Research progress on deubiquitinase OTUD1 in cancer

SUN Liying; KE Shaobo; LIU Yi; HUANG Zhiqun; CHEN Yongshun

doi:10.14188/j.1671-8852.2024.0205

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Research progress on deubiquitinase OTUD1 in cancer

更新时间：2026-11-05

- Research progress on deubiquitinase OTUD1 in cancer
- Medical Journal of Wuhan University Vol. 46, Issue 9, Pages: 1161-1167(2025)
- 作者机构：
  
  1.武汉大学人民医院肿瘤中心湖北武汉 430060
  2.南华大学衡阳医学院基础医学院细胞生物学与遗传学系湖南衡阳 421001
  3.武汉大学人民医院耳鼻咽喉⁃头颈外科中心湖北武汉 430060
- 作者简介：
- 基金信息：
- DOI：10.14188/j.1671-8852.2024.0205
  CLC： R730.2
- Received：25 March 2024，
  
  Published：26 September 2025
- 稿件说明：
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孙利英,柯少波,刘奕等.去泛素化酶OTUD1在肿瘤中的研究进展[J].武汉大学学报（医学版）,2025,46(09):1161-1167.

SUN Liying,KE Shaobo,LIU Yi,et al.Research progress on deubiquitinase OTUD1 in cancer[J].Medical Journal of Wuhan University,2025,46(09):1161-1167.
孙利英,柯少波,刘奕等.去泛素化酶OTUD1在肿瘤中的研究进展[J].武汉大学学报（医学版）,2025,46(09):1161-1167. DOI： 10.14188/j.1671-8852.2024.0205.

SUN Liying,KE Shaobo,LIU Yi,et al.Research progress on deubiquitinase OTUD1 in cancer[J].Medical Journal of Wuhan University,2025,46(09):1161-1167. DOI： 10.14188/j.1671-8852.2024.0205.

摘要

泛素⁃蛋白酶体系统是体内主要的蛋白质降解途径。OTU去泛素酶1（OTUD1）是一种功能性的半胱氨酸蛋白酶，属于卵巢肿瘤蛋白酶家族。OTUD1在多种信号通路中通过去泛素化关键蛋白，对机体的病理和生理过程产生广泛影响。本文综述了OTUD1在恶性肿瘤中的作用及其参与的分子机制，探讨了将OTUD1作为新的治疗靶标的潜力，旨在为癌症治疗策略的开发提供理论基础和新的视角。

Abstract

The ubiquitin⁃proteasome system is the primary pathway for protein degradation within the body. OTU deubiquitinase 1 (OTUD1) is a functional cysteine protease and a member of the ovarian tumor protease family. OTUD1 plays a broad role in both pathological and physiological processes by deubiquitinating key proteins in various signaling pathways. This article reviews the role of OTUD1 in malignant tumors and its involvement in molecular mechanisms within related pathways

exploring the potential of OTUD1 as a new therapeutic target. This review aims to provide a theoretical basis and a new perspective for the development of cancer treatment strategies.

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references

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