC： R392.3
- Received：15 June 2024，
  
  Published：26 September 2025
- 稿件说明：
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刘光华,史栋梁,王子华等.类风湿关节炎中滑膜成纤维细胞铁死亡的分子机制研究进展[J].武汉大学学报（医学版）,2025,46(09):1211-1217.

LIU Guanghua,SHI Dongliang,WANG Zihua,et al.Research advances on the mechanism of ferroptosis in synovial fibroblasts in rheumatoid arthritis[J].Medical Journal of Wuhan University,2025,46(09):1211-1217.
刘光华,史栋梁,王子华等.类风湿关节炎中滑膜成纤维细胞铁死亡的分子机制研究进展[J].武汉大学学报（医学版）,2025,46(09):1211-1217. DOI： 10.14188/j.1671-8852.2024.0453.

LIU Guanghua,SHI Dongliang,WANG Zihua,et al.Research advances on the mechanism of ferroptosis in synovial fibroblasts in rheumatoid arthritis[J].Medical Journal of Wuhan University,2025,46(09):1211-1217. DOI： 10.14188/j.1671-8852.2024.0453.

摘要

铁死亡是一种以铁离子依赖和脂质过氧化物积累为主要特征的新型调节性细胞死亡。在类风湿关节炎（RA）疾病进程中，滑膜成纤维细胞在具有铁死亡典型特征的铁过载和氧化应激的滑膜微环境中却能大量活化增殖，侵袭骨和软骨并造成关节畸形和功能丧失，从而加剧类风湿关节炎的病程。近年来相关研究表明类风湿关节炎的滑膜微环境中存在保护滑膜成纤维细胞免于铁死亡的独特机制，本文将综述类风湿关节炎中滑膜成纤维细胞铁死亡相关的分子作用机制，以期为类风湿关节炎的治疗提供新策略。

Abstract

Ferroptosis

a novel form of regulated cell death

is characterized by its dependence on iron ions and the accumulation of lipid peroxides. In rheumatoid arthritis (RA)

synovial fibroblasts inhabit an environment marked by iron overload and oxidative stress⁃two primary hallmarks of ferroptosis. Paradoxically

these fibroblasts demonstrate increased activation and proliferation

facilitating their invasion into bone and cartilage

which culminates in joint deformities

functional impairment

and exacerbation of RA symptoms. Recent studies have identified a unique mechanism within the synovial microenvironment of RA that protects synovial fibroblasts from undergoing ferroptosis. This review critically evaluates the mechanisms associated with ferroptosis in synovial fibroblasts within the context of rheumatoid arthritis

aiming to advance novel therapeutic approaches for RA management.

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Keywords

references

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