Diagnosis value of luteinizing hormone base value and uterine volume in central precocious puberty girls with different BMI

FU Rong; ZHANG Mingying; CHEN Cong; XU Yongsheng; ZHAO Yan; LÜ Ling

doi:10.14188/j.1671-8852.2024.0154

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Diagnosis value of luteinizing hormone base value and uterine volume in central precocious puberty girls with different BMI

更新时间：2026-11-05

- Diagnosis value of luteinizing hormone base value and uterine volume in central precocious puberty girls with different BMI
- Medical Journal of Wuhan University Vol. 46, Issue 9, Pages: 1168-1173(2025)
- 作者机构：
  
  1.天津市儿童医院/天津大学儿童医院/天津市儿童出生缺陷防治重点实验室，内分泌科，天津 300134
  2.天津市儿童医院/天津大学儿童医院/天津市儿童出生缺陷防治重点实验室，呼吸科，天津 300134
- 作者简介：
- 基金信息：
- DOI：10.14188/j.1671-8852.2024.0154
  CLC： R725
- Received：07 March 2024，
  
  Published：26 September 2025
- 稿件说明：
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符榕,张明英,陈枞等.不同体质量指数中枢性性早熟女童黄体生成素基础值和子宫体积检测的诊断价值[J].武汉大学学报（医学版）,2025,46(09):1168-1173.

FU Rong,ZHANG Mingying,CHEN Cong,et al.Diagnosis value of luteinizing hormone base value and uterine volume in central precocious puberty girls with different BMI[J].Medical Journal of Wuhan University,2025,46(09):1168-1173.
符榕,张明英,陈枞等.不同体质量指数中枢性性早熟女童黄体生成素基础值和子宫体积检测的诊断价值[J].武汉大学学报（医学版）,2025,46(09):1168-1173. DOI： 10.14188/j.1671-8852.2024.0154.

FU Rong,ZHANG Mingying,CHEN Cong,et al.Diagnosis value of luteinizing hormone base value and uterine volume in central precocious puberty girls with different BMI[J].Medical Journal of Wuhan University,2025,46(09):1168-1173. DOI： 10.14188/j.1671-8852.2024.0154.

摘要

目的

探究不同体质量指数（BMI）中枢性性早熟女童黄体生成素基础值和子宫体积检测价值。

方法

回顾性分析2019年1月至2023年8月在天津市儿童医院儿科门诊以第二性征提前发育为主诉的女童共488例，其中BMI正常范围女童368例，BMI升高女童120例，对其进行促性腺激素释放试验，并测定相关实验室指标及子宫体积，应用SPSS 21.0软件对数据进行统计分析。

结果

BMI正常范围促性腺激素释放试验阳性组172例，促性腺激素释放试验阴性组196例；BMI升高组，阳性组58例、阴性组62例。两组女童阳性组黄体生成素基础值联合子宫体积均大于阴性组，BMI正常范围、BMI升高黄体生成素基础值诊断中枢性性早熟的界值分别为0.428、0.325 IU•L

-1

，子宫体积的界值分别为2.729、2.424 mL，敏感度分别能达到61.2%、57.4%，特异度分别能达到89.7%、84.2%；不同BMI下应用黄体生成素基础值联合子宫体积诊断中枢性性早熟的诊断曲线下面积高于单用子宫体积诊断，差异具有统计学意义（

0.001），但不同BMI下应用黄体生成素基础值联合子宫体积诊断中枢性性早熟与黄体生成素基础值诊断的曲线下面积比较差异无统计学意义（

0.05）。

结论

联合测定黄体生成素基础值与子宫体积对不同BMI女童中枢性性早熟的临床诊断均具有可靠的价值，能够作为一种简便易行的方式用以中枢性性早熟的诊断。

Abstract

Objective

To investigate the diagnostic value of luteinizing hormone (LH) base value and uterine volume in girls with central precocious puberty with different body mass index (BMI).

Methods

A total of 488 girls who complained of early development of secondary sex characteristics in the pediatric clinic of Tianjin Children's Hospital from January 2019 to August 2023 were retrospectively analyzed

including 368 girls within the normal BMI range and 120 girls with above⁃normal BMI. Gonadotropin release test was performed on them

and relevant laboratory indicators and uterine volume were determined. SPSS 21.0 software was used for statistical analysis of the data.

Results

Among them

172 cases were positive group and 196 cases were negative group. BMI was increased in 58 cases in positive group and 62 cases in negative group. Luteinizing hormone base value combined with uterine volume in the positive group was greater than that in the negative group. The threshold values of normal BMI range and elevated BMI luteinizing hormone base value in the diagnosis of central precocious puberty were 0.428 IU•L

-1

and 0.325 IU•L

-1

respectively

and the threshold values of uterine volume were 2.729 mL and 2.424 mL

respectively. The sensitivity was 61.2% and 57.4%

and the specificity was 89.7% and 84.2%

respectively. The area under the diagnosis curve（

AUC

） of central precocious puberty using luteinizing hormone base value combined with uterine volume under different BMI was higher than that using uterine volume alone

and the results were statistically different (

0.001)

but there was no significant difference in

AUC

between luteinizing hormone base value combined with uterine volume and luteinizing hormone base value in the diagnosis of central precocious puberty (

0.05).

Conclusion

The combination of luteinizing hormone base value and uterine volume of girls with different BMI index has a reliable value for the early diagnosis of central precocious puberty

and could serve as a practical diagnostic tool for central precocious puberty.

关键词

Keywords

references

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