Application of intravenous thrombolysis and mechanical thrombectomy in the treatment of acute ischemic stroke

XIAO Shufeng; CHEN Yanli; GUO Jun; YU Fen; YANG Tangzhu

doi:10.14188/j.1671-8852.2024.0183

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Application of intravenous thrombolysis and mechanical thrombectomy in the treatment of acute ischemic stroke

更新时间：2026-11-05

- Application of intravenous thrombolysis and mechanical thrombectomy in the treatment of acute ischemic stroke
- Medical Journal of Wuhan University Vol. 46, Issue 9, Pages: 1190-1194(2025)
- 作者机构：
  
  1.湖北省天门市第一人民医院神经内科湖北天门 431700
  2.武汉市第三医院神经内科湖北武汉 430060
  3.华润武钢总医院神经内科湖北武汉 430080
- 作者简介：
- 基金信息：
- DOI：10.14188/j.1671-8852.2024.0183
  CLC： R743
- Received：17 March 2024，
  
  Published：26 September 2025
- 稿件说明：
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肖淑烽,陈艳丽,郭俊等.静脉溶栓机械取栓在治疗急性缺血性脑卒中患者中的应用[J].武汉大学学报（医学版）,2025,46(09):1190-1194.

XIAO Shufeng,CHEN Yanli,GUO Jun,et al.Application of intravenous thrombolysis and mechanical thrombectomy in the treatment of acute ischemic stroke[J].Medical Journal of Wuhan University,2025,46(09):1190-1194.
肖淑烽,陈艳丽,郭俊等.静脉溶栓机械取栓在治疗急性缺血性脑卒中患者中的应用[J].武汉大学学报（医学版）,2025,46(09):1190-1194. DOI： 10.14188/j.1671-8852.2024.0183.

XIAO Shufeng,CHEN Yanli,GUO Jun,et al.Application of intravenous thrombolysis and mechanical thrombectomy in the treatment of acute ischemic stroke[J].Medical Journal of Wuhan University,2025,46(09):1190-1194. DOI： 10.14188/j.1671-8852.2024.0183.

摘要

目的

探讨急性缺血性脑卒中（ACI）采用静脉溶栓、机械取栓治疗的临床效果。

方法

选取2022年2月—2023年2月湖北省天门市第一人民医院收治的90例ACI患者，按照治疗方法不同进行分组，对照组采取静脉溶栓治疗（

=48），研究组在此基础上联合机械取栓治疗（

=42），对比两组患者的治疗疗效、不良反应，并随访90 d，观察治疗前后的美国国立卫生研究院卒中量表（NIHSS）评分以及患者的预后情况。

结果

与对照组比较，研究组治疗疗效更高

（

0.05），研究组不良反应率较低（

0.05）。治疗前，两组NIHSS评分比较差异无统计学意义（

0.05），治疗后均有所降低（

0.05），与对照组相比，研究组治疗1 d、3 d、30 d以及90 d的NIHSS评分更低（

0.05）。以90 d为期限观察两组患者的预后，两组患者病死率比较差异无统计学意义（

0.05）；与对照组比较，研究组TICI≥2b级率更高、血管急性再闭塞率更低（

0.05）。

结论

静脉溶栓联合机械取栓用于ACI患者的治疗，疗效有效且安全，能够减轻患者的神经功能缺损程度，提高闭塞血管再通率。

Abstract

Objective

To investigate the clinical efficacy of intravenous thrombolysis and mechanical thrombectomy in the treatment of acute ischemic stroke (ACI).

Methods

Ninety patients with ACI admitted to the First People's Hospital of Tianmen in Hubei Province from February 2022 to February 2023 were enrolled and divided into two groups according to different treatment methods. The control group was treated with intravenous thrombolysis (

=48)

and the intervention group was treated with mechanical thrombectomy on the basis of intravenous thrombolysis (

=42). The therapeutic efficacy and adverse reactions of the two groups were compared

and the patients were followed up for 90 days to observe the National Institute of Health Stroke Scale (NIHSS) score before and after treatment and the prognosis of the patients.

Results

Compared with that in the control group

the curative effect of the intervention group was higher (

0.05). The adverse reaction rate of the study group was lower (

0.05). There was no difference in NIHSS score between the two groups before treatment (

0.05)

but it decreased after treatment (

0.05). Compared with that respectively in the control group

the NIHSS score of the study group was lower at 1 d

3 d

30 d and 90 d after treatment

respectively (

0.05). There was no d

ifference in mortality between the two groups (

0.05). Compared with that in the control group

the rate of TICI≥2b was higher and the rate of acute reocclusion was lower in the intervention group (

0.05).

Conclusion

Intravenous thrombolysis combined with mechanical thrombectomy is effective and safe in the treatment of ACI patients

which can reduce the degree of neurological deficit and improve the recanalization rate of occluded vessels.

关键词

Keywords

references

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