Analysis of human papillomavirus infection of female for health check⁃up in Shiyan, Hubei

YAN Hui; RAN Fengying; LEI Yue; HUANG Huimin

doi:10.14188/j.1671-8852.2024.0188

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Analysis of human papillomavirus infection of female for health check⁃up in Shiyan, Hubei

更新时间：2026-11-05

- Analysis of human papillomavirus infection of female for health check⁃up in Shiyan, Hubei
- Medical Journal of Wuhan University Vol. 46, Issue 6, Pages: 776-780(2025)
- 作者机构：
  
  1.湖北医药学院附属国药东风总医院，妇产科，湖北十堰 442008
  2.湖北医药学院附属国药东风总医院，实验中心，湖北十堰 442008
  3.西安交通大学医学部药学院陕西西安 710003
- 作者简介：
- 基金信息：
- DOI：10.14188/j.1671-8852.2024.0188
  CLC： R172.1
- Received：19 March 2024，
  
  Published：25 June 2025
- 稿件说明：
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严慧,冉凤英,雷悦等.湖北十堰地区健康体检女性人乳头瘤病毒感染情况分析[J].武汉大学学报（医学版）,2025,46(06):776-780.

YAN Hui,RAN Fengying,LEI Yue,et al.Analysis of human papillomavirus infection of female for health check⁃up in Shiyan, Hubei[J].Medical Journal of Wuhan University,2025,46(06):776-780.
严慧,冉凤英,雷悦等.湖北十堰地区健康体检女性人乳头瘤病毒感染情况分析[J].武汉大学学报（医学版）,2025,46(06):776-780. DOI： 10.14188/j.1671-8852.2024.0188.

YAN Hui,RAN Fengying,LEI Yue,et al.Analysis of human papillomavirus infection of female for health check⁃up in Shiyan, Hubei[J].Medical Journal of Wuhan University,2025,46(06):776-780. DOI： 10.14188/j.1671-8852.2024.0188.

摘要

目的

分析近5年来湖北十堰地区健康体检女性人群中人乳头瘤病毒（HPV）感染率、感染亚型及在不同年龄段的分布情况。

方法

选取2017年10月—2022年10月在湖北医药学院附属国药东风总医院进行21种HPV亚型检测的女性体检者，收集其年龄等基本信息，分析其HPV检测结果、感染亚型、年龄分布。

结果

11 700例女性健康体检标本中，共检出HPV阳性患者1 003例，总阳性率

为8.57%(1 003/11 700)。感染率前3位的HPV高危亚型是：52型、58型、53型，阳性率分别为1.49%（174/11 700）、1.17%（137/11 700）、0.96%（112/11 700）；感染率前3位的低危亚型是：81型、44型、42型，阳性率分别为1.09%（127/11 700）、0.23%（27/11 700）、0.15%（18/11 700）。在

25岁、26~35岁、36~45岁、46~55岁、

55岁五个年龄组中，HPV感染率分别为10.87%（15/138）、7.25%（139/1 916）、8.43%（447/5 302）、9.08%（368/4 055）、11.76%（34/289）。不同年龄组中HPV总感染率存在统计学差异（

0.05），其中

55岁年龄组感染率最高，26~35岁年龄组感染率最低。HPV单一感染率为7.63%（893/11 700），二重感染率为0.83%（97/11 700），三重感染率为0.09%（10/11 700），四重及以上感染率为0.03%（3/11 700）。

结论

近5年来湖北十堰地区健康体检女性人群中HPV总感染率为8.57%，以单一感染最为常见，感染率随年龄增长先降低后增加，最常见的高危感染亚型为52型、58型和53型，感染高峰出现在>55岁和<25岁两个年龄段。

Abstract

Objective

To investigate the human papillomavirus (HPV) infection status and distribution in females undergoing health check⁃ups in Shiyan of Hubei Province over the past 5 years.

Methods

The females who underwent the HPV 21 genotype test in health check⁃ups from October 2017 to October 2022 at Sinopharm Dongfeng General Hospital

Hubei University of Medicine

were selected. Essential information

such as age

was collected via the electronic medical record system. The results of the HPV test and the distribution of HPV subtypes were analyzed.

Results

A total of 1 003 cases were HPV positive among the 11 700 female samples undergoing health check⁃ups

with a positive rate of 8.57% (1 003/11 700). The 3 most common types of high⁃risk HPV subtypes were HPV 52 (1.49%

174/11 700)

58 (1.17%

137/11 700)

and 53 (0.96%

112/11 700)

and those of low risk were HPV 81 (1.09%

127/11 700)

44 (0.23%

27/11 700)

and 42 (0.15%

18/11 700). The HPV⁃positive rates in groups aged

26~35

36~45

46~55

and

55 years old were 10.87% (15/138)

7.25% (139/1 916)

8.43% (447/5 302)

9.08% (368/4 055) and 11.76% (34/289)

respectively. HPV⁃positive rates showed statistically significant differences between ages (

0.05). The HPV⁃positive rate was highest in the group aged

55 years old and lowest in the group aged 26~35 years old. The single HPV positive rate was 7.63% (893/11 700); the double positive rate was 0.83% (97/11 700); the triple positive rate was 0.09% (10/11 700); and the quadruple or more positive rate was 0.03% (3/11 700).

Conclusion

The HPV⁃positive rate in females undergoing health check⁃ups was 8.57% in Hubei Shiyan for the past 5 years. The single HPV infection was the most common. The mainly high⁃risk HPV subtypes were HPV 52

and 53. The HPV infection peaks occurred in groups aged >55 years old and <25 years old.

关键词

Keywords

references

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